徐荣臻 - 浙江大学

个人简介

徐荣臻医学博士，浙江大学医学院，研究员，博士研究生导师。1991 浙江医科大学获得医学硕士学位，2001 浙江大学医学院获得医学博士学位，2001 美国约翰霍普金斯大学访问学者，2009-2010 美国City of Hope 国家医学中心访问学者。中华医学会浙江分会血液学会委员,国际输血和血液学杂志编委.

研究领域

主要从事人恶性肿瘤发病机制和新型分子靶向性抗肿瘤药物的研究，近年来在人白血病细胞和肝癌细胞恶性增殖分子机制、新型分子靶向性抗白血病药物的研究领域取得了系列成果： (1)发现了蛋白酪氨酸磷酸酶Shp2过度活化和异常分布参与成人白血病细胞恶性增殖病理过程，Shp2是一种新的白血病相关细胞原癌基因(Blood 2005，第一和共同通讯作者；Cell Research 2007，通讯作者）。 (2)发现了小分子化合物小檗胺能靶向性清除慢性髓系白血病干细胞，并证实通过抑制白血病干细胞存活必需的CaMK2G, bcr/abl融合基因转录和核转录因子NF-κBp65进核独特机制诱导白血病干细胞死亡（Blood, 2012）。设计和合成了系列新型小檗胺衍生物，已获得国家新药发明专利（专利号ZL200810060382.1）。 (3) 发现了APOBEC3脱氨酶是肝癌细胞内诱发乙肝病毒HBX突变体产生的主要因子

近期论文

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1.Gu Y, Chen T, Meng Z, Gan Y, Xu X, Lou G, Li H, Gan X, Zhou H, Tang J, Xu G, Huang L, Zhang X, Fang Y, Wang K, Zheng S, Huang W, Xu R（徐荣臻,通讯作者）. CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine. Blood. 2012 Oct 16. [Epub ahead of print]. 2.Xu XH, Gan YC, Xu GB, Chen T, Zhou H, Tang JF, Gu Y, Xu F, Xie YY, Zhao XY, Xu RZ.Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis.J Zhejiang Univ Sci B. 2012;13:867-74（徐荣臻,通讯作者）. 3.Meng Z, Wang X, Gan Y, Zhang Y, Zhou H, Ness CV, Wu J, Lou G, Yu H, He C, Xu R（徐荣臻,共同通讯作者）, Huang W. Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol. 2012 ;57:1004-12. 4.Meng Z, Fu X, Chen X, Zeng S, Tian Y, Jove R, Xu R（徐荣臻）, Huang W. miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice.Hepatology. 2010; 52:2148-57. 5.Kong M, Fan J, Dong A, Cheng H, Xu R（徐荣臻）. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010; 42:827-33. 6.Liang Q, Ding J, Xu R（徐荣臻）, Xu Z, Zheng S. The novel human endogenous retrovirus related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers. Int J Cancer. 2010; 127:1833-43. 7.Gu Y, Ting Z, Qiu X, Zhang X, Gan X, Fang Y, Xu X, Xu R(徐荣臻，通讯作者). Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors. Toxicology. 2010; 268: 19-24. 8.Liang Y, Xu RZ（徐荣臻）, Zhang L, Zhao XY. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009; 30:1659-65. 9.Xie J, Ma T, Gu Y, Zhang X, Qiu X, Zhang L, Xu R（徐荣臻，共同通讯作者）, Yu Y. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009; 44: 3293-8. 10.Chen G, He Z, Wang T, Xu R（徐荣臻）, Yu XF. A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G. J Virol. 2009; 83:8674-82. 11.Liang Q, Ding J, Xu R（徐荣臻）, Xu Z, Zheng S. Identification of a novel human endogenous retrovirus and promoter activity of its 5' U3. Biochem Biophys Res Commun. 2009; 382:468-72. 12.Wang GY, Lv QH, Dong Q, Xu RZ（徐荣臻）, Dong QH. Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.J Asian Nat Prod Res. 2009; 11:219-28. 13.Wei Zhang, Xuzhao Zhang, C.Tian, Tao Wang, Phuong Thi Nguyen Sarkis, Yongmin Fang, Shu Zheng, and Xiao-Fang Yu, Rongzhen Xu（徐荣臻，通讯作者）. Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses HBV expression. Cellular Microbiology. Cell Microbiol. 2008; 10:112-21. 14.Rongzhen Xu（徐荣臻）, Xuzhao Zhang, Wei Zhang, Yongmin Fang, Shu Zheng, and Xiao-Fang Yu. Association of human APOBEC3 cytidine deamineases with the generation of hepatitis B x antigen mutants and hepatocellular carcinoma.Hepatology, 2007; 46：1810-1820(影响因子 10.45). 15.Xu R（徐荣臻, 通讯作者）. Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia. Cell Res. 2007; 17:295-297. 16.Zhao XY, He ZW, Wu D, Xu RZ（徐荣臻，通讯作者）. Berbamine selectively induces apoptosis of human acute promyelocytic leukemia cells via survivin-mediated pathway. Chin Med J (Engl). 2007; 120: 802-6. 17.Xu R(徐荣臻，通讯作者), Dong Q, Yu Y, Zhao X, Gan X, Wu D, Lu Q, Xu X, Yu XF. Berbamine: a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity. Leuk Res. 2006; 30:17-23. 18.Xu R（徐荣臻）, Yu Y, Zheng S, Zhao X, Dong Q, He Z, Liang Y, Lu Q, Fang Y, Gan X, Xu X, Zhang S, Dong Q, Zhang X, Feng GS.Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.Blood. 2005;106:3142-9.