邓子新 - 上海交通大学 - 生命科学技术学院

个人简介

中国科学院院士（Member，CAS），第三世界科学院院士（Fellow，TWAS），美国微生物科学院院士（Fellow，AAM）。现担任微生物代谢国家重点实验室主任，中国微生物学会理事长, 中国农业生物技术学会副理事长，国际工业微生物遗传学组织专家委员会（GIM-IC）主席。现任美国《ACS Chemical Biology》副主编，《CELL Chemical Biology》, 《Applied & Environmental Microbiology》等数十个国内外刊物编委。 1982年获华中农业大学学士学位，毕业后留校任助教，1987年获英国University of East Anglia博士学位，在英国John Innes 研究中心做博士后一年；1988，1991，1992年先后在华中农业大学始任讲师、副教授、教授；1993年遴选为博导；2000年始任上海交通大学教授。

研究领域

长期从事微生物代谢的分子生物学研究，主攻放线菌遗传学及抗生素生物合成的化学生物学。研究领域涉及DNA复制调控、限制和修饰系统，微生物代谢途径，代谢工程及次级代谢产物的生物化学，非天然抗生素药物创新的基因工程等。 DNA硫修饰生物学微生物次级代谢产物的生物合成

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng Z, Tang Y, Lin S. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc. 2017 Aug 30;139(34):11887-11894. doi: 10.1021/jacs.7b05517. Epub 2017 Aug 15. Gao G, Liu X, Xu M, Wang Y, Zhang F, Xu L, Lv J, Long Q, Kang Q, Ou HY, Wang Y, Rohr J, Deng Z, Jiang M, Lin S, Tao M. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. Cell Chem Biol. 2017 Jul 20;24(7):881-891.e4. doi: 10.1016/j.chembiol.2017.06.008. Epub 2017 Jul 14. Yang Y, Xu G, Liang J, He Y, Xiong L, Li H, Bartlett D, Deng Z, Wang Z, Xiao X. DNA Backbone Sulfur-Modification Expands Microbial Growth Range under Multiple Stresses by its anti-oxidation function. Sci Rep. 2017 Jun 14;7(1):3516. doi: 10.1038/s41598-017-02445-1. Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4135-4140. doi: 10.1073/pnas.1701361114. Epub 2017 Apr 3. Xu Z, Wang Y, Chater KF, Ou HY, Xu HH, Deng Z, Tao M. Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis. Appl Environ Microbiol. 2017 Mar 2;83(6). pii: e02889-16. doi: 10.1128/AEM.02889-16. Print 2017 Mar 15. Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng Z, Tang Y, Lin S. Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J Am Chem Soc. 2017 Aug 30;139(34):11887-11894. doi: 10.1021/jacs.7b05517. Epub 2017 Aug 15. Gao G, Liu X, Xu M, Wang Y, Zhang F, Xu L, Lv J, Long Q, Kang Q, Ou HY, Wang Y, Rohr J, Deng Z, Jiang M, Lin S, Tao M. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. Cell Chem Biol. 2017 Jul 20;24(7):881-891.e4. doi: 10.1016/j.chembiol.2017.06.008. Epub 2017 Jul 14. Yang Y, Xu G, Liang J, He Y, Xiong L, Li H, Bartlett D, Deng Z, Wang Z, Xiao X. DNA Backbone Sulfur-Modification Expands Microbial Growth Range under Multiple Stresses by its anti-oxidation function. Sci Rep. 2017 Jun 14;7(1):3516. doi: 10.1038/s41598-017-02445-1. Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B, Xu M, Lin S, Deng Z, Chooi YH, You D. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4135-4140. doi: 10.1073/pnas.1701361114. Epub 2017 Apr 3. Xu Z, Wang Y, Chater KF, Ou HY, Xu HH, Deng Z, Tao M. Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis. Appl Environ Microbiol. 2017 Mar 2;83(6). pii: e02889-16. doi: 10.1128/AEM.02889-16. Print 2017 Mar 15. Wang Y, Tao Z, Zheng H, Zhang F, Long Q, Deng Z, Tao M. Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy. Metab Eng. 2016 Nov;38:418-426. doi: 10.1016/j.ymben.2016.10.005. Epub 2016 Oct 13. Li N, Wang H, Li L, Cheng H, Liu D, Cheng H, Deng Z. Integrated Approach To Producing High-Purity Trehalose from Maltose by the Yeast Yarrowia lipolytica Displaying Trehalose Synthase (TreS) on the Cell Surface. J Agric Food Chem. 2016 Aug 10;64(31):6179-87. doi: 10.1021/acs.jafc.6b02175. Epub 2016 Jul 29. Xu M, Wang Y, Zhao Z, Gao G, Huang SX, Kang Q, He X, Lin S, Pang X, Deng Z, Tao M. Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp. Appl Environ Microbiol. 2016 Sep 16;82(19):5795-805. doi: 10.1128/AEM.01383-16. Print 2016 Oct 1. Huang T, Li L, Brock N, Deng Z, Lin S. Functional Characterization of PyrG, An Unusual NRPS Module from Pyridomycin Biosynthetic Pathway. Chembiochem. 2016 May 20. doi: 10.1002/cbic.201600156. [Epub ahead of print] Wang H, Li L, Zhang L, An J, Cheng H, Deng Z. Xylitol production from waste xylose mother liquor containing miscellaneous sugars and inhibitors: one-pot biotransformation by Candida tropicalis and recombinant Bacillus subtilis. Microb Cell Fact. 2016 May 16;15:82. doi: 10.1186/s12934-016-0480-0.