Brook, Mike - McMaster University - Department of Chemistry & Chemical Biology

个人简介

Mike Brook is a Professor of Chemistry and Chemical Biology. He received a B.Sc. with Honours from the University of Toronto in 1978, and a Ph.D. from McGill University in 1983 where he worked in the group of Tak Hang (Bill) Chan, and then did a postdoc at the Swiss Federal Institute of Technology in Zurich from 1984 to 1985 with Dieter Seebach. Brook is an expert in silicon, silica and silicone chemistry. He wrote the solely authored book Silicon in Organic, Organometallic and Polymer Chemistry (Wiley) in 2000 and was Americas editor of Silicon Chemistry. His main interests revolve around the application of silicon chemistry to materials science, particularly in interfacial control for biomedical applications. Currently, his research has three main axes: manipulation of silicone elastomers for improved biocompatibility (including drug delivery and surface properties), developing silicone surfactants to structure growth of metal nanofoams and silicone hydrogels, and developing synthetic strategies to create high molecular weight silicones with explicit structural control. Brook has served on Expert Advisory Panels on Breast Implants for the Therapeutic Products Directorate of the Health Canada (the approximate equivalent of the Food and Drug Administration FDA in the United States) in 2002 and 2005. He was also an external expert reviewer for select screening level risk assessments for Environment Canada in 2010. Brook also consults extensively. Honors and Awards Prof. Brook has been recognized with honours and awards for both his research and teaching accomplishments. He was nominated 7 times by the McMaster student union for a teaching award and won twice, and was winner of the President's Award for Instruction. He has been a visiting professor at 6 different universities (National University of Ireland, Galway, Ireland; Adelaide, Australia; Lyon, France; Bordeaux, France; Toulouse, France and Amsterdam, The Netherlands). He has been honoured to receive the following awards: CSIRO Distinguished Visiting Scientist, Melbourne Australia (2011); ETS Walton Visiting Research Professor (Science Foundation Ireland)(2007); Killam Fellowship (Canada Council of the Arts)(2003-2004); The Synergy Award, Conference Board of Canada, NSERC (with Mark R. McDermott and Connaught Laboratories, now Sanofi-aventis)(1996); Dutch National Science Foundation Foreign Researchers Award (NWO Bezoekersbeurs)(1992-93).

研究领域

Silicon-derived compounds, particularly silicones and silica, are known for their surface activity. The research projects in our lab share the common mission of bringing concepts from synthetic chemistry into biological systems that are in need of new experimental approaches. Much of our current interest is concentrated on developing molecules that can control interfaces, particularly silicones, which are broadly used in a variety of biomaterial applications including wound dressings, and implantable devices. Although various members of the group have expertise in biology, and in colloid and surface science, the heart of the group concentrates on synthetic chemistry.

