孟卓贤 - 浙江大学

个人简介

教育经历 2004/09–2009/07，南京医科大学，生物化学与分子生物学系，博士 1999/09–2004/07，南京医科大学，临床医学系，学士科研与学术工作经历 2015/10–至今，浙江大学，医学院病理与病理生理学系，研究员 2014/02–2015/09, 美国密歇根大学，研究员（Research Investigator) 2009/07–2014/01, 美国密歇根大学，博士后

研究领域

目前课题组重点研究在正常生理情况下和糖尿病发病过程中细胞能量感受（nutrient sensing）和代谢重编程（metabolic reprogramming）的转录调控和信号转导机制，及其在糖尿病发生发展过程中的作用，从而为糖尿病的诊断和治疗提供理论基础和新的药物靶标。肥胖和2型糖尿病及其并发症的分子机制；表观遗传学（染色质重塑）对细胞能量代谢的调控作用和机制；骨骼肌能量代谢稳态在骨骼肌发育、损伤修复和糖尿病发病过程中的作用和机制；胰岛beta细胞的代谢调控和损伤机制。

近期论文

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1. Meng ZX*, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD* (2015) A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis. Cell Reports. 13: 1-12. *co-corresponding author 2. Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD (2014) The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nature Medicine. 20:1436-43. 3. Meng ZX, Wang L, Xiao Y, Lin JD (2014) The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes. 63:1533-45. 4. Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD (2013) Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nature Medicine. 19: 640-5. 5. Meng ZX, Wang GX, Lin JD (2012) A microRNA circuitry links macrophage polarization to metabolic homeostasis. Circulation.125: 2815-7. 6. Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X (2012) Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines. Diabetologia. 55: 1733-44. 7. Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X (2009) Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction. Endocrinology. 150: 5284-93. 8. Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52: 125-35. 9. Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia. 49: 2959-68.