肖毅 - 上海交通大学 - 生命科学技术学院

个人简介

1999-2003 华中科技大学本科（生物技术）2003-2008中国科学院武汉病毒研究所博士（微生物学）2008-2010 中国科学院南海海洋研究所博士后 (天然产物生物合成)2010-2016 美国圣路易斯华盛顿大学博士后(代谢工程和合成生物学)2017-至今上海交通大学特别研究员（生物合成和分子生物技术）

研究领域

主要研究方向是生物合成，分子生物技术和微生物生理生化，最终为工业规模生物合成提供基础。开发基因组编辑技术（例如CRISPR）对细胞宿主进行遗传改造，产生高产的细胞工厂利用细胞内生物传感器（genetically-encoded biosensor）构建分子开关，控制细胞代谢途径和细胞行为，从而提高细胞生物合成的效率研究高产细胞的遗传进化机制和各种对高产表型的生理生化机理。

近期论文

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Gayle J. Bentley, Wen Jiang, Linda P. Guamán, Yi Xiao, Fuzhong Zhang. (2016) Engineering Escherichia coli to produce branched-chain fatty acids in high percentages. Metabolic Engineering 38:148–158 Yi Xiao, Christopher H. Bowen, Di Liu, Fuzhong Zhang. (2016) Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis. Nature Chemical Biology 12, 339–344 Di Liu, Yi Xiao, Bradley S. Evans, and Fuzhong Zhang. (2015) Negative Feedback Regulation of Fatty Acid Production Based on a Malonyl-CoA Sensor–Actuator. ACS Synthetic Biology 4(2):132-140. Wen Jiang, Yanfang Jiang, Gayle J. Bentley, Di Liu, Yi Xiao, Fuzhong Zhang. (2015) Enhanced production of branched-chain fatty acids by replacing β-ketoacyl-(acyl-carrier-protein) synthase III (FabH). Biotechnology and Bioengineering. 112, 1613-1622 Lian He*, Yi Xiao*, Nikodimos Gebreselassie*, Fuzhong Zhang, Maciek R. Antoniewicz, Yinjie J. Tang and Lifeng Peng. (2014) Central metabolic responses to the overproduction of fatty acids in Escherichia coli based on 13C-metabolic flux analysis. Biotechnology and Bioengineering. 111(3):575-85. Yi Xiao, Zhenhua Ruan, Zhiguo Liu, Stephen G. Wu, Arul M. Varman, Yan Liu, Yinjie J. Tang. (2013) Engineering Escherichia coli to convert acetic acid to free fatty acids. Biochemical Engineering Journal 76:60-69 Zhiguo Liu, Zhenhua Ruan, Yi Xiao, Yi Yu, Yinjie J. Tang, Wei Liao, Yan Liu. (2013) Integration of sewage sludge digestion with advanced biofuel synthesis. Bioresource Technology 132:166-170. Arul Varman, Yi Xiao, Himadri Pakrasi, Yinjie J. Tang. (2013) Metabolic engineering of Synechocystis 6803 for isobutanol production. Applied and Environmental Microbiology 79:908-914. Yi Xiao*, Xueyang Feng*, Arul M. Varman*, Lian He, Huifeng Yu, Yinjie J. Tang. (2012) Kinetic modeling and isotopic investigation of isobutanol fermentation by two engineered Escherichia coli strains. Industrial & Engineering Chemistry Research (ACS Publications) 51:15855–15863. Yi Xiao, Ting-Ting Liu, Hui Dai, Jun-Jie Zhang, Hong Liu, Huiru Tang, David J. Leak, and Ning-Yi Zhou. (2012) OnpA, an unusual flavin-dependent monooxygenase containing a cytochrome b5 Domain. Journal of Bacteriology. 194: 1342–1349 Yi Xiao*, Sumei Li*, Siwen Niu, Liang Ma, Guangtao Zhang, Haibo Zhang, Gaiyun Zhang, Jianhua Ju, and Changsheng Zhang. (2011) Characterization of tiacumicin B biosynthetic gene cluster affording diversified tiacumicin analogues and revealing a tailoring dihalogenase. Journal of the American Chemical Society. 133:1092-1105. Arul Varman, Yi Xiao, Effendi Leonard. Yinjie J. Tang. (2011) Statistics-based model for prediction of chemical biosynthesis yield from Saccharomyces cerevisiae. Microbial Cell Factories. 10:45 Siwen Niu, Tao Hu, Sumei Li, Yi Xiao, Liang Ma, Guangtao Zhang, Haibo Zhang, Xiaohong Yang, Jianhua Ju, Changsheng Zhang. (2011) Characterization of a sugar-O-methyltransferase TiaS5 affords new Tiacumicin analogues with improved antibacterial properties and reveals substrate promiscuity. Chembiochem. 12:1740-1748. Liping Gong, Yi Xiao, Qiang Liu, Sumei Li, Changsheng Zhang, Jinsong Liu. (2011). Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallographica Section F. 67:136-139 Yi Xiao, Sumei Li, Liang Ma, Jianhua Ju, and Changsheng Zhang. (2010) Genetic manipulation system for tiacumicin producer Dactylosporangium aurantiacum NRRL 18085. Wei Sheng Wu Xue Bao. 50:1014-1022 (In Chinese) Ying Yin, Yi Xiao, Hai-Zhou Liu, Fuhua Hao, Simon Rayner, Huiru Tang and Ning-Yi Zhou. (2010) Characterization of catabolic meta-nitrophenol nitroreductase from Cupriavidus necator JMP134. Applied Microbiology and Biotechnology. 87: 2077-2085 Qing Wei, Hong Liu, Jun-Jie Zhang, Song-He Wang, Yi Xiao, Ning-Yi Zhou. (2010) Characterization of a para-nitrophenol catabolic cluster in Pseudomonas sp. strain NyZ402 and construction of an engineered strain capable of simultaneously mineralizing both para- and ortho-nitrophenols. Biodegradation. 21: 575-584 Jun-Jie Zhang, Hong Liu, Yi Xiao, Xian-En Zhang, and Ning-Yi Zhou. (2009) Identification and characterization of catabolic para-nitrophenol 4-monooxygenase and para-benzoquinone reductase from Pseudomonas sp. strain WBC-3. Journal of Bacteriology. 191：2703-2710