杜艺岭 - 浙江大学

个人简介

杜艺岭，浙江大学基础医学院微生物系和药物生物技术研究所“百人计划”研究员，博士生导师，入选国家级人才计划青年项目、国家自然科学基金委优秀青年基金项目和浙江省杰出青年基金项目。实验室长期聚焦于研究与人体健康密切相关的微生物合成代谢过程的生化分子机理、微生物源药物的生物合成机理及其在生物医药与合成生物学领域的应用，近年来以通讯作者在《自然化学生物学》、《自然通讯》和《德国应用化学》等国际权威杂志上发表了多篇研究论文。

研究领域

重要微生物次级代谢过程的遗传与生物化学机理微生物源功能小分子（致病因子和抗生素等）的发现与合成代谢机理微生物基因组学驱动的药物发现与合成生物学制造

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wei Li, Ziyang Cheng, Zhijie Zhao, Hu Li, Yu Liu, Xingyu Lu, Guiyun Zhao, Yi-Ling Du* (2024) Discovery of a a bacterial hydrazine transferase that constructs the N‑aminolactam pharmacophore in albofungin biosynthesis. Journal of the American Chemical Society, doi: 10.1021/jacs.4c02311. Xinjie Shi, Guiyun Zhao, Hu Li, Zhijie Zhao, Wei Li, Miaolian Wu, Yi-Ling Du* (2023) Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria. Nature Chemical Biology, doi: 10.1038/s41589-023-01416-0. Jingkun Shi, Xin Zang, Zhijie Zhao, Zhuanglin Shen, Wei Li, Guiyun Zhao, Jiahai Zhou*, Yi-Ling Du* (2023) A conserved enzymatic cascade for bacterial azoxy biosynthesis. Journal of the American Chemical Society, doi: 10.1021/jacs.3c12018. Guiyun Zhao, Wei Peng, Kaihui Song, Jingkun Shi, Xingyu Lu, Binju Wang* & Yi-Ling Du* (2021) Molecular basis of enzymatic nitrogen-nitrogen formation by a family of zinc-binding cupin enzymes. Nature Communication, 12, 7205, doi: 10.1038/s41467-021-27523-x . Xinjie Shi, Liming Huang, Kaihui Song, Guiyun Zhao, Yu Liu, Longxian Lv, Yi-Ling Du* (2021) Enzymatic Tailoring in Luzopeptin Biosynthesis Involves Cytochrome P450-Mediated Carbon-Nitrogen Bond Desaturation for Hydrazone Formation. Angewandte Chemie International Edition, doi: 10.1002/anie.202105312. Guiyun Zhao, Yuan-Yang Guo, Shunyun Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du*(2020) Nitric oxide as a source for bacterial triazole biosynthesis. Nature Communications, doi: 10.1038/s41467-020-15420-8. Yi-Ling Du*, Melanie A Higgins, Guiyun Zhao, Katherine S Ryan* (2019) Convergent biosynthetic transformations to a bacterial specialized metabolite. Nature Chemical Biology,15, 1043–1048 Yi-Ling Du, Hai-Yan He, Melanie A Higgins, Katherine S Ryan* (2017) A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nature Chemical Biology, 13(8): 836-838. Kaihui Song, Wei Li, Zhijie Zhao, Hu Li, Yu Liu, Guiyun Zhao, Hai-Yan He, Yi-Ling Du* (2023) Heterologous Reconstitution of Toxoflavin Biosynthesis Reveals Key Pathway Intermediates and a Cofactor-Independent Oxidase. Organic Letters, doi:10.1021/acs.orglett.3c01000. Zhijie Zhao, Guiyun Zhao, Yi Chai, Wei Li, Kaihui Song, Wenbin Zhao, Hairong Li, Miaolian Wu, Zhan Zhou*, Yi-Ling Du* (2023) Targeted genome mining for microbial antitumor agents acting through DNA intercalation. Synthetic and Systems Biotechnology, 8(3): 520–526. Guiyun Zhao Shunyu Yao Kristina W Rothchild Tengfei Liu Yu Liu Jiazhang Lian Hai-Yan He Katherine S Ryan, Yi-Ling Du* (2019) The biosynthetic gene cluster of the C‐ nucleoside antibiotic pyrazomycin with a rare pyrazole moiety, Chembiochem, doi:10.1002/cbic.201900449 Yi-Ling Du*, Katherine S Ryan* (2018) Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products. Natural Product Reports, 36, 430-457 Hai-Yan He, Alyssa C. Henderson, Yi-Ling Du, Katherine S. Ryan* (2019) Two-Enzyme Pathway Links l-Arginine to Nitric Oxide in N-Nitroso Biosynthesis. J. Am. Chem. Soc. 2019, 141(9):4026-4033 Yuan-Yang Guo, Zhen-Hua Li, Tian-Yu Xia, Yi-Ling Du, Xu-Ming Mao* & Yong-Quan Li*. (2019) Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis. Nature Communications, 4420 (2019) Lian-Hua Xu*, Yi-Ling Du* (2018) Rational and semi-rational engineering of cytochrome P450s for biotechnological applications. Synthetic and Systems Biotechnology, 3(4): 283–290