李保界 - 上海交通大学 - 生命科学技术学院

个人简介

上海交通大学特聘教授，“长江学者”特聘教授，博导，Bio-X研究院副院长，骨骼干细胞信号转导研究组组长。北京师范大学学士，美国阿尔伯特爱因斯坦医学院博士，哥伦比亚大学博士后。2001-2009任新加坡分子与细胞生物学研究院PI、senior PI。2009年上海“浦江人才”计划获得者，863计划“全基因组关联分析综合平台技术”重点项目课题负责人。目前被聘为BMC Developmental Biology副主编，Current Enzyme Inhibition 等杂志编委。

研究领域

间充质干细胞体内自我更新、分化以及衰老的调控机制；骨骼发育、骨代谢以及骨质疏松症的发病机理；DNA损伤应激发应、衰老以及肿瘤发生。

近期论文

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Wang X, Zeng L, Wang J, Chau JF, Lai KP, Jia D, Poonepalli A, Hande MP, Liu H, He G, He L, Li B*. A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ. 2011;18(1):5-15. Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu H, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B*. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J. 2010;29(17):2994-3006. Rasheed N, Wang X, Niu QT, Yeh J, Li B*. Atm deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoblastogenesis. Human Molecular Genetics. 2006; 15(12): 1938-1948. Wang X, Kua HY, Hu Y, Guo K, Zeng Q, Wu Q, Ng HH, Karsenty G, de Crombrugghe B, Yeh J, Li B*. p53 represses the expression of transcription factor osterix and functions as a negative regulator of osteoblastogenesis and bone formation. J. Cell Biol. 2006; 172:115-125. Li B*, Wang X, Rasheed N, Hu Y, Boast S, Ishii T, Nakayama K, Nakayama KI, Goff SP. Distinct roles for c-Abl and Atm in Prx I induction by modulating expression of protein kinase C. Genes Dev. 2004; 18:1824-1837. Hu Y, Chan E, Wang X, Li B*. Activation of p38MAPK is required for osteoblast differentiation. Endocrinology. 2003; 144(5):2068-2074 Li B, Boast B, de los Santos K, Schieren I, Quiroz M, Teitelbaum SL, Tondravi MM, Goff SP. c-Abl knockout mice are osteoporotic and show defects in osteoblast maturation. Nat Genet. 2000; 24(3): 304-308.