个人简介
1992年毕业于武汉大学生物化学专业;1999年于华中农业大学获博士学位;1999年始任教于华中农业大学生命科技学院,历任讲师、副教授、博导。1999-2001年(每年6个月)到英国约翰.印纳斯中心合作,从事链霉菌分化及其调控机理研究;2005-2007年在美国威斯康星大学,从事微生物天然产物的化学生物学研究。2009年始任上海交通大学研究员。
研究领域
放线菌分化和次生代谢调控机理的比较功能基因组研究; 海洋微生物药物挖掘的新策略和新技术; 微生物次生代谢途径解析及途径工程; 抗生素生物合成中的独特酶促反应及其反应机理; 抗生素高产育种的新技术理论体系,及其在重要抗生素菌种高产优化的应用。
近期论文
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Xu H, Chater KF, Deng Z, Tao M*. (2008) A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in Streptomyces. J Bacteriol. 190(14):4971-4978. Wang L, Yu Y, He X, Zhou X, Deng Z, Chater KF, Tao M*. (2007) Role of an FtsK-like protein in genetic stability in Streptomyces coelicolor A3(2). J Bacteriol. 189(6):2310-2318. Li W, Ying X, Guo Y, Yu Z, Zhou X, Deng Z, Kieser H, Chater KF, Tao M*. (2006) Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2). J Bacteriol. 188(24):8368-8375. Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater KF, Tao M*. (2007) A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett. 266(1):20-28. Li W, Zhou H, Tao M*. (2007) Sequences downstream of the start codon and their relations to G + C content and optimal growth temperature in prokaryotic genomes. Antonie van Leeuwenhoek 92(4): 417-427. Wang L, Tao M, Wendt-Pienkowski E, Galm U, Coughlin JM, Shen B*. (2009) Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway. J Biol Chem. 284(13):8256-8264. (共同第一作者) Tao M, Wang L, Wendt-Pienkowski E, George NP, Galm U, Zhang G, Coughlin JM, Shen B*. (2007) The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Mol Biosyst. 3(1):60-74.