个人简介
李永泉,教授、博导，浙江大学求是特聘教授，国务院政府特殊津贴专家，浙江大学药物生物技术研究所所长，浙江省微生物生化与代谢工程重点实验室主任、浙江省微生物制药技术工程实验室主任，入选“浙江省151人才工程”重点层次。中国微生物学会理事兼分子微生物专业委员会副主任委员，中国生物工程学会合成生物学专业委员会委员，浙江省微生物学会理事长。2012.01- 浙江大学求是特聘教授、博导 2009.12- 浙江省微生物生化与代谢工程重点实验室主任 2013.12- 浙江省微生物制药技术工程实验室主任 2016.1- 浙江大学药物生物技术研究所所长,教授、博导 2002.12-2015.12浙大生命科学学院教授、博导，生化研究所所长， 2010.10-2010.10 美国康乃尔大学营养系高级访问学者 2007.02-2007.03 美国威斯康星大学药学院高级访问学者 2001.06-2002.06 美国明尼苏达大学联培博士生 1999.03-2003.06 浙江大学生物工程专业博士生 1998.09-2002.12 浙江大学生命科学学院副教授、硕导 1995.05-1998.01 浙江佐力药业有限公司总工程师 1992.04-1998.09 杭州大学生科院讲师、副教授，副所长 1989.09-1992.03 浙江大学生物工程专业硕士研究生
近期论文
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[1] Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou，Xin-Hang Jiang, Xu-Ming Mao，Shui-Ping Liu，Wen-Jun Guan, Yong-Quan Li，Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10, Molecular Microbiology，2017， 103(4), 713–728
[2] Xu-Ming Mao, Shuai Luo, Ri-Cheng Zhou, Feng Wang, Pin Yu, Ning Sun, Xiao-Xia Chen, Yi Tang and Yong-Quan Li*，Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator AtrA，Journal of Biological Chemistry, 2015, 290（12）:7992–8001.
[3] Xu-Ming Mao, Wei-Hong Feng, Ning Sun, Zhan Zhou and Yong-Quan Li*. Dual Positive Feedback Regulation of Protein Degradation of an ECF (extra-cytoplasmic function) Sigma Factor for Cell Differentiation in Streptomyces coelicolor, Journal of Biological Chemistry, 2013,288（43）：31217-31228
[4] Peng-Hui Yuan, Ri-Cheng Zhou, Xuepeng Chen, Shuai Luo, Feng Wang, Xu-Ming Mao*,Yong-Quan Li*, DepR1, aTetR-family transcriptional regulator, positively regulates daptomycin production in an industrial producer Streptomyces roseosporusSW0702, Applied and Environmental Microbiology, 2016，82(6):1898-1905
[5] Yue-Yue Wang, Xiao-Sheng Zhang, Hong-Dou Luo,, Ni-Ni Ren, Xin-Hang Jiang,Hui Jiang, Yong-Quan Li, Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network, Scientific Reports, 2016 Apr 7;6:24255.
[6] Hui Jiang, Yue-Yue Wang, Wei-Ming Fan, Xin-Hang Jiang,Wen-Jun Guan,* and Yong-Quan Li*. Improvement of Natamycin Production by Engineering of Phosphopanteth Transferases in Streptomyces chattanoogensis L10, Applied and Environmental Microbiology, 2013, 79（11）：3346-3354
[7] Yi-Ling Du,Xue-Ling Shen,Pin Yu,Lin-Quan Bai,and Yong-Quan Li*. Gamma-Butyrolactone Regulatory System of Streptomyces chattanoogensis Links Nutrient Utilization,Metabolism and Developmental Programme, Applied and Environmental Microbiology, 2011,77（23）：8415-8426
[8] Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang , Yong-Quan Li*, WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology, 2014,80(22):6879-6887;
[9] Guo, Yuanyang; Li, Han; Zhou, zhenxing; Mao, Xu-Ming; Tang, Yi; Chen, Xin; Jiang, Xin-Hang; Liu, Yu; Jiang, Hui; Li, Yong-Quan*. Identification and Biosynthetic Characterization of Natural Aromatic Azoxy Products from Streptomyces chattanoogensis L10,Organic Letters, 2015, 17:6114−6117
[10] Shui-Ping Liu，Pin Yu, Peng-Hui Yuan，Zhen-Xing Zhou,Qing-Ting Bu, Xu-Ming Mao and Yong-Quan Li*, Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10, Applied Microbiology and Biotechnology, 2015,99(6):2715-2726;
[11] Zhen-Xing Zhou,Qing-Qing Xu,Qing-Ting Bu,Shui-Ping Liu, Pin Yu, Yong-Quan Li*, Transcriptome-guided identification of SprA as a pleiotropic regulator in Streptomyces chattanoogensis , Applied Microbiology and Biotechnology, 2015，99 (3):1287-1298;
[12] Zhen-Hong Zhu, Han Li, Pin Yu，Yuan-Yang Guo, Shuai Luo, Zhong-Bin Chen, Xu-Ming Mao, Wen-Jun Guan, Yong-Quan Li*, SlnR is a positive pathway-specific regulator for salinomycin, Appl Microbiol Biotechnol, 2016,100(23)：1898-1905
[13] Zhenxing Zhou,Qingqing Xu,Qingting Bu,Yuanyang Guo,Shuiping Liu,Yu Liu,Yiling Du,Yongquan Li*, Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster inStreptomyces chattanoogensis, ChemBioChem, 2015, 16(3):496-502
[14] Xu-Ming Mao, Zhi-Hao Sun, Bi-Rong Liang, Zhi-Bin Wang, Fang-Liang Huang, Yong-Quan Li*. Positive feedback regulation of StgR expression for secondary metabolism in Streptomyces coelicolor, Journal of Bacteriology, 2013,195（9）：2072-2078.
[15] Yi-Ling Du, Shan-Zhen Li, Zhan Zhou, Shi-Fei Chen, Wei-Min Fan, Yong-Quan Li*.The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis. Microbiology-sgm, 2011, 157: 1300–1311
[16] Jiang H, Wang YY, Guo YY, Shen JJ, Zhang XS, Luo HD, Ren NN, Jiang XH, Li YQ*. An Acyltransferase Domain of FK506 Polyketide Synthase Recognizing Both an Acyl Carrier Protein and Coenzyme A As Acyl Donors To Transfer Allylmalonyl and Ethylmalonyl Units. FEBS J. 2015, 282: 2527–2539
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