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个人简介

工作经历 1984.8-1985.10 助教 浙江大学医学院 1985.10-1990.8 住院医师 浙江大学医学院附属第一医院 1992-1993 访问学者 德国吕贝克大学 1990.8-1995.10 主治医师 浙江大学医学院附属第一医院 1995.8-2000.10 副主任医师 副教授 浙江大学医学院附属第一医院 1999-2000 访问学者 德国洪堡大学 2000- 主任医师 教授 浙江大学医学院附属第一医院 2004.9-11 访问学者 德国图宾根大学 2008.3-9 访问学者 美国M.D.Andeson癌症中心

研究领域

1、恶性血液系统疾病(主要以MM、AL、MDS和NHL为主)的临床和基础研究。 2、化疗药物作用机理、信号传导和基因调控研究。 3、造血干细胞移植临床和基础研究。

近期论文

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1. He DH, Chen TY, Yang MJ, Zhu XH, Wang C, Cao X, Cai Z. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. J Mol Med. 2011; 89 (2):137-150. 2. Bao HY, Lu PL, Li Y, Wang LJ, Li HY, He DH, Yang Y, Zhao Y, Yang L, Wang M, Yi Q, Cai Z. Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther. 2011; 11(1):58-67. 3. Luo Y, Zhao Y, Tan Y, Shi J, Han X, Zheng Y, Li L, He J, Xie W, Ye X, Cai Z, Lin M, Huang H. Imatinib combined with myeloablative allogeneic hematopoietic stem cell transplantation for advanced phases of chronic myeloid leukemia. Leuk Res. 2011 Feb 25. [Epub ahead of print] 4.Qian Z, Zhang L, Cai Z, