Berti, Paul - McMaster University - Department of Chemistry & Chemical Biology

研究领域

Our research encompasses two main areas - enzymes, and molecular imaging probes. You can find out more about our work under the Research tab. Research Transition State Analysis Enzyme Mechanisms and Inhibition Imaging Infections

近期论文

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Lou, M., Gilpin, M. E., Burger, S. K., Malik, A. M., Gawuga, V., Popovic, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134:12947-12957 Transition State Analysis of Acid-Catalyzed Hydrolysis of an Enol Ether, Enolpyruvylshikimate 3-Phosphate (EPSP) (link) Lou, M., Burger, S. K., Gilpin, M. E., Gawuga, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134: 12958-12969 Transition State Analysis of Enolpyruvylshikimate 3-Phosphate Synthase (AroA)-Catalyzed EPSP Hydrolysis (link) Rob, T., Liuni, P., Gill, P. K., Zhu, S., Balachandran, N., Berti, P. J. & Wilson, D. J. (2012) Anal. Chem. 84: 3771-3779 Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry (link) Jiang, S., Gilpin, M. E., Attia, M., Ting, Y.-L. & Berti, P. J. (2011) Biochemistry 50: 2205-2212 Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp (link) Jackson, S. G., Zhang, F., Chindemi, P., Junop, M. S. & Berti, P. J. (2009) Biochemistry 48:11715-11723 Evidence for Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions (link) Berti, P. J. & Chindemi, P. (2009) Biochemistry 48:3699-3707 Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis (link) McCann, J. A. B. & Berti, P. J. (2008) J. Am. Chem. Soc. 130:5789-5797 Transition State Analysis of the DNA Repair Enzyme MutY (link) McCann, J. A. B. & Berti, P. J. (2007) J. Am. Chem. Soc. 129:7055-7064 Transition State Analysis of Acid-catalyzed dAMP Hydrolysis (link) Clark, M. E. & Berti, P. J. (2007) Biochemistry 46:1933-1940 Enolpyruvyl Activation by Enolpyruvyl Shikimate 3-Phosphate Synthase (link) Zhang, F. & Berti, P. J. (2006) Biochemistry 45:6027-6037 Phosphate Analogues as Probes of the Catalytic Mechanisms of MurA and AroA, Two Carboxyvinyl Transferases (link) Loncke, P. G. & Berti, P. J. (2006) J. Am. Chem. Soc. 128:6132-6140 Implications of Protonation and Substituent Effects for C-O and O-P Bond Cleavage in Phosphate Monoesters (link) Berti, P. J. & McCann, J. A. B. (2006) Chem. Rev. 106:506-555 Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer (link) Mizyed, S., Oddone, A., Byczynski, B., Hughes, D. W., & Berti, P. J. (2005) Biochemistry 44:4011-4017 UDP-N-acetylmuramic acid (UDP-MurNAc) is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase) (link) Lee, J. K., Bain, A. D. & Berti, P. J. (2004) J. Am. Chem. Soc. 126:3769-3776 Probing the Transition States of Four Glucoside Hydrolyses with 13C Kinetic Isotope Effects Measured at Natural Abundance by NMR Spectroscopy. (link) Byczynski, B., Mizyed, S. & Berti, P. J. (2003) J. Am. Chem. Soc. 125:12541-12550 Non-enzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Control the Rate and Fate of Breakdown. (link) McCann, J. A. B. & Berti, P. J. (2003) J. Biol. Chem. 278:29587-29592 Adenine Release is Fast in MutY-Catalyzed Hydrolysis of G:A and 8-oxo-G:A DNA Mismatches (link) Mizyed, S., Wright, J. E. I., Byczynski, B. & Berti, P. J. (2003) Biochemistry 42:6986-6995 Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis (link) Berti, P. J., & Tanaka, K. S. E. (2002) Adv. Phys. Org. Chem. 37:239-314 Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer (link) Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122:6527-6534 Transition State Analysis for Depurination of DNA by Ricin A-Chain Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122:1609-1617 Ricin A-Chain: Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA