沈华浩 - 浙江大学

个人简介

浙江大学求是特聘教授、教育部“长江学者”特聘教授；浙江大学医学院副院长，浙江大学呼吸疾病研究所所长，浙江大学医学院附属二院呼吸和危重医学科主任。国家食品药品监督管理局药物临床试验机构（呼吸专业）负责人、卫生部呼吸专科医师培训基地主任、国家临床重点专科（呼吸内科）学科带头人。

研究领域

哮喘和慢性阻塞性肺疾病发病机制及防治研究、肺部感染、肺癌发生和转移机制、呼吸和抗感染药物临床药理研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhengqijang Bao,Baoping Tian, Xiaohui Wang, Ye Liang, Zhihua Chen, Wen Li, Huahao Shen, *Songmin Ying. Oleandrin Induces DNA Damage Responses in Cancer Cells by Suppressing the expression of Rad51. Oncotarget. 2016, online. 2. Fang Liu, Nan-Xia Xuan, Songmin Ying, Wen LI, Zhi-Hua Chen and *Huahao Shen. Herbal medicines for asthmatic inflammation: from basic researches to clinical applications. Mediators of Inflammation. 2016, online. 3. Yue Hu, Jian Lou, Yuan-Yuan Mao, Tian-Wen Lai, Li-Yao Liu, Chen Zhu, Chao Zhang, Juan Liu, Yu-Yan Li, Fan Zhang, Wen Li, Song-Min Ying, *Zhi-Hua Chen, *Hua-Hao Shen.Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy. Accepted. 4. Xia LX, Hua W, Jin Y, Tian BP, Qiu ZW, Zhang C, Che LQ, Zhou HB, Wu YF, Huang HQ, Lan F, Ke YH, Lee JJ, Li W, Ying SM, Chen ZH, *Shen HH.Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2. Cell Death Dis. 2016 Apr 7;7:e2175. doi: 10.1038/cddis.2016.74. 5. Zhou JS, Zhao Y, Zhou HB, Wang Y, Wu YF, Li ZY, Xuan NX, Zhang C, Hua W, Ying SM, Li W, Shen HH, *Chen ZH. Autophagy Plays an Essential Role in Cigarette Smoke-Induced Expression of MUC5AC in Airway Epithelium. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1:ajplung.00418.2015. doi: 10.1152/ajplung.00418.2015. [Epub ahead of print] 6. Che L, Jin Y, Zhang C, Lai T, Zhou H, Xia L, Tian B, Zhao Y, Liu J, Wu Y, Wu Y, Du J, Li W, Ying S, Chen Z,*Huahao Shen. Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade. Sci Rep. 2016 Jan 7;6:18680. doi: 10.1038/srep18680. 7. Zhang C, Zhang LH, Wu YF, Lai TW, Wang HS, Xiao H, Che LQ, Ying SM, Li W, Chen ZH, *Huahao Shen. Suhuang antitussive capsule attenuates airway hyperresponsiveness, inflammation, and remodeling in a murine model of chronic asthma. Sci Rep. 2016 Feb 10;6:21515. doi: 10.1038/srep21515. 8. Chao Cao, Tianwen Lai, A Miao, Hongbin Zhou, Zaichun Deng, Songmin Ying, Zhihua Chen, Wen Li, *Huahao Shen. Smoking-promoted oxidative DNA damage response is highly correlated to lung carcinogenesis. Oncotarget 2016 Mar 1. doi: 10.18632/oncotarget.7810. [Epub ahead of print] 9. Chao Cao, Wen Li, *Huahao Shen. Reduced-Nicotine Cigarettes: A Double-edged Sword (To the Editor). N Engl J Med. 2016,374(4):394-395 10. Chao Cao , Yinfang Wu , Zhiwei Xu , Dan Lv , Chao Zhang , Tianwen Lai , Wen Li, *Huahao Shen. The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research. Sci Rep. 2015 Nov 10;5:16461. doi: 10.1038/srep16461. 11. Zhi-Hua Chen , Yin-Fang Wu, Ping-Li Wang, Yan-Ping Wu, Zhou-Yang Li, Yun Zhao, Jie-Sen Zhou, Chen Zhu, Chao Cao, Yuan-Yuan Mao, Feng Xu, Bei-Bei Wang, Stephania A Cormier, Song-Min Ying, *Wen Li, *Hua-Hao Shen. Autophagy Is Essential for Ultrafine Particle-Induced Inflammation and Mucus Hyperproduction in Airway Epithelium. Autophagy. 2016 Feb;12(2):297-311. doi: 10.1080/15548627.2015.1124224. 12. Sheroy Minocherhomji, Songmin Ying, Victoria A. Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W. Mankouri, *Huahao Shen, *Ying Liu, and *Ian D. Hickson*. Replication Stress Activates DNA Repair Synthesis in Mitosis. Nature. 2015. DOI:10.1038/Nature16139 . 13. Zhengqiang Bao, Chao Cao, Xinwei Geng, Baoping Tian, Yanping Wu, Chao Zhang, Zhihua Chen, Wen Li, *Huahao Shen, *Songmin Ying. Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: A systematic review and meta-analysis. Oncotarget. 2016 Feb 16;7(7):7629-39. doi: 10.18632/oncotarget.5367. 14. Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, *Ying S.Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget. 2015 Nov 10;6(35):37638-46. doi: 10.18632/oncotarget.5497. 15. Hua W, Liu H, Xia LX, Tian BP, Huang HQ, Chen ZY, Ju ZY, Li W, Chen ZH, *Shen HH. Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice. Respirology. 2015 Oct;20(7):1055-65. doi: 10.1111/resp.12554. Epub 2015 Jun 4. 16. Daxin Chen, Min Xia, Claudia Hayford, Vikki Semik, El-Li Tham, Stuart Hurst, Ying Chen, Henry H. Tam, Jun Pan, Yucheng Wang, Xiaojin Tan, Huiyao Lan, Huahao Shen, Vijay V. Kakkar, Qingbo Xu, John H. McVey and *Anthony Dorling. Expression of Human Tissue Factor Pathway Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerosis in ApoE-/- Mice. Circulation. 2015; February 12 2015 as doi:10.1161 / CIRCULAT ION AHA.114.013423v 17. Tianwen Lai, Shaobin Wang, Zhiwei Xu, Chao Zhang, Yun Zhao, Yue Hu, Chao Cao, Songmin Ying, Zhihua Chen, Wen Li, Bin Wu, *Huahao Shen. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Scientific Reports. 2015 Aug 14;5:9548. doi: 10.1038/srep09548.