当前位置: X-MOL首页全球导师 国内导师 › 周以侹

个人简介

本科及研究生毕业于厦门大学,2005年于新加坡国立大学(Prof Low Boon Chuan Lab)获博士学位,2005-2011年在新加坡国立生物力学卓越研究所及以色列希伯来大学(Prof Emanuel Hanski lab,HHMI member)接受博士后训练,于2011年升任新国大医学院助理研究员。在海外留学工作期间获新加坡千禧年博士研究生奖、新国大校长奖、及千禧年博士后奖。在小G蛋白调控机制方面进行了一系列的研究。鉴定了BCH结构域蛋白家族(BNIP-2蛋白家族),并阐明了该蛋白家族对小G蛋白活性进行调控的分子机制,以及在调控细胞分化、胞内运输以及细胞骨架重排中的重要作用。工作发表在JBC、MBoC、Oncogene以及JCB等国际主流学会刊物。 2012年回国,研究运动系统疾病和干细胞分化的机制,包括肌肉肌腱的衰老与分化再生,以及骨关节炎相关的分子机理。近些年的研究聚焦于生物大分子相分离(phase Separation)的功能与机制研究,细胞核结构(nuclear structure)的重塑在细胞命运决定中的作用,以及代谢重编程(metabolic reprogramming)对再生的调控研究。发现了IGF信号通路的调控新机理,相关成果以通讯作者身份发表在国际高影响因子主流期刊:Cell Discovery(2篇;2022, 2023), Science Advances (2020), Cell Death and Differentiation(2篇; 2020,2021), Aging Cell(2019),Molecular and Cellular Biology(2018),Stem Cells(2018)。

研究领域

肌肉骨骼系统的稳态维持及疾病的机理研究 生物相分离及相变 代谢重塑在干细胞命运决定中的作用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xiu Kui Gao*#, Zu Kang Sheng#, Ye Hong Lu#, Yu Ting Sun, Xi Sheng Rao, Lin Jing Shi, Xiao Xia Cong, Xiao Chen, Hao Bo Wu, Man Huang, Qiang Zheng, Jian-sheng Guo, Liang Jun Jiang*, Li Ling Zheng*, Yi Ting Zhou*. (2023) VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling. Cell Discovery. 9:83 Chen J, Chen XY, Cong XX, Wang S, Xu SB, Sun YT, Zhou YT, Zheng LL, Huang M. CELLULAR SENESCENCE IMPLICATED IN SEPSIS-INDUCED MUSCLE WEAKNESS AND AMELIORATED WITH METFORMIN. Shock. 2023 Apr 1;59(4):646-656. Xiu Kui Gao#, Xi Sheng Rao#, Xiao Xia Cong#, Zu Kang Sheng#, Yu Ting Sun, Shui Bo Xu, Jian Feng Wang, Yong Heng Liang, Lin Rong Lu, Hongwei Ouyang, Huiqing Ge, Jian-sheng Guo, Hang-jun Wu, Qi Ming Sun, Hao-bo Wu, Zhang Bao*, Li Ling Zheng*, Yi Ting Zhou*. (2022) Phase separation of Insulin Receptor Substrate 1 drives the formation of insulin/IGF-1 signalosomes. Cell Discovery. 8:60 Xi Sheng Rao#, Xiao Xia Cong#, Xiu Kui Gao#, Yin Pu Shi, Lin Jing Shi, Jian Feng Wang, Chen-Yao Ni, Ming Jie He, Yingke Xu, Cong Yi, Zhuo-Xian Meng, Jinling Liu, Peng Lin*, Li Ling Zheng*, Yi Ting Zhou*. (2021) AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake. Cell Death and Differentiation. 28(12): 3214-3234. doi: 10.1038/s41418-021-00809-9. Xiao Xia Cong, Xiu Kui Gao, Xi Sheng Rao, Jie Wen, Xiao Ceng Liu, Yin Pu Shi, Min Yi He, Wei Liang Shen, Yue Shen, Hongwei Ouyang, Ping Hu, Boon Chuan Low, Zhuo Xian Meng, Yue Hai Ke, Ming Zhu Zheng, Lin Rong Lu, Yong Heng Liang, Li Ling Zheng*, Yi Ting Zhou*. (2020) Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration. Cell Death and Differentiation 27(8): 2344-2362. doi:10.1038/s41418-020-0508-1 Chichili VPR, Chew TW, Shankar S, Er SY, Chin CF, Jobichen C, Qiurong Pan C, Zhou Y, Yeong FM, Low BC, Sivaraman J. Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2014242118. Yangwu Chen, Weiliang Shen, Chengqi Tang, Jiayun Huang, Chunmei Fan, Zi Yin, Yejun Hu, Weishan Chen, Hongwei Ouyang, Yiting Zhou*, Zhengwei Mao*, Xiao Chen*. (2020) Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification. Science Advances 6(18):eaay9526. Xiaotian Du,Yishan Chen, Qin Zhang, Junxin Lin, Yeke Yu, Zongyou Pan, Heng Sun, Chunhui Yuan, Dongsheng Yu, Haoyu Wu, Xiaoan Zhang, Jun Dai, Shouan Zhu, Yi Ting Zhou*, Hongwei Ouyang* (2020) Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B. Journal of Bone and Mineral Research. 35(5):956-965. DOI: 10.1002/jbmr.3952 Min Yi He, Shui Bo Xu, Zi Hao Qu, Yue Mei Guo, Xiao Ceng Liu, Xiao Xia Cong, Jian Feng Wang, Boon Chuan Low, Li Li, Qiang Wu, Peng Lin, Shi Gui Yan, Zhang Bao, Yi Ting Zhou*, Li Ling Zheng* (2019) Hsp90 interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration. Aging Cell 18(5), e13003 Fan Zhou, Zulin Wu, Mengzhu Zhao, Rakhilya Murtazina, Juan Cai, Ao Zhang, Rui Li, Dan Sun, Wenjing Li, Lei Zhao, Qunli Li, Jing Zhu, Xiaoxia Cong, Yiting Zhou, Zhiping Xie, Valeriya Gyurkovska, Liuju Li, Xiaoshuai Huang, Yanhong Xue, Liangyi Chen, Hui Xu, Haiqian Xu, Yongheng Liang, Nava Segev (2019) Rab5‐dependent autophagosome closure by ESCRT. J Cell Biol 218: 1908–1927 Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng*, and Yi Ting Zhou*(2018)Hsp70 interacts with MAPK-activated protein kinase 2 to regulate p38MAPK stability and myoblast differentiation during skeletal muscle regeneration. Molecular and Cellular Biology 38(24), e00211-18 (Invited Cover Image) Xiao Xia Cong, Xi Sheng Rao, Jun Xin Lin, Xiao Ceng Liu, Guang An Zhang, Xiu Kui Gao, Min Yi He, Wei Liang Shen, Wei Fan, Dominique Pioletti, Li Ling Zheng, Huan Huan Liu, Zi Yin, Boon Chuan Low, Ronen Schweitzer, Hongwei Ouyang, Xiao Chen*, Yi Ting Zhou*. (2018) Activation of AKT-mTOR signaling directs tenogenesis of mesenchymal stem cells. Stem Cells 36(4), 527-539.

推荐链接
down
wechat
bug