个人简介
1992.9-1995.6 原浙江医科大学临床医学系就读;
1998.9-2001.6 浙江大学医学院攻读免疫学硕士学位;
2001.9-2004.6 浙江大学医学院攻读肿瘤学博士学位;
2004.8-2007.12 浙江大学医学院免疫学系任讲师;
2007.12-至今 浙江大学医学院免疫学系任副教授;
2009.10-至今 美国Duke大学做博士后工作
近期论文
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1. Chen W, Li N, Chen T, Han Y, Li C, Wang Y, He W, Zhang L, Wan T, Cao X. The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway. J Biol Chem. 2005, 280(49):40985-40995. (影响因子: 5.85)
2. Li N, Zheng Y, Chen W, Wang C, Liu X, He W, Xu H, Cao X. Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res. 2007 Dec 1;67(23):11176-11185. (共同第一作者,影响因子: 7.656)
3. Li H, Xie Q, Wang H, Shao C, Chen W. Intramuscular delivery of mIL-12 gene reduces the expression of CD44/CD49d on pulmonary leucocytes and inhibits ovalbumin-induced airway hyperreactivity. Inflamm Res. 2008 Jan;57(1):11-17. (通讯作者,影响因子: 1.485)
4. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X. Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood. 2004, 103(2):413-421. (影响因子: 10.13)
5. Li C, Liu Q, Li N, Chen W, Wang L, Wang Y, Yu Y, Cao X. EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. J Mol Med. 2008 Apr;86(4):471-484. (影响因子: 5.157)
6. He W, Liu Q, Wang L, Chen W, Li N, Cao X. TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol. 2007 Apr;44(11):2850-2859. (影响因子: 4.768)