Moran-Mirabal, Jose - McMaster University - Department of Chemistry & Chemical Biology

个人简介

B.Sc. 1999, Engineering Physics, ITESM (Monterrey, NL, Mexico) M.Sc. 2001, Biotechnology, ITESM (Monterrey, NL, Mexico) Ph.D. 2007, Applied Physics, Cornell University (Ithaca, NY, USA)

研究领域

Our research focuses on utilizing surface chemistry, micro- and nanofabrication to create functional materials that can be used in a wide variety of applications, such as cell microenvironment engineering, sensing, and other analytical platforms. We combine our fabricated structures with various fluorescence microscopy techniques, such as epifluorescence, TIRF, single molecule tracking, FCS, and FRET, to probe the biomolecular interactions that occur between the structured biomaterials and the cells or biomolecules of interest. Through this approach we aim at understanding the interactions that occur between biomolecules and the role that biomaterial patterns play in nature.

近期论文

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Sonney S, Shek N and Moran-Mirabal JM. (2015) Rapid bench-top fabrication of PDMS/polystyrene microfluidic devices incorporating high-surface-area sensing electrodes. Biomicrofluidics. 9: 026501. DOI: 10.1063/1.4918596 Rose M, Babi M and Moran-Mirabal JM. (2015) The study of cellulose structure and depolymerization through single-molecule methods. Industrial Biotechnology. 11: 16-24. DOI: 10.1089/ind.2014.0019 Luterbacher JS, Moran-Mirabal JM, Burkholder E, and Walker LP. (2015) Modeling enzymatic hydrolysis of lignocellulosic substrates using confocal fluorescence microscopy I: Filter Paper Cellulose. Biotechnology and Bioengineering. 112: 21-31. DOI: 10.1002/bit.25329 Luterbacher JS, Moran-Mirabal JM, Burkholder E, and Walker LP. (2015) Modeling enzymatic hydrolysis of lignocellulosic substrates using confocal fluorescence microscopy II: Pretreated Biomass. Biotechnology and Bioengineering. 112: 32-42. DOI: 10.1002/bit25328 Vanderfleet OM, Gabardo CM, Naeem F, Moran-Mirabal JM, and Soleymani L (2014) Rapid prototyping of a miniaturized electrospinning setup for the production of polymer nanofibers. Journal of Applied Polymer Science. 131: 40629. DOI: 10.1002/app.40629 Abitbol T, Palermo AF, Moran-Mirabal JM, and Cranston ED (2013) Fluorescent labelling and characterization of cellulose nano crystals with varying charge contents. Biomacromolecules. 14: 3278-3284. DOI: 10.1021/bm400879x Moran-Mirabal JM (2013) Advanced-microscopy techniques for the study of cellulose structure and cellulose-cellulase interactions, in Cellulose - Fundamental Aspects. Theo van de Ven and Louis Godbout Eds. InTech Press. ISBN: 978-953-51-1183-2 Yang D, Moran-Mirabal JM, Parlange JY, and Walker LP (2013) Investigation of the porous structure of cellulosic substrates through confocal laser scanning microscopy. Biotechnology and Bioengineering. 110: 2836-2845. DOI: 10.1002/bit.24958 Moran-Mirabal JM (2013) The study of cellulose structure and cellulose-cellulase interactions through fluorescence microscopy. Cellulose. 20: 2291-2309. DOI: 10.1007/s10570-013-0010-8 Gabardo CM, Zhu Y, Soleymani L, and Moran-Mirabal JM (2013) Benchtop fabrication of hierarchically structured high surface area electrodes. Advanced Functional Materials. 23: 3030-3039. DOI: 10.1002/adfm.201203220 Moran-Mirabal JM, Bolewski JC, and Walker LP. (2013) Cellulases exhibit limited surface diffusion on bacterial microcrystalline cellulose. Biotechnology and Bioengineering. 110: 47-56. DOI: 10.1002/bit.24604 Luterbacher JS, Walker LP, Moran-Mirabal, JM. (2013) Observing and modeling BMCC degradation by commercial cellulase cocktails with fluorescently labeled Trichoderma reseii Cel7A through confocal microscopy. Biotechnology and Bioengineering. 110: 108-117. DOI: 10.1002/bit.24597 Zhu Y, Moran-Mirabal JM. (2012) Micro and Nanostructured Materials for the Study and Monitoring of Biomolecular interactions. Laboratory Focus. 16 (4): 13-15. Kostylev M, Moran-Mirabal JM, Walker LP, and Wilson DW. (2012) Determination of the molecular states of the processive endocellulase Thermobifida fusca Cel9A during crystalline cellulose depolymerization. Biotechnology and Bioengineering. 109: 295-299. DOI: 10.1002/bit.23299 Zhu P, Moran-Mirabal JM, Luterbacher JS, Walker LP, and Craighead HG. (2011) Observing Thermobifida fusca cellulase binding to pretreated wood particles using time-lapse confocal laser scanning microscopy. Cellulose. 18: 749-758. DOI: 10.1007/s10570-011-9506-2 Moran-Mirabal JM, Bolewski JC, and Walker LP. (2011) Reversibility and binding kinetics of Thermobifida fusca cellulases studied through fluorescence recovery after photobleaching microscopy. Biophysical Chemistry. 155: 20-28. DOI: 10.1016/j.bpc.2011.02.003 Moran-Mirabal JM, Corgie SC, Bolewski JC, Smith HM, Cipriany BR, Craighead HG, Walker LP. (2009) Labeling and purification of cellulose-binding proteins for high resolution fluorescence applications. Analytical Chemistry. 81: 7981-7987. DOI: 10.1021/ac901183b Moran-Mirabal JM, Santhanam N, Corgie SC, Craighead HG, and Walker LP. (2008) Immobilization of cellulose fibrils on solid substrates for cellulase binding studies through quantitative fluorescence microscopy. Biotechnology and Bioengineering. 101: 1129 - 1141. DOI: 10.1002/bit.21990 Slinker JD, DeFranco JA, Jaquith MJ, Silveira WR, Zhong YW, Moran-Mirabal JM, Craighead HG, Abruña H, Marohn JA, and Malliaras GG. (2007) Direct measurement of the electric-field distribution in a light-emitting electrochemical cell. Nature Materials. 6: 894-899. DOI: 10.1038/nmat2021 Moran-Mirabal JM, Aubrecht DM, and Craighead HG. (2007) Phase separation and fractal domain formation in phospholipid/diacetylene supported lipid bilayers. Langmuir. 23:10661-10671. DOI: 10.1021/la701371f