王晓东 - 浙江大学 - 脑科学与脑医学学院

个人简介

科研项目 2019年，北京市科学技术奖（二等奖，第三完成人） 2012年，国际脑研究组织IBRO Return Home Fellowship 2011年，德国内分泌学会Ernst and Berta Scharrer奖

研究领域

跨模态感觉整合与应激相关精神疾病

近期论文

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Wang C#, Liu H#, Li K#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ, Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. Nature Communications 11, 6045. Liu YJ*,#, Zhang T#, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD*, Ho MS*, Duan S (2021). The noncanonical role of the protease cathepsin D as a cofilin phosphatase. Cell Research, in press, doi: 10.1038/s41422-020-00454-w. Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances 6, eaba5783. Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY, Wang XD* (2018). Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits. Neuropharmacology 135, 474-486. Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV, Wang XD* (2018). Chronic stress reduces nectin-1 mRNA levels and disrupts dendritic spine plasticity in the adult mouse perirhinal cortex. Frontiers in Cellular Neuroscience 12, 67. Li K#, Shen S#, Ji YT, Li XY, Zhang LS, Wang XD* (2018). Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF-TrkB signaling. Neuroscience Bulletin 34, 303-311. Li JT#, Xie XM#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV, Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Reports 21, 891-900. Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV, Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory. Translational Psychiatry 7, e1228. Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV, Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40, 1203-1215. Liao XM, Yang XD, Jia J, Li JT, Xie XM, Su YA, Schmidt MV, Si TM*, Wang XD* (2014). Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus. Hippocampus 25, 528-540. Wang XD, Su YA, Avrabos C, Wagner KV, Liebl C, Wolf M, Scharf SH, Hartmann J, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV* (2013). Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience 16, 706-713. Wang XD*, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV (2011). Forebrain CRF1 modulates early life stress-programmed cognitive deficits. The Journal of Neuroscience 31, 13625-13634. Wang XD*, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV (2011). Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiology of Disease 42, 300-310.