范伟民 - 浙江大学

个人简介

学习经历：　　 1978-1983 浙江医科大学医学系本科学生　　 1983-1986 浙江医科大学公共卫生学系硕士研究生　　 1986-1988 美国迈阿密大学医学院微生物和免疫系博士研究生　　 1988-1990 美国南卡罗莱纳大学医学院微生物和免疫系博士研究生　　 1990-1992 美国南卡罗莱纳医科大学风湿病和免疫学博士后工作经历：　　 1992-1997 美国南卡罗莱纳医科大学内科及病理与实验医学系助理教授　　 1992-2014 美国南卡罗莱纳医科大学研究生院博士生导师　　 1994-2014 美国南卡罗莱纳医科大学Hollings癌症中心 Full Member 　　 1997-2003 美国南卡罗莱纳医科大学病理与实验医学系及内科系副教授　　 2003-2014 美国南卡罗莱纳医科大学病理与实验医学系及内科系教授　　 2004-2005 教育部春晖计划讲座教授（浙江大学医学院）　　 2005-2008 浙江大学兼职教授，肿瘤学博士生导师　　 2008-目前浙江大学求是特聘教授，博士生导师

研究领域

肿瘤生物学, 激素对肿瘤生长和治疗的影响，肿瘤靶向治疗，纳米抗感染药物等

近期论文

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1.Fan W., Kasahara M., Gutknecht J., Klein D., Jonkers J., and Klein J. Shared class II MHC polymorphisms between human and chimpanzees. Human Immunol. 26:107-121, 1989 2. Kasahara M, Klein D, Fan W, Gutknecht J.Evolution of the class II major histocompatibility complex alleles in higher primates, Immunol Rev. 113:65-82.1990 3． Fan W., Trifilette R. Cooper T. and Norris JS. Cloning of a µ class glutathione S-transferase gene and identification of the glucocorticoid regulatory domains in its 5’flanking region. Proc. Natl. Acad. Sci. U.S.A. 89:6104-6108, 1992 4. Fan, W., Cooper, T. and Norris, JS. Characterization of selective glucocorticoid dependent responses in a glucocorticoid resistant smooth muscle tumor cell line. J. Cell. Physiol. 156:88-95, 1993 5. Johnson KR., Wang L., Miller MC., Willingham MC. Fan W.* 5-Flurouracil interferes with paclitaxel cytotoxicity against human solid tumor cells. Clin. Cancer Res. 3:1739-1745, 1997 6. Fan W.*, Ma JX. and Norris JS. Molecular cloning of TA16, a transcription repressor, that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells, Mol. Endocrin. 11:1342-1352, 1997 7. Fan, W.*, Kou, H., Shen, D. and LeRoy, EC. Identification of altered expression of ADT/ATP translocase and laminin during cellular senescence in vitro. Exp. Geront. 33:457 465, 1998 8. Johnson RK., Young KK, and Fan W.* Antagonistic interplay between anti-mitotic and G1/S arresting agents in experimental combination therapy. Clin. Cancer Res. 5:2559-2565, 1999 9. Fan W.* Possible mechanisms of paclitaxel-induced apoptosis, Biochem. Pharmacol, 57:1215-1221, 1999 10. Huang Y. Johnson RK, Norris JS. and Fan W.* Nuclear factor-kappaB/I-kB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res. 60:4426-4432, 2000 11. Zeng S., Chen YZ, Johnson, KR. and Fan W.* In vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin. Cancer Res. 6:3766-3773, 2000 12. Huang Y. and Fan, W.* IkB kinase activation is involved in the regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol. 61:105-113, 2002 13. Sui M., Dziadyk J., Zhu XM, and Fan W.* Cell cycle dependent antagonistic interactions between paclitaxel and gama-radiation in combination therapy. Clin. Cancer Res. 10:4848-4857, 2004 14． Fan W.* Sui M. and Huang Y. Glucocorticoids inhibit taxane-induced apoptosis: Mechanisms and clinical impact. Curr. Med. Chem. 11:403-411, 2004 15. Huang Y. Fang Y. Wu J., Dziadyk J., Zhu XM, Sui M., and Fan W.* Regulation of vinca alkaloid-induced apoptosis by NF-kappaB/IkB pathway in human tumor cells. Mol. Cancer Therap. 3: 271-277, 2004. 16． Sui M. and Fan W.* Combination of gamma-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on both mitotic arrest ad apoptosis. Int. Radio. Oncol. Phy. Bio. 1151-1158, 2005 17. Sui M., Chen F., Chen Z. and Fan, W.* Glucocorticoids interfere the therapeutic efficacy of paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer. 119-712-717, 2006 18. Sui M. Huang Y., Park BH, Davidson NE., Fan W.* Estrogen receptor-alpha mediates breast cancer cells resistance to paclitaxel through inhibition of apoptotic cell death. Cancer Res. 67: 5337-5344, 2007.