贺新义 - 上海交通大学 - 生命科学技术学院

个人简介

研究兴趣一直聚焦于核苷酸代谢，包括基础代谢中DNA磷硫酰化，羟甲基化，糖羟甲基化等异常修饰形成和识别的分子机理；以及次级代谢中具有良好生物活性的核苷类抗生素的生物合成，如杀稻瘟菌素，米多霉素和精霉素的生物合成的酶学研究。近五年来已发表第一或通讯作者SCI论文14篇，合作论文发表在《自然》杂志上并被评为2011年度中国科学十大进展；获得授权发明专利3项；先后主持4项国家自然科学基金项目。2004、05、09、10和14年度上海交通大学教师年终考核优秀；2005年获中国高等学校十大科技进展；2010年度获得上海交通大学晨星青年学者奖励计划A类。

研究领域

细菌核苷酸修饰及识别的酶学研究核苷类抗生素的生物合成

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Han T, Yamada-Mabuchi M, Zhao G, Li L, Liu G, Ou HY, Deng Z, Zheng Y*, He X*. Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins. Nucleic Acids Res. 2015 Jan; 43(2):1147-59. Zhao G, Wu G, Zhang Y, Liu G, Han T, Deng Z, He X*. Structure of theN-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23specifically recognizes the substrate and controls its entry. Nucleic Acids Res. 2014 Jul; 42(12):8115-24. Liu G, Ou HY, Wang T, Li L, Tan H, Zhou X, Rajakumar K, Deng Z*, He X*. Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. PLoS Genet. 2010 Dec 23; 6(12):e1001253. Liu G, Zhang Z, Zhao G, Deng Z, Wu G*, He X*. Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1; 71(Pt 1):57-60. Feng J, Wu J, Gao J, Xia Z, Deng Z, He X*. Biosynthesis of the β-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941. Appl Environ Microbiol. 2014 Aug; 80(16):5021-7. doi: 10.1128/AEM.01172-14. Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z, He X*. Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway. PLoS One. 2013 Jul18; 8(7):e68545. Li L, Wu J, Deng Z, Zabriskie TM, He X*. Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation. Appl Environ Microbiol. 2013 Apr; 79(7):2349-57. Wu J, Li L, Deng Z, Zabriskie TM, He X*. Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase. Chembiochem. 2012 Jul 23; 13(11):1613-21. Yu Q, Du A, Liu T, Deng Z*, He X*. The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators. Arch Microbiol. 2012 Jun; 194(6):415-26. Ou HY, Kuang SN, He X, Molgora BM, Ewing PJ, Deng Z, Osby M, Chen W, Xu HH*. Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors. Sci Rep. 2015 Mar 2; 5:8643. Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY*. ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Res. 2012 Jan; 40(Database issue):D621-6. Li J, Qu X, He X, Duan L, Wu G, Bi D, Deng Z, Liu W, Ou HY*. ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNAsequences. PLoS One. 2012; 7(9):e45878. Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of streptonigrin biosynthesis reveals a crypticcarboxyl methylation and an unusual oxidative cleavage of a N-C bond. J Am Chem Soc. 2013 Feb 6; 135(5):1739-48. Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi L, He X, Jin SG, IqbalK, Shi YG, Deng Z, Szabó PE, Pfeifer GP, Li J*, Xu GL*. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011 Sep4; 477(7366):606-10.