高向伟 - 浙江大学

个人简介

教育经历： 2002/9 - 2007/12，浙江大学，生物化学与分子生物学，博士 1997/9 - 2002/7，滨州医学院，临床医学二系，学士工作经历： 2012/1 - 至今，浙江大学，医学院，副教授 2012/2 - 2016/12，美国康奈尔大学，营养系，博士后 2011/6 - 2011/9，美国奥尔巴尼医学院，访问学者 2010/7 - 2011/12，浙江大学，医学院，讲师 2008/1 - 2010/6，浙江大学，医学院，博士后

研究领域

长期从事细胞应激（化学物、热应激、营养物质缺乏等）时mRNA翻译的分子调控机制及生物学意义研究。主要发现包括： 1）建立了评价蛋白质翻译起始效率的方法，并系统研究营养物质缺乏时翻译起始改变； 2）发现翻译起始后核糖体在mRNA上存在停留，该事件是应激时细胞调节蛋白质翻译延伸过程的重要机制； 3）鉴定卵泡抑素为一核仁蛋白，并发现该蛋白在细胞应激时通过抑制核糖体生成而抑制蛋白质翻译。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Zhang L, Han B, Xiang J, Liu K, Dong H, Gao X (通讯作者). Silica nanoparticle releases SIRT6-induced epigenetic silencing of follistatin. Int J Biochem Cell Biol. 2018. 95:27-34. [2] Zhang L, Liu K, Han B, Xu Z, Gao X (通讯作者). The emerging role of follistatin under stresses and its implications in diseases. Gene. 2018. 639:111-6. (Review) [3] Li S, Chen Y, Sun D, Bai R, Gao X, Yang Y, Sheng J, Xu Z. Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs. Mol Neurobiol. 2018. 55:1338-51. [4] Lin C, Zhao X, Sun D, Zhang L, Fang W, Zhu T, Wang Q, Liu B, Wei S, Chen G, Xu Z, Gao X (通讯作者). Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress. Sci Rep. 2016. 6:21133. [5] Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR, Qian SB. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature. 2015. 526:591-4. [6] Zhang X, Gao X, Coots RA, Conn CS, Liu B, Qian SB. Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nat Struct Mol Biol. 22:404-10. [7] Gao X, Wan J, Liu B, Ma M, Shen B, Qian SB. Quantitative profiling of initiating ribosomes in vivo. Nat Methods. 2015. 12:147-53. [8] Gao X (共同通讯作者), Dong H, Lin C, Sheng J, Zhang F, Su J, Xu Z. Reduction of AUF1-mediated follistatin mRNA decay during glucose starvation protects cells from apoptosis. Nucleic Acids Res. 2014. 42:10720-30. [9] Han Y#, Gao X# (共同第一作者), Liu B, Wan J, Zhang X, Qian SB. Ribosome profiling reveals sequence-independent post-initiation pausing as a signature of translation. Cell Res. 2014. 24:842-51. [10] Ang J, Sheng J, Lai K, Wei S, and Gao X (通讯作者). Identification of estrogen receptor-related receptor gamma as a direct transcriptional target of angiogenin. PLoS One. 2013. 8: e71487. [11] Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon EY, Zhi X, Xu Z, Lennartz MR, Barroso M, Trebak M, Chen C, and Zhou J. The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol. 2012. 32: 2662-9. [12] Wei S, Gao X, Du J, Su J, and Xu Z. Angiogenin enhances cell migration by regulating stress fiber assembly and focal adhesion dynamics. PLoS One. 2011. 6: e28797. [13] Gao X, Wei S, Lai K, Sheng J, Su J, Zhu J, Dong H, Hu H, and Xu Z. Nucleolar follistatin promotes cancer cell survival under glucose-deprived conditions through inhibiting cellular rRNA synthesis. J Biol Chem. 2010. 285: 36857-64. [14] Qian J, Wang Y, Gao X, Zhan Q, Xu Z, and He S. Carboxyl-functionalized and bio-conjugated silica-coated quantum dots as targeting probes for cell imaging. J Nanosci Nanotechnol. 2010. 10: 1668-75. [15] Qian J, Li X, Wei M, Gao X, Xu Z, and He S. Bio-molecule-conjugated fluorescent organically modified silica nanoparticles as optical probes for cancer cell imaging. Opt Express. 2008. 16: 19568-78. [16] Gao X and Xu Z. Mechanisms of action of angiogenin. Acta Biochim Biophys Sin. 2008. 40: 619-24. [17] Zhang H, Gao X, Weng C, and Xu Z. Interaction between angiogenin and fibulin 1: evidence and implication. Acta Biochim Biophys Sin. 2008. 40: 375-80. [18] Gao X, Hu H, Zhu J, and Xu Z. Identification and characterization of follistatin as a novel angiogenin-binding protein. FEBS Lett. 2007. 581: 5505-10. [19] Zeng Q, Ke X, Gao X, Fu Y, Lu D, Chiang H, and Xu Z. Noise magnetic fields abolish the gap junction intercellular communication suppression induced by 50 hz magnetic fields. Bioelectromagnetics. 2006. 27: 274-9. [20] Hu H, Gao X, Sun Y, Zhou J, Yang M, and Xu Z. Alpha-actinin-2, a cytoskeletal protein, binds to angiogenin. Biochem Biophys Res Commun. 2005. 329: 661-7.