那仁满都拉 - 浙江大学

研究领域

三氧化二砷（As2O3）及其活性代谢产物（如一甲基和二甲基亚砷酸，以及含硫砷化合物）对线粒体的损伤及呼吸链复合体的影响，以及对急性早幼粒细胞性白血病（APL）分化和PML-RARα融合蛋白降解机制；适配体（Aptamer）靶向治疗肿瘤疾病及药物开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Wang, Q.Q., Zhou, X.Y., Zhang, Y.F. Bu, N., Zhou, J., Cao, F.L., Naranmandura, H* (2015) Methylated Arsenic Metabolites Bind to PML Protein but Do not Induce Cellular Differentiation and PML-RARα Protein Degradation. Oncotarget. In 6, 25646-59. 2. Zhuang, SL., Bao, LL., Wang, HF., Zhang, M., Yang, C., Zhou, XY., Wu, Y., Rehman, W., Naranmandura, H* (2015) The Involvement of ER-stress and ROS Generation in Difenoconazole-Induced Hepatocellular Toxicity. Toxicol. Res. 4, 1195-1203. (被选为Outside Back Cover). 3. Wang, Q.Q., Thomas, J.D., Naranmandura, H* (2015) The importance of being thiomethylated: formation, fate, and effects of methylated thioarsenicals. Chem. Res. Toxicol. 28, 281-9. (被选为封面文章 Front Cover) 4. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, Wu Y. (2015) Involvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration. Toxicol. Sci. 143, 196-208. 5. Wang, Q.Q., Lan, Y.F., Rehman,K., Jiang, Y.H., Maimaitiyiming, Y., Zhu, D.Y., Naranmandura H* (2015) Effect of Arsenic Compounds on the in Vitro Differentiation of Mouse Embryonic Stem Cells into Cardiomyocytes. Chem. Res. Toxicol. 28, 351-3. 6. Zhang, Y.F., Zhang,M., Huang, X.L., Fu, Y.J., Jiang, Y.H., Bao, L.L., Maimaitiyiming, Y., Zhang, G.J., Wang, Q.Q., Naranmandura H* (2015) The combination of arsenic and cryptotanshinone induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in breast cancer cells. Metallomics 7, 165-173. 1. Naranmandura H* (2014) Letter to the Editor Regarding the Article by Dheeman et al., 2014. Chem. Res. Toxicol. 27, 2011. 2. Rehman, K., Fu, Y.J., Zhang, Y.F., Wang, Q.Q., Wu, B., Wu, Y., Zhou, X.Y., Sun, W.H., Sun, T.F., Naranmandura, H* (2014) Trivalent methylated arsenic metabolites induce apoptosis in human myeloid leukemic HL-60 cells through generation of reactive oxygen species. Metallomics 6, 1502-1512. 3. Banerjee, M., Carew, M.W., Roggenbeck, B.A., Whitlock, B.D., Naranmandura, H., Le, X.C., Leslie, E.M. (2014) A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII). Mol. Pharmacol. 86, 168-179.