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个人简介

1982.09-1985.08 南通医学院生理学专业硕士研究生 1985.09-2000.01 南通医学院航海医学研究所教师 1992.04 晋升副研究员 1988.10-1991.03 日本九州大学医学部生理学专业博士研究生 2000.01-2009.03 中国科学院神经科学研究所工作2000.03晋升研究员 2007.11 当选中国科学院院士 2008.11 当选第三世界科学院院士 2009.03-2009.09 中国科学院神经科学研究所副所长 2009.09-2013.06 浙江大学医学部主任 2013.06-2018.01 浙江大学医学院院长兼医学中心(筹)主任 2013至今 浙江大学医药学部主任,第十一届、第十二届、第十三届全国政协委员,第十一届、第十二届浙江省政协委员

研究领域

神经元-胶质细胞相互作用 情绪及相关疾病的神经环路解析 神经信号传递机制

近期论文

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Xia Li, Liming Qin,Yefei Li, Hao Yu,Zhijun Zhang, Changlu Tao, Yijun Liu, Yanhong Xue, Xiaoxing Zhang, Zhenghao Xu, Yi Wang, Huifang Lou, Zhibin Tan, Paul Saftig, Zhong Chen, Tao Xu, Guoqiang Bi, Shumin Duan*, Zhihua Gao*. PresynapticEndosomalCathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Cell Reports. 2019 Jul 23;28(4):1015-1028. Tan Z, Liu Y, Xi W, Lou HF, Zhu L, Guo Z, Mei L, Duan S*. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nat Commun, 2017, 8: 13772. Yang H, Yang J, Xi W, Hao S, Luo B, He X, Zhu L, Lou H, Yu YQ, Xu F, Duan S*, Wang H*. Laterodorsaltegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.[J]. Nat Neurosci, 2016, 19(2): 283-289. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan S*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. J Neurosci. 2015, 35(6):2674-2688. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng GP, Huang ZL, Duan S*, Yu YQ*, Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep wake Transitions, Curr Biol. 2014,24: 693-698 Wu HJ, Liu YJ, Li HQ, Chen C, Dou Y, Lou HF, Ho MS, Li XM, Gao Z*, Duan S. Analysis of microglial migration by a micropipette assay. Nat Protoc. 2014, 9: 491-500. Li HQ, Chen C, Dou Y, Wu HJ, Liu YJ, Lou HF, Zhang JM, Li XM, Wang H, Duan S*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Mol Cell Biol. 2013, 33: 4282-93. Chen J, Tan Z, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S*.Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. 2013, 61:178-191. Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S*, Zheng J*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem Cells. 2012, 30:2571-2583. Y Dou, HJ Wu, HQ Li, S Qin, HF Lou, QM Luo, Duan S*, Microglia Migration Mediated by ATP-Induced ATP Release from Lysosome, Cell Res, 2012 22:1022-1033. Song AH, Wang D, Chen G, Li Y, Luo J, Duan S*, Poo MM. A selective filter for cytoplasmic transport at the axon initial segment. Cell. 2009, 136(6):1148-1160. Tong XP, Li XY, Zhou B, Shen WH, Zhang ZJ, Xu TL, Duan S*,Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J Cell Biol. 2009, 186(1): 113-128. Li H, Chen G, Zhou B, Duan S*. Actin Filament Assembly by MARCKS- PI(4,5)P2 Signaling Is Critical for Dendrite Branching. MolBiol Cell. 2008, 19(1): 4804-4813. Zhang ZJ, Chen G, Zhou W, Song AH, Wang W, Xu T, Luo QM, Gu XS, Duan S*, Regulated ATP release from astrocytes via lysosome exocytosis. Nat Cell Biol.2007, 9(8): 945-953. Chen G, Li HM, Chen YR, Gu XS, Duan S*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 2007; 55(15)):1509-1518. Ge WP, Yang XJ, Zhang ZJ, Wang HK, Deng QD, Duan S*. Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors. Science, 2006,312, 1533-1537. Shen W, Wu B, Zhang Z, Dou Y, Rao ZR, Chen YR, Duan S*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron, 2006, 50(3): 401-414 (Cover article) Duan S*,Neary J, P2X7/P2Z receptors: properties and relevance to CNS functions (Invited review). Glia, 2006, 54:738-746. Li, C., Wu, CP., Duan S*, and Poo, M*. Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron, 2004, 41(2), 257-268. Zhang J, Wang H Ye C, Ge W, Chen Y, Wu CP, Poo M, and Duan S*.ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron,2003, 40 (5), 971-982.

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