罗树坤 - 上海交通大学 - 生命科学技术学院

个人简介

中国农业大学生物学学士学位。北京生命科学研究所（NIBS）生化与分子生物学博士，博士期间主要研究DNA损伤修复因子的功能及分子机制，以及非编码RNA与其结合蛋白互作的分子机理。美国哥伦比亚大学博士后，主要研究关键酶调控的分子机制以及RNA修饰参与基因调控的分子机理。现任上海交通大学特别研究员，博士生导师。实验室利用结构生物学（分子晶体学，冷冻电子显微镜cryo-EM）、生物化学、生物物理学、分子生物学、合成生物学以及生物信息学等多学科手段研究重要生物学过程中关键酶的功能、调控及致病的分子机制，进一步寻找相关疾病治疗手段，如与制药公司合作进行小分子药物开发等（参考2018年发表的关于肿瘤免疫小分子抑制剂IDO1抑制剂的文章）。前期研究已经发表在Nature, PNAS, Cell Host & Microbe 及 Immunity等国际顶级期刊上。

研究领域

参与细胞周期及染色体分离的关键酶的功能及调控的分子机制参与RNA末端加工的关键酶的功能及调控的分子机制病原微生物寡聚核苷酸代谢关键酶及参与宿主互作的分子机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Luo S, Xu K, Xiang S, Chen J, Chen C, Guo C, Tong Y, Tong L. (2018). High-resolution structures of human indoleamine 2,3-dioxygenase inhibitor complexes in a new crystal form. Acta Cryst. F74. Luo S, Tong L. (2018). Structural biology of the separase-securin complex with crucial roles in chromosome segregation. Curr Opin Struct Biol. 49: 114-122 (Invited review) Maderbocus R, Fields B, Hamilton K, Luo S, Tran T, Dietrich L, Tong L (2017). Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nature Communications. 8(1):160. Luo S, Tong L. (2017). Molecular mechanism for the regulation of yeast separase by securin. Nature. 542 (7640):255-9. McFarland A, Luo S, Ahmed-Qadri1 F, Zuck M, Thayer1 E, Hybiske K, Tong L, Woodward J (2017). Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-kB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 46 (3):433-445. Zhu Y*, Luo S*, Tong L, Goff S. (2017) Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host & Microbe. 21(2):220-30. Luo S, Xin X, Du LL, Ye K, Wei Y. (2015). Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1. J Biol Chem. 290(34): 21054-66 Huynh TN*, Luo S*, Pensinger D, Sauer JD, Tong L, Woodward JJ. (2015). An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence. Proc Natl Acad Sci USA. 112 (7): E747-56. Luo S, Tong L. (2014). Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain. Proc Natl Acad Sci USA. 111, 13834-13839. Ding YH*, Du YG*, Luo S*, Li YX, Li TM, Yoshina S, Wang X, Klage K, Mitani S, Ye K, Dong MQ. (2013). Characterization of PUD-1 and PUD-2, two proteins up-regulated in a long-lived daf-2 mutant. PLoS One. 14; 8(6): e67158. Yang B, Wu Y, Zhu M, Fan S, Lin J, Zhang K, Li S, Chi H, Chen H, Luo S, Ding Y, Wang L, Hao Z, Li Y, Xiu L, Chen S, Ye K, He S, and Dong M. (2012). An integrated workflow for identification of cross-linked peptides from complex samples. Nat Methods. Luo S, and Ye K. (2012). Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1. FEBS Lett 586, 344-349. Liu J*, Luo S*, Zhao H, Liao J, Li J, Yang C, Xu B, Stern DF, Xu X, and Ye K. (2012). Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res 40, 3898-3912.