Li, Yingfu - McMaster University - Department of Biochemistry and Biomedical Sciences

个人简介

Ph. D. Chemistry and Biochemistry, Simon Fraser University, 1997 M. Sc. Applied Chemistry, Beijing Agriculture University (Present name: China Agriculture University), 1989 B. Sc. Chemistry, Anhui University, 1983 Current Status: Professor, Department of Biochemistry and Biomedical Sciences Joint Member, Department of Chemistry and Chemical Biology Canada Research Chair in Chemical Biology of Nucleic Acids Member, Brockhouse Institute for Materials Research Member, Centre for Functional Genomics Member, Origins Institute Member, School of Biomedical Engineering Member, Biointerfaces Institute Member, Michael G. DeGroote Institute for Infectious Disease Research Associate Editor, Journal of Molecular Evolution (2013- Brief Biography: Yingfu Li was born and raised in Anhui, China. He received his B. Sc. in chemistry at Anhui University in 1983, and his M. Sc. in applied chemistry at Beijing Agriculture University in 1989, under the supervision of Changhai Zhou. He moved to Canada in 1992, and in 1997, he graduated with a Ph.D. in chemistry and biochemistry at Simon Fraser University under the supervision of Dipankar Sen. He then did his postdoctoral research with Ronald R. Breaker at Yale University. In 1999, he joined McMaster University, where he is currently a Professor in the Department of Biochemistry and Biomedical Sciences and the Department of Chemistry and Chemical Biology. Outside of the office, he enjoys playing golf, rain or shine.

研究领域

My research focuses on nucleic acids structure and function, in vitro evolution, catalytic DNA, catalytic RNA, DNA and RNA aptamers, riboswitches, non-coding RNA, bacterial toxins, enzymology, nucleic acids engineering, molecular diagnostics, biosensors, organic synthesis, high-throughput screening, nanoparticles, DNA nanotechnology and spectroscopy.

近期论文

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Li J, Li Y* (2021). Facile Synthesis of Pd-Ir Nanocubes for Biosensing. Frontiers in Chemistry. Manuscript ID: 775220. Accepted. Yousefi H, Esmaeili Samani S, Prasad A, Shakeri A, Li Y, Filipe CDM,* Didar T.* (2021). LISzymes Biosensors: DNAzymes Embedded in an Anti-Biofouling Platform for Hands-Free Real-Time Detection of Bacterial Contamination in Milk. ACS Nano. Manuscript ID: ID nn-2021-05766f. Accepted. Bialy R, Li Y,* Brennan JD.* (2021). Target-Mediated 5’-Exonuclease Digestion of DNA Aptamers with RecJ to Modulate Rolling Circle Amplification for Biosensing. ChemBioChem. doi: 10.1002/cbic.202100476. Zhang Z, Pandeya R, Li J, Gu J, White D, Stacey HD, Ang JC, Steinberg C-J, Capretta A, Filipe CDM, Mossman KL, Balion C, Miller MS, Salena BJ, Yamamura D, Soleymani L,* Brennan JD,* Li Y.* (2021). High Affinity Dimeric Aptamers Enable Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva. Angew Chem Int Ed. 60(45):24266-24274. doi: 10.1002/anie.202110819. Khan S, Burciu B, Filipe CDM, Li Y, Dellinger K,* Didar T.* (2021). DNAzyme-based Biosensors: Immobilization Strategies, Applications and Future Prospective. ACS Nano. 5(9):13943-13969. DOI: 10.1021/acsnano.1c04327. . Qi L, Yang M, Chang D, Zhao W, Zhang S, Du Y,* Li Y.* (2021). A DNA Nanoflower Assisted Separation-free Nucleic Acid Detection Platform with Commercial Pregnancy Test Strip. Angew Chem Int Ed. 60(47):24823-24827. DOI: 10.1002/anie.202108827. Chang D, Zakaria S, Esmaeili Samani S, Chang Y, Filipe CDM, Soleymani L, Brennan JD, Liu M,* Li Y.* (2021). Functional Nucleic Acids for Pathogenic Bacteria Detection. Accounts of Chemical Research. 54(18):3540-3549. DOI: 10.1021/acs.accounts.1c00355. Bialy R, Li Y,* Brennan JD.* (2021). Target-Dependent Protection of DNA Aptamers Against Nucleolytic Digestion Enables Signal-On Biosensing with Toehold-Mediated Rolling Circle Amplification. Chem. Euro. J. chem.202102975. Zhao D, Chang D, Zhang Q, Chang Y, Liu B, Sun C, Li Z, Dong C, Liu M,* Li Y.* (2021). Rapid and Specific Imaging of Extracellular Signaling Molecule Adenosine Triphosphate with a Self-Phosphorylating DNAzyme. J Am Chem Soc. 143(37):15084-15090. doi: 10.1021/jacs.1c04925. Li J, Zhang Z, Gu J, Stacey HD, Ang JC, Capretta A, Filipe CDM, Mossman KL, Balion C, Salena BJ, Yamamura D, Soleymani L, Miller MS, Brennan JD,* Li Y.* (2021). Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library. Nucleic Acids Res. 49(13):7267-7279. doi: 10.1093/nar/gkab574. McConnell EM, Cozma I, Mou Q, Lu Y,* Brennan JD,* Li Y.* (2021). Biosensing with DNAzymes. Chem Soc Rev. 50(16):8954-8994. doi: 10.1039/d1cs00240f. Zhang Y, Zhang Q, Cheng F, Chang Y, Liu M,* Li Y. (2021). Fast-Responding Functional DNA Superstructures for Stimuli-Triggered Protein Release. Chem Sci. 12(24):8282-8287. doi: 10.1039/d1sc00795e. Pandeya R, Chang D, Smiejac M, Hoare T, Li Y,* Soleymania L.* (2021). Integrating programmable RNA-cleaving DNAzymes with electrical readout enables rapid and culture-free bacterial detection using a handheld platform. Nat. Chem. 13(9):895-901. doi: 10.1038/s41557-021-00718-x Chang T, He S, Amini R, Li Y.* (2021). Functional Nucleic Acids Under Unusual Conditions. ChemBioChem. 22(14):2368-2383 doi: 10.1002/cbic.202100087. Samani SE, McConnell EM, Chang D, Rothenbroker M, Filipe CD,* Li Y.* (2021). A Syringe-Based DNAzyme Sensor for Bacterial Detection. Analysis & Sensing. 2021, 1, 95 – 100. https://doi.org/10.1002/anse.202100006 Li J, Li Y.* (2021). One-pot high-yield synthesis of Pd nanocubes for Pd-Ir nanocube-based immunoassay of nucleocapsid protein from SARS-CoV-2. Anal. Bioanal. Chem. 413(18):4635-4644 DOI: 10.1007/s00216-021-03265-z.