个人简介
1991年7月毕业于浙江医科大学临床医学(五年制)系后,留校攻读肿瘤学硕士(1996-1999)。1999年7月始在浙江大学医学院附属邵逸夫医院肿瘤内科从事临床工作,2001年晋升主治医师。2001年12月-2004年11月在德国karlsruhe大学攻读分子肿瘤学博士。2004年12月-2007年10月先后在德国Jena分子生物技术研究所和中国香港中文大学肿瘤学系从事博士后工作。2007年11月-2009年10月在香港中文大学消化病研究所任研究助理教授,研究小组组长(PI)。2009年11月始获聘浙江大学求是特聘教授并全职回国工作。
近期论文
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1. Jin H., Sperka T., Herrlich P. and Morrison H. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 2006;442(7102):576-9 (IF:36.1)
2. Jin H.*, Wang X.*, Ying J., Wong AH, Li H, Lee KY, Chan AT, Yeo W, Ma BB, Lung ML, Shen ZY, Xu LY, Langford C and Tao Q. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in multiple carcinomas. Oncogene. 2007;26(53):7490-7498 (IF:7.2)
3. Jin H., Wang X, Ying J, Wong AH, Cui Y, Shen ZY, Li EM, Zhang Q, Jin J, Kupzig S, Chan AT, Cullen PJ and Tao Q. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in cancers. Proceedings of the National Academy of Sciences 2007;104(30):12353-8 (IF:9.8)
4. Cheng YY*, Jin H*, Liu X, Siu JM, Wong YP, Ng EK, Yu J, Leung WK, Sung JJ and Chan FK. Fibulin 1 (FBLN1) is downregulated through promoter hypermethylation in gastric cancer. British J. of Cancer. 2008;99(12):2083-2087 *: 共同第一作者 (IF:4.9)
5. Liu X, Lam EK, Wang X, Zhang JB, Cheng YY, Lam YW, Ng EKO, Yu J, Chan FKL, Jin HC* and Sung JJY. Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer. Tumor Biology 2009;242-248 *:通讯作者 (IF:2.0)
6. Wang X, Lam EK, Zhang JB, Jin HC*, Sung JJ. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers Biochem Bioph Res Com 2009; 387(2):376-380 *:通讯作者 (IF:2.6)
7. Wang LJ, Jin HC*, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ*. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Bioph Res Com 2009;379(4):959-63 *:通讯作者 (IF:2.6)
8. Wang X and Jin H*. The epigenetic basis of Warburg effect Epigenetics 2010;5(7):566-568 *:通讯作者 (IF:4.7)
9. Liu X, Wang X, Zhang JB, Lam EK, Shin VY, Cheng YY, Cheng AS, Yu J, Chan FK, Sung JJ and Jin HC*. Warburg effect revisited: an epigenetic link between aerobic glycolysis and gastric carcinogenesis Oncogene 2010;29:442-450 *:通讯作者 (IF:7.2)
10. Han W, Sun J, Feng L, Wang K, Li D, Pan Q, Chen Y, Jin W, Wang X, Pan H* and Jin H*. Autophagy Inhibition Enhances Daunorubicin-induced Apoptosis in K562 cells PLoS One 2011;e028491 *: 通讯作者 (IF:4.8)
11. Feng LF, Wang X* and Jin HC*. Rabbit monoclonal antibody: potential application in cancer therapy American Journal of Translational Research 2011;3(3):269-274 *: 通讯作者
12. Han W, Pan H*, Chen Y, Sun J, Wang Y, Li J, Ge W, Feng L, Lin X, Wang XJ, Wang X, Jin H*. EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells PLoS One 2011;6(6):e18691 *:通讯作者 (IF:4.8)
13. Lam EK, Wang X*, Shin V, Zhang S, Morrison H, Sun J, Ng EK, Yu J and Jin H*. A microRNA contribution to aberrant Ras activation in gastric cancer. American Journal of Translational Research 2011;3(2):209-218 *:通讯作者
14. Wang L, Wang X*, Wang XJ, Pan J, Lu HQ, Zhang SJ, Lin XY, Lam EK, Cui Y, Yu J and Jin HC*. Klotho is silenced through promoter hypermethylation in gastric cancer American Journal of Cancer Research 2011;1(1):111-119 *:通讯作者
15. Zhang S, Jiang T, Feng L, Sun J, Lu H, Wang Q, Pan M, Huang D, Wang X, Wang L* and Jin H*. Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha Journal of Molecular Medicine 2012 Sep;90(9):1069-77 *: 通讯作者 (IF:5.2)
16. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, Lam E, Liu X, Zhang J, Zhou T, Yu J, Jin H* and Si J*. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis Molecular Medicine 2012 May 9;18(1):389-400 *: 通讯作者 (IF:5.9)
17. Feng L, Pan M, Sun J, Lu H, Shen Q, Zhang S, Jiang T, Liu L, Jin W, Chen Y, Wang X*, Jin H*. Downregulation of p53 Up-regulated Modulator of Apoptosis by histone deacetylase 3 in gastric cancer Journal of Molecular Medicine 2012 Accepted *: 通讯作者 (IF: 5.2)