钱文斌 - 浙江大学

个人简介

1981年绍兴地区卫生学校医士专业毕业，1992获浙江医科大学内科（血液学）硕士学位，2000年获浙江大学血液学博士学位。2002年在德国基尔大学血液病理所做高级访问学者。1992年至今在浙江大学医学院附属第一医院从事血液病临床和实验研究。

研究领域

（1）血液肿瘤基础及临床研究；（2）基因治疗、病毒治疗；（3）细胞自噬、细胞凋亡

近期论文

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(1) Yang C, Tong Y, Ni W, Liu J, Xu W, Li L, Liu X, Meng H, Qian W*. Inhibition of autophagy induced by overexpression of MDA/Interleukin-24 using a PI3K inhibitor results in significant enhanced antileukmia activity in vivo. Cancer Gene Ther. 2010; 17:109-119. (2) Xu WL, Jin J, Qian WB*. Homoharringtonine in combination with cytarabine and aclarubicin as induction therapy improves remission and survival of patients with higher risk myelodysplastic syndromes. Chin Med J (Engl). 2010;123:108-110. (3) Wang HP, Xu H, Chen ZM, Tong XM, Qian WB, Jin J. t(X;17) as the sole karyotypic anomaly in a case of M(3r) subtype of acute promyelocytic leukemia without RARα rearrangement. Leuk Res. 2010;34:e55-57. (4)Jin J, Liu H, Yang C, Li G, Liu X, Qian Q, Qian W*. Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. Mol Cancer Ther. 2009; 8:1387-1397. (5) Wang G, Li G, Liu H, Yang C, Yang X, Jin J, Liu X, Qian Q, Qian W*. E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for B-lymphocytic malignancies. J Gene Med. 2009;11:477-485. (6) Li GC, Li N, Zhang YH, Li X, Wang YG, Liu XY, Qian W*, Liu XC. Mannose-exposing acute myeloid leukemia cells detected by the sCAR-PPA fusion protein. Int J Hematol. 2009; 89:611-617. (7) Meng HT, Li L, Liu H, Wang Y, Li GC, Qian WB*. Homoharringtonine acts synergistically with SG235-TRAIL, a conditionally replicating adenovirus, in the treatment of leukemia. Acta Pharmacol Sin. 2009; 11:1529-1536. (8) Cheng Y, Wang Y, Wang H, Chen Z, Lou J, Xu H, Wang H, Qian W, Meng H, Lin M, Jin J. Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China. Leukemia 2009, 23(10):1801-1806. (9) Qian W*, Liu J, Tong Y, Yan S, Yang C, Yang M, Liu X. Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis. Leukemia. 2008; 22: 361-369. (10) Meng H, Yang C, Jin J, Zhou Y, Qian W*. Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Leuk Lymphoma. 2008;49:1954-1962. (11) Tong H, Ren Y, Liu H, Xiao F, Mai W, Meng H, Qian W, Huang J, Mao L, Tong Y, Wang L, Qian J, Jin J. Clinical characteristics of T-cell lymphoma associated with hemophagocytic syndrome: Comparison of T-cell lymphoma with and without hemophagocytic syndrome. Leuk Lymphoma. 2008;49:81-87. (12) Tong XM, Yao HP, Qian WB, Zhu LF, Fu ZH, Huang ZL, Jin J. The biological characteristics of dendritic cells derived in vitro from myelogeneous leukemia cells and healthy donor cells. Int J Lab Hematol. 2008;30:372-381. (13) Jiao Y, Zhang W, Liu J, Ni W, Xu W, Jin J, Qian W*. Telomere Attrition and Chromosome Instability via Downregulation of TRF2 Contributes to Arsenic Trioxide-Induced Apoptosis of Human T-Cell Leukemia Cell Line Molt-4 Cells. Cancer Biol Ther. 2007;6:1186-1192. (14) Qian W*, Liu J, Jin J, Ni W, Xu W. Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res. 2007;31:329-339. (15) Meng H, Yang C, Ni W, Ding W, Yang X, Qian W*. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur J Haematol. 2007;79:486-493. (16) Yang X, Yang C, Shao K, Ye X, Meng H, Zhou Y, Qian W*. Refractory multiple myeloma treated with homoharringtonine: report of two cases. Ann Hematol. 2007;86:919-921. (17) Zhang Y, Gu J, Zhao L, He L, Qian W, Wang J, Wang Y, Qian Q, Qian C, Wu J, Liu XY. Complete Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Virotherapy. Cancer Res 2006;66: 4291-4298. (18) Jin J, Jiang DZ, Mai WY, Meng HT, Qian WB, Tong HY, Huang J, Mao LP, Tong Y, Wang L, Chen ZM, Xu WL. Homoharringtonine in combination with cytarabine and aclarubicin resulted in high complete remission rate after the first induction therapy in patients with de novo acute myeloid leukemia. Leukemia. 2006;20:1361-1367. (19) Lou YJ, Qian WB, Jin J. Homoharringtonine induces apoptosis and growth arrest in human myeloma cells. Leuk Lymphoma. 2007;48:1400-1406.