近期论文

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F Ye, L.; Pelton, R.; Brook, M. A.; Filipe, C.; Wang, H.; Brovko, L.; Griffiths, M. Targeted Disinfection of E. Coli via Bioconjugation to Photoreactive TiO2, Bioconjugate Chemistry, accepted Feb. 20, 2013. F Pelton, R.; Cui, Y.; Zhang, D.; Chen, Y.; Haines, A.; Thompson, K. L.; Armes, S. P.; Brook, M.; Ketelson, H. A Facile Phenylboronate Modification of Silica by a Silaneboronate, Langmuir 2013, 29, 594-598, DOI: 10.1021/la3040837. C Brook, M. A.; Dodge, L.; Chen, Y.; Gonzaga, F.; Amarne, H. Sugar complexation to silicone-boronic acids, Chem. Commun., 2013, 49, 1392-1394. DOI:10.1039/C2CC37438B F F. Gonzaga, L. Sadowski, T. Rambarran, J. Grande, A. Adronov and M. A. Brook, Highly efficient divergent synthesis of dendrimers via metal-free "click" chemistry, J. Polym. Chem. A.; Polym. Sci., 2013, 51, 1272-1277 DOI: 10.1002/POLA.26511 F Talena Rambarran, Ferdinand Gonzaga and Michael A. Brook, Multifuntional Amphiphilic Siloxane Architectures Using Sequential, Metal-Free Click Ligations, J. Polym. Chem. A.; Polym. Sci. 2013, 51, 855-864. DOI: 10.1002/pola.26642. F Amanda S. Fawcett, John B. Grande and Michael A. Brook Rapid, metal-free room temperature vulcanization produces silicone elastomers, J. Polym. Chem. A: Polym. Sci. 2013, 51, 644-652. DOI:10.1002/pola.26414. F So, H.; Fawcett, A.; Sheardown, H.; Brook, M. A. Surface-active copolymer formation stabilizes PEG droplets and bubbles in silicone foams, J. Colloid Interface Sci. 2013, 390, 121-128. DOI: 10.1016/j.jcis.2012.09.017. F Michael A. Brook and Mustafa Mohamed, Lewis acid-mediated addition of amino acid-substituted a-allylsilanes to aromatic acetals, Helv. Chim. Acta, 2012, 95, 2660-2671. DOI: 10.1002/hlca.201200533 F Vanderkooy, A.; Brook, M. A. Polyvinylpyrrolidone Molecular Weight Controls Silica Shell Thickness on Au Nanoparticles with Diglycerylsilane as Precursor, ACS Applied Materials and Interfaces, 2012, 4, 3980–3986, DOI: 10.1021/am300809q F Andrea Weeks, David Morrison, Johan Alauzun, Michael A. Brook, Lyndon Jones, Heather Sheardown, Photocrosslinkable HA as an Internal Wetting Agent in Model Conventional and Silicone Hydrogel Contact Lenses, J. Biomed. Mater. Res. Part A, 2012, 100A, 1972-1982, DOI: 10.1002/mabi.201100001. F Farrugia, B. L.; Keddie, D. J.; George, G. A.; Lynam, E. C.; Brook, M. A.; Upton, Z.; Dargaville T. R. An Investigation into the Effect of Amphiphilic Siloxane Oliogmers on Dermal FIbroblasts, J. Biomed. Mater. Res. Part A, 2012, 100A, 1919-1927. F Grande, J. B.; Fawcett, A. S.; McLaughlin, A. J.; Gonzaga, F.; Bender, T. P.; Brook, M. A. Anhydrous Formation of Foamed Silicone Elastomers using the Piers-Rubinsztajn Reaction, Polymer 2012, 53, 3135-3142 DOI: 10.1016/m.polymer.2012.05.033. F Lu, C.; Mikhail, A. S.; Wang, X.; Brook, M. A.; Allen, C. Hydrogels Containing Core Cross-Linked Block Co-Polymer Micelles, J. Biomater. Sci., Polym. Ed. 2012, 23, 1069-1090 DOI: 10.1163/092050611X575414 F Rambarran, T.; Gonzaga, F.; Brook, M. A. Generic, metal-free crosslinking and modification of silicone elastomers using click ligation, Macromolecules, 2012, 45, 2276-2285. F Kamino, B. A.; Mills, B.; Reali, C.; Gretton, M. J.; Brook, M. A.; Bender, T. P. Liquid Triarylamines: The Scope and Limitations of Piers-Rubinsztajn Conditions for Obtaining Triarylamine-Siloxane Hybrid Materials, J. Org. Chem. 2012, 77, 1663-`1674. F Vinodh Rajendra, Ferdinand Gonzaga and Michael A. Brook, Nearly Monodisperse Silica Microparticles Form in Silicone (Pre)elastomer Mixtures, Langmuir, 2012, 28, 1470–1477, DOI: 10.1021/la2035505. F Michael J. Gretton, Brett A. Kamino, Michael A. Brook and Timothy P. Bender, The Use of Piers-Rubinsztajn Conditions for the Placement of Triarylamines Pendant to Silicones, Macromolecules 2012, 45, 723−728.jj dx.doi.org/10.1021/ma202041u. F. Ferdinand Gonzaga, John B. Grande and Michael A. Brook, Morphology-controlled synthesis of poly(oxyethylene) silicone- or alkyl-silicone surfactants with explicit, atomically-defined branched hydrophobic tails, Chemistry – A European Journal, 2012, 18, 1536–1541, DOI: 10.1002/chem.201103093. F Michael A. Brook, Shigui Zhao, Lihua Liu and Yang Chen, Surface Etching of Silicone Elastomers by Depolymerization, Can. J. Chem. 2012, 90, 153-160, 10.1139/v11-145. Special issue for Bill Chan. C Daniel J. Keddie, John B. Grande, Ferdinand Gonzaga, Michael A. Brook and Tim R. Dargaville, Amphiphilic Silicone Architectures via Anaerobic Thiol-Ene Chemistry, Org. Lett., 2011, 13, 6006-6009.