吴育连 - 浙江大学

个人简介

1983年获医学学士学位，1989获肝胆胰外科硕士学位，1994年受中德文化交流基金资助，赴德国吕贝克医科大学外科研究所进修1年，1998年6月获肝胆胰外科博士学位；2000, 2003和2004年曾3次先后受国家留学基金及中加国际合作项目资助,作为访问学者短期（3-6个月）赴Montreal大学参加2000年美国糖尿病基金会（JDF）和2002加拿大高校科研基金（CHIR）有关胰岛移植研究的合作项目。1996年至今共负责完成或承担国家自然基金7项;国家863项目一项，省部级重大项目10余项，总经费达500余万。与加拿大蒙特利尔大学移植免疫研究所联合申请国际合作专利1项，国内有关功能胰岛示踪及胰岛干细胞分化专利2项。作为项目负责人获省部级二等奖２项；参加国家科技进步奖1项（4/10）。2003年获浙江省跨世纪151人才工程的重点资助；2004年卫生部突出贡献中青年专家，国家自然基金二审专家。

研究领域

1，胰腺癌早期诊断分子标记物筛选 2，胰腺化疗耐药及增敏分子机制及调控 3，功能胰岛及胰腺癌细胞分子影像示踪技术 4，胰腺癌及肝癌的RFA及分子靶向治疗综合治疗 5，胰岛干细胞定向分化的研究 6，维护胰岛移植物功能的研究

近期论文

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1. Huang H, Dong X, Kang MX, Xu B, Chen Y, Zhang B, Chen J, Xie QP, Wu YL*; Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles. Am J Gastroenterol. 2010 Jul;105(7):1661-9. IF=6.882 2. Guo Q, Chen Y, Zhang B, Kang M, Xie Q, Wu YL*： Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition. Biochem Pharmacol. 2009 Jun 1;77(11):1674-83. IF=4.889 3. Huang H, Xie Q, Kang M, Zhang B, Zhang H, Chen J, Zhai C, Yang D, Jiang B, Wu YL*; Labeling transplanted mice islet with polyvinylpyrrolidone coated superparamagnetic iron oxide nanoparticles for in vivo detection by magnetic resonance imaging. Nanotechnology. 2009 Sep 9;20(36):365101. IF=3.644 4. Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL*：Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation. 2009 Jun; 77(5):483-91.IF=3.069 5. Dong X, Zhang B, Kang MX, Chen Y, Guo QQ,; Analysis of pancreatic fistula according to the International Study Group Wu YL* on Pancreatic Fistula classification scheme for 294 patients who underwent pancreaticoduodenectomy in a single center. Pancreas. 2011 Mar;40(2):222-8. IF=2.733 6. Guo Q, Zhang B, Dong X, Xie Q, Guo E, Huang H， Wu YL*, . Elevated levels of plasma fibrinogen in patients with pancreatic cancer: possible role of a distant metastasis predictor. Pancreas. 2009 Apr;38(3):e75-9.IF=2.733 7. Guo Q, Kang M, Zhang B, Chen Y, Dong X, Wu YL* ；Eevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes. J Cancer Res Clin Oncol. 2010 Nov;136(11): 1627-31. IF=2.485 8. Dong X, Zhan YC, Jiang RY, Xie QP, Peng JP, Wang J, Gao SL, Wu YL*：The Potential Effect of Proteasome Inhibitor PS-341 on Severe Acute Pancreatitis Detected by Positron Emission Tomography in ICR Mice. J Surg Res. 2010 Aug; 162(2):193-202. IF=2.239 9. Huang H, Dong X, Gao SL, Wu YL* ：Conservative resection for benign tumors of the proximal pancreas. World J Gastroenterol. 2009 Aug 28; 15(32):4044-8. IF=2.24 10. Yan H, Lu D, Xu L, Xie Q, Dong X, Wu YL*. Increased expression level of Olfactomedin4 in peripheral blood mononuclear cells of pancreatic adenocarcinoma patients. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1354-9. 11. Tang Z, Fang H, Kang M, Zhang B, Dong X, Chen X, Xu J, Chen J, Wu YL*. Percutaneous radiofrequency ablation for liver tumors: Is it safer and more effective in low-risk areas than in high-risk areas? Hepatol Res. 2011 Jul;41(7):635-40. IF=1.857 12. Jiang W, Zhang B, Fu YB, Wang JW, Gao SL, Zhang SZ, Wu YL*; Gastric duplication cyst lined by pseudostratified columnar ciliated epithelium: a case report and literature review. J Zhejiang Univ Sci B. 2011 Jan;12(1):28-31 IF=1.027 13. Zhang B, Xie QP, Gao SL, Wu YL*, ：Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern. J Zhejiang Univ Sci B. 2010 Jan;11(1):22-6 IF=1.027 14. Sun CD, Zhang B, Zhang JK, Xu CJ, Wu YL,, Li X, Chen KS；Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice. J Med Food. 2011 Dec 19. [Epub ahead of print] IF 1.461