王青青 - 浙江大学

个人简介

学习和工作经历： 1989.9-1994.6 浙江医科大学本科（临床医学） 1994.9-2000.6 免试攻读浙江大学肿瘤所研究生，获肿瘤学博士学位 1999.12-2002.3 第二军医大学免疫学研究所合作研究 2000.8- 浙江大学免疫学研究所工作 2005.12-2007.1 Duke University Research Associate 2008.12-2009.3 Yale University Visiting Professor

研究领域

1. 恶性肿瘤免疫逃逸和转移的机制； 2. 恶性肿瘤的免疫基因治疗； 3. 免疫细胞分化发育和功能的表观调控机制。

近期论文

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1. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, Wang Q, Li D, Wang J, Zheng P, Liu Y, Cao X. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell. 2013;152(3):467-78 2. Lai L, Song Y, Liu Y, Chen Q, Han Q, Chen W, Pan T, Zhang Y, Cao X, Wang Q*. MicroRNA-92a negatively regulates TLR-triggered inflammatory response in macrophages by targeting MKK4. J Biol Chem. 2013;288(11):7956-67 3. Liu Y, Lai L, Chen Q, Song Y, Xu S, Ma F, Wang X, Wang J, Yu H, Cao X, Wang Q*. MicroRNA-494 is required for the accumulation and function of tumor-expanded myeloid-derived suppressor cells via targeting PTEN. J Immunol. 2012;188(11):5500-10 4. Chen Q, Wang H, Liu Y, Song Y, Lai L, Han Q, Cao X, Wang Q*. Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3. PLoS One. 2012;7(8):e42971 5. Guo Q, Lv Z, Fu Q, Jiang C, Liu Y, Lai L, Chen Q, Shen J, Wang Q. IFN-γ producing T cells contribute to the increase of myeloid derived suppressor cells in tumor-bearing mice after cyclophosphamide treatment. Int Immunopharmacol. 2012;12(2): 425-432 6. Lai LH, Fu Q, Liu Y, Jiang K, Guo Q, Chen Q, Yan B, Wang Q*, Shen J. In vitro and in vivo effects of Piperine on tumor growth and metastasis in a 4T1 murine breast cancer model. Acta Pharmacol Sin. 2012; 33(4):523-30 7. Jiang K, He B, Lai L, Chen Q, Liu Y, Wang Q*. Cyclosporine A inhibits breast cancer cell growth by down-regulating the expression of pyruvate subtype M2. Int J Mol Med. 2012; 30(2):302-8 8. Liu Y, Chen Q, Song Y, Lai L, Wang J, Yu H, Cao X, Wang Q*. MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett. 2011;585(12):1963-8 9. Hu G, Liu Y, Li H, Zhao D, Yang L, Shen J, Hong X, Cao X, Wang Q*. Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect. Cell Mol Immunol. 2010;7(4):296-305 10. Hong XJ, Liu Y, Hu G, Zhao D, Shen J, Shen FP, Cao X, Wang Q*. EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma. Cancer Sci. 2009; 100(5): 961-9 11. Wang QQ, Li H, Oliver T, Glogauer M, Guo J, He YW. Integrin β1 regulates phagosome maturation in macrophages through Rac expression. J Immunol. 2008;180 (4): 2419-2428