何亚文 - 上海交通大学 - 生命科学技术学院

个人简介

1992年毕业于华中师范大学生物系；1995年于中国科学院华南植物研究所获植物生理学硕士学位；1995-1997年在中国科学院华南植物研究所工作，任助理研究员；1997年9月赴新加坡国立大学(National University of Singapore, NUS) 留学，1999年9月获植物学硕士学位；1999年12月加入新加坡分子农业生物学院 (Institute of Molecular Agrobiology)，任Assistant Research Officer； 2002年并入新加坡分子与细胞生物研究院 (Institute of Molecular and Cell Biology, IMCB)，任Junior Research Fellow，主要研究野油菜黄单胞菌和水稻白叶枯菌(Xanthomonas)群体感应 (Quorum sensing) 机理；2006年获NUS-IMCB联合培养理学博士学位（研究型）；2007年任分子与细胞生物研究院Research Fellow，主持黄单胞菌群体感应和低氧感应分子机理研究。2010年6月始任上海交通大学生命科学与技术学院研究员，博导，微生物代谢国家重点实验室PI，代谢与发育国际联合实验室PI。

研究领域

病原黄单胞菌群体感应和低氧感应机理及其基因表达调控网络；黄单胞菌与植物之间相互作用的分子机制；植物根际促生菌基因组学和代谢组学及新型绿色农药研发；

近期论文

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Zhou L, Li M, Wang XY, Liu H, Sun S, Chen H, Poplawsky A, He Ya-Wen. Biosynthesis of Coenzyme Q in the Phytopathogen Xanthomonas campestris via a Yeast-Like Pathway. Mol Plant Microbe Interact. 2019，32(2):217-226. Diab AA, Cao XQ, Chen H, Song K, Zhou L, Chen B, He Ya-Wen. BDSF Is the Predominant In-Planta Quorum-Sensing Signal Used During Xanthomonas campestris Infection and Pathogenesis in Chinese Cabbage. Mol Plant Microbe Interact. 2019, 32(2):240-254. Thawai C, He Ya-Wen, Tadtong S. Jishengella zingiberis sp. nov., isolated from root tissue of Zingiber montanum. Int J Syst Evol Microbiol. 2018 Oct; 68(10):3345-3350. Cao, XQ, Zhou L, Chen B, He Ya-Wen. Biosynthesis of Xanthomonas yellow pigment xanthomonadins involves an ATP-dependent 3- HBA:ACP ligase and an unusual type II polyketide synthesis pathway. Molecular Microbiology. 2018, Oct; 110(1):16-32. Qi X, Qu H, Yang D, Zhou L, He Ya-Wen, Yu Y, Qu J, Liu J. Lower respiratory tract microbial composition was diversified in Pseudomonas aeruginosa ventilator-associated pneumonia patients. Respir Res. 2018 Jul 27;19(1):139. Fang Y L, Chen B, Zhou L, He Ya-Wen. The mechanism underlying the regulatory roles of anti-activator QslA on the biosynthesis of phenazine-1-carboxylic acid in Pseudomonas aeruginosa PA1201. Frontiers in Microbiology. 2018, Jul 25; 9:1584. Zhou L, Sun S, Zhang W, He Ya-Wen. Ultra-Performance Liquid Chromatography/Mass Spectrometry for the Detection and Quantification of Diffusible Signal Factor (DSF) Family Quorum-Sensing Signals. Methods Mol Biol. 2018, 1673:97-105. Sun S, Chen B, Jin ZJ, Zhou L, Fang YL, Thawai C, Rampioni G, He Ya-Wen. Characterization of the multiple molecular mechanisms underlying RsaL control of phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacterium Pseudomonas aeruginosa PA1201. Molecular Microbiology. 2017, 104(6):931-947. Zhou L, Wang X, Zhang W, Sun S, He Ya-Wen. Extraction, Purification and Quantification of Diffusible Signal Factor Family Quorum Sensing Signal Molecules in Xanthomonas. Bio-protocol, 2017, 7(6): e2190. Zhou L, Zhang LH, Cámara M, He Ya-Wen. The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover in Xanthomonas. Trends in Microbiology. 2017, 25(4):293-303. Sun S, Zhou L, Jin K, Jiang H, He Ya-Wen. Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Scientific Reports, 2016, 6:30352. Wang Xing-Yu, Zhou Lian, Yang J, Ji Guang-Hai, He Ya-Wen. The RpfB-Dependent Quorum Sensing Signal Turnover System Is Required for Adaptation and Virulence in the Pathogen Xanthomonas. Molecular Plant-Microbe Interactions. 2016, 29(3):220-30. Zhou Lian, Jiang Haixia, Sun Shuang, Yang Dandan, Jin Kaiming, He Ya-Wen. Biotechnological potential of a rhizosphere Pseudomonas aeruginosa strain producing phenazine-1-carboxylic acid and phenazine-1-carboxamide. World Journal of Microbiology and Biotechnology, 2016, 32(3):50. Zhou Lian*, Wang Xing-Yu*, Sun Shuang, Yang Li-Chao, Jiang Bo-Le, He Ya-Wen. Identification and Characterization of Naturally Occurring DSF-Family Quorum Sensing Signal Turnover System in the Phytopathogen Xanthomonas. Environmental Microbiology, 2015, 17(11):4646–4658. Jin Kaiming*, Zhou Lian*, Jiang Haixia, Sun Shuang, Fang Yunling, Liu Jianhua, Zhang Xuehong, He Ya-Wen. Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production. Metabolic Engineering, 2015, 32:30-38. Wang Jia-Yuan*, Zhou Lian*, Chen Bo, Sun Shuang, Zhang Wei, Li Ming, Tang H, Jiang Bo-Le, Tang Ji-Liang, He Ya-Wen. A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity. Scientific Reports, 2015, 5: 18456. Zhou Lian, Yu Yonghong, Chen Xiping, Diab AA, Ruan Lifang, He Jin, Wang Haihong#, He Ya-Wen#. The Multiple DSF-family QS Signals are synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle. Scientific Reports, 2015, 5:13294. Xu Shu, Pan X, Luo J, Wu J, Zhou Z, Liang X, He Ya-Wen, Zhou Mingguo. Effects of phenazine-1-carboxylic acid on the biology of the plant-pathogenic bacterium Xanthomonas oryzae pv. oryzae. Pesticide Biochemistry and Physiology, 2015, 117:39-46.