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个人简介

浙江大学求是特聘教授,美国心脏协会会士(Fellow of AHA)。长期从事心血管生物学的研究,在干细胞治疗心血管疾病、及衰老对干细胞活性的影响等领域有深入的研究和积极的贡献。在Circulation Research,PNAS,ATVB, Stem Cell等国际著名学术期刊上发表论文八十余篇,以及8部书籍的章节。2011年回国后,已成功申请和参与了国家科技部973项目及重大科学研究计划项目和国家自然科学基金面上项目。 学习和工作经历 1978—1982上海复旦大学生物系 本科 1987—1993 美国南加州大学 博士研究生 1997 —2002 美国南加州大学医学院 助理教授 2003 —2011 美国迈阿密大学医学院 副教授 2011—现在 浙江大学求是特聘教授

研究领域

干细胞治疗心血管疾病;干细胞动员,迁移,归巢和分化机制,及其在心肌修复中的作用;衰老对干细胞生物活性及其促血管新生能力的影响;干细胞分泌的外泌体exosome对心血管病的影响, 血管钙化的防治。 

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Yang F, RR Wu, Z Jiang, J Chen, JL Nan, SA Su, N Zhang, C Wang, J Zhao, C Ni, YC Wang, WX Hu, ZR Zeng, KY Zhu, XB Liu, XY Hu, W Zhu, H Yu, and JY Huang, JA Wang. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death and Disease. 2018 March 30, In press. 2. Shen J, N Zhang, YN Lin, PP Xiang, XB Liu, PF Shan, XY Hu, W Zhu, YL Tang, KA Webster, RZ Cai, A Schally, JA Wang, H Yu* Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists. Circulation Research, April 4, 2018. https://doi.org/10.1161/CIRCRESAHA.117.312418 3. Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT, Hu X, Wang J. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circulation Research. 122:958-969 Jan 17, 2018; 4. Ruan Xf, Li YJ, Ju CW, Shen Y, Lei W, Chen C, Li Y, Yu H, Liu YT, Kim IM, Wang XL, Weintraub NL, Tang YL. Exosomes from Suxiao Jiuxin Pill-treated cardiac mesenchymal stem cells down-regulate H3k27 demethylase UTX expression in cardiomyocytes. Acta Pharmacologica Sinica. 2018, Apr;39(4):579-586 5. Ruan Xf, Ju CW, Shen Y, Liu YT, Kim IM, Yu H, Weintraub NL, Wang XL, Tang YL. Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro. Acta Pharmacologica Sinica. 2018, Apr;39(4):569-578 6. JY Zhu, K Lu, N Zhang, Y Zhao, QC Ma, J Shen, YN Lin, PP Xiang, YL Tang, XY Hu, JH Chen , W Zhu, KA Webster, JA Wang, H Yu*. Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artificial Cells, Nanomedicine and Biotechnology. 2017. Nov 16:1-12. 7. Zhou Y, Chen PP, Liu QN, Wang YC, Zhang L, Wu RR, Chen JH, Yu H, Zhu W, Hu XY, and Wang JA. Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury. Stem Cells International, Vol. 2017, November Article ID 1096980, 12 pages, 2017. doi:10.1155/2017/1096980. 8. Hu DX, Nan JL, Sun Y, Zhu D, Xiao CC, Wang YP, Zhu LL, Wu Y, Zhao J, Wu RR, Chen JH, Yu H, Hu XY, Zhu W, Wang JA. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A., 2017, Nov 7;114(45):11908-11913. 9. Jin-Liang Nan; Wei Zhu; Rahman MS; Mingfei Liu; Sheng'an Su; Na Zhang; Dan Li; Xinyang Hu; Hong Yu; Mahesh P Gupta; Jian'an Wang. Molecular Regulation of Mitochondrial Dynamics in Cardiac Disease. BBA - Molecular Cell Research. 2017, Jul; 1864(7):1260-1273. 10. Hu DX, Z Zeng, W Zhu, N Zhang, H Yu, H Chen, K Wang, YC Wang, LM Wang, J Zhao, L Zhang, RR Wu, XY Hu, XB Liu, JA Wang. SRT1720 Promotes Survival of Aged Human Mesenchymal Stem Cells via FAIM: a Pharmacological Strategy to Improve Stem Cell Based Therapy for Rat Myocardial Infarction。Cell Death and Disease. 2017 Apr 6;8(4):e2731. 11. Yu H, K Lu, JY Zhu, JA Wang*. Stem Cell Therapy for Ischemic Heart Disease. British Medical Bulletin. 2017 Feb 06 , 121 (1): 135-154. DOI: 10.1093/bmb/ldw059 12. Wang C, H Chen, W Zhu, MF Liu, YC Xu, LL Zhu, F Yang, L Zhang, XB Liu, Z Zhong, J Zhao, J Jiang, M Xiang, Yu H, X Hu, H Lu, and JA Wang. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells。Arteriosclero Thromb Vasc Biol. 2017 Jan; 37(1):53-65. 13. Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016 Nov;21(6):723-736. 14. Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2016 Aug 29. pii: sctm.2015-0386. 15. Ying-Mei Feng, Catherine Verfaillie, and Hong Yu. Vascular Diseases and Metabolic Disorders, Editorial. Stem Cells Int. 2016 Oct 20, Volume 2016, Article ID 5810358. 16. Adi N, Adi J, Lassance-Soares RM, Kurlansky P, Yu H, Webster KA. High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice association with diet/genetics-regulated micro-RNAs. J Diabet Metabol. 2016 Jun 16, 7:676; DOI: 10.4172/2155-6156.1000676 (IF 4.101) 17. Boden J, Lassance-Soares RM, Wang H, Wei Y, Spiga MG, Adi J, Layman H, Yu H, Vazquez-Padron RI, Andreopoulos F, Webster KA. Vascular Regeneration in Ischemic Hindlimb by Adeno-Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor. J Am Heart Assoc. 2016 May 26;5(6). pii: e001815. doi: 10.1161/JAHA.115.001815. 18. Ma Q, X Xia, Q Tao, K Lu, J Shen, Q Xu, X Hu, Y Tang, NL Block, KA Webster, AV Schally, Wang J, H Yu*. Profound actions of an agonist of growth hormone releasing hormone on angiogenic therapy by mesenchymal stem cells. Arteriosclero Thromb Vasc Biol. 2016;36:663-672.

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