个人简介
学历和研究经历:
1978.3-1982.12 获浙江医科大学医学系本科医学学士学,
1984.9-1987.10获中国预防医学科学院医学硕士学位(微生物及免疫学),
1993.9-1997.5获浙江医科大学医学博士学位(病理生理学),并先后两次赴(1993.1-1996.7以及1999.12-2001.11)美国乔治城大学(Georgetown University)医学院,做博士后研究及任Research Instructor和Research Assistant Professor。
研究领域
从事神经生物学教学和研究,主要研究方向包括突触功能的细胞和分子机制,着重在谷氨酸受体通道及其相关的信号转导在突触形成和突触可塑性中的作用,如NMDA受体亚单位结构与受体装配、运输和突触定位,NMDA受体介导突触效能增强过程中的细胞内信号传导机制,个体突触形成过程中形态学和分子事件。研究涉及的技术包括分子生物学、细胞生物学和活细胞成像、生化和免疫学、细胞和脑片电生理及行为学等。
近期论文
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1. Su-ya Zhou, Shu-jun Xu, Ying-gang Yan, Hui-mei Yu, Shu-cai Ling, Jianhong Luo(2010) Decreased purinergic inhibition of synaptic activity in a mouse model of Niemann-Pick Disease Type C, Hippocampus, in press
2. Shuang Qiu, Xiao-min Zhang, Jing-yuan Cao, Wei Yang, Ying-gang Yan, Ling Shan, Jie Zheng , and Jian-hong Luo (2009) An Endoplasmic Reticulum Retention Signal Located in the Extracellular Amino-terminal Domain of the NR2A Subunit of N-Methyl-D-aspartate Receptors. J. Biol. Chem. 284(30):20285-98
3. Huayi Bai, Jun Cao, Na Liu, Lin Xu, and Jianhong Luo (2009) Sexual behavior modulates contextual fear memory through dopamine D1/D5 receptors, Hippocampus. 19(3):289-98
4. Liu CQ, Chen Z, Liu FX, Hu DN, Luo JH (2007) Involvement of brain endogenous histamine in degeneration of dopaminergic neurons in 6-hydroxydopamine-lesioned rats, Neuropharmacology 53(7):832-41
5. Wei Yang, Chanying Zheng, Qilin Song, Xiujuan Yang, Shuang Qiu, Chunqing Liu, Zhong Chen, Shumin Duan, and Jianhong Luo (2007) A Three Amino Acid Tail Following the TM4 Region of the N-Methyl-D-aspartate Receptor (NR)-2 Subunits Is Sufficient to Overcome Endoplasmic Reticulum Retention of NR1-1A Subunit J. Biol. Chem. 282(12):9269-78
6. Shuang Qiu, Yu-lin Hua, Fan Yang, Yi-zhang Chen, and Jian-hong Luo(2005) Subunit Assembly of N-Methyl-D-aspartate Receptors Analyzed by Fluorescence Resonance Energy Transfer J. Biol. Chem. 280(26):24923-30
7. Luo JH, Fu ZY, Losi G, Kim BG, Prybylowski K, Vissel B, and Vicini S(2002) Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture, Neurophamacol, 42:306-318, 2002
8. Luo JH, Wang Y, Yasuda RP, Dunah AW, Wolfe BB (1997) The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol Pharmacol 51(1):79-86