陈烨 - 浙江大学

个人简介

陈烨，理学博士，现任浙江大学特聘研究员、博士生导师。长期从事人类重要疾病致病机制及转化应用的相关研究，主要研究方向包括人类遗传学、干细胞分化、细胞与微环境（microenvironment）的相互调控、以及实验动物疾病模型建立等。已在Journal of Clinical Investigation、BLOOD、Clinical Cancer Research等国际权威学术期刊发表研究论文20多篇。教育和工作经历: 2000/09 - 2004/07 浙江大学生物科学专业学士 2004/09 - 2009/07 浙江大学细胞生物学专业博士 2009/09 - 2013/06 美国 MD. Anderson Cancer Center, Department of Stem Cell Transplantation & Cellular Therapy, Department of Leukemia 博士后 2013/07 - 2015/03 浙江大学生命科学学院特聘研究员 2015/03 - 迄今浙江大学医学院/生命科学学院特聘研究员

研究领域

（1）干细胞定向分化（2）细胞与微环境的相互作用（3）肿瘤细胞耐药性及其逆转途径（4）母系遗传性非综合症型耳聋发病机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Yu J, Zheng J, Zhao X, Liu J, Mao Z, Ling Y, Chen D, Chen C, Hui L, Cui L, Chen Y, Jiang P, Guan MX. Aminoglycoside Stress Together with the 12S rRNA 1494C>T Mutation Leads to Mitophagy. PLoS One. 2014 Dec 4;9(12):e114650. 2. Zhang W, Gao C, Konopleva M, Chen Y, et al. Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies. Clin Cancer Res. 2014;20(9):2363-74. 3. Jacamo R, Chen Y, Wang Z, et al. Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kB mediates chemoresistance. Blood. 2014;20(9):2363-74. 4. Lu H, Kojima K, Battula VL, Korchin B, Shi Y, Chen Y, et al. Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth. Ann Hematol. 2014;93(3):485-92. 5. Battula VL, Chen Y, Cabreira Mda G, et al. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. Blood. 2013;122(3):357-66. 6. Chen Y, Jacamo R, Konopleva M, et al. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest. 2013;123(6):2395-407. 7. Ling XY, Spaeth E, Chen Y, et al. The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo. PLOS ONE.2013;8(3):e58426. 8. Chen Y, Jacamo R, Shi YX, et al. Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment. Blood. 2012;119(21):4971-80. 9. Kojima K, McQueen T, Chen Y, et al. p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12. Blood. 2011;118(16):4431-9. 10. Chen Y, Xiang LX, Shao JZ, et al. Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver. J Cell Mol Med. 2010;14(6B):1494-508.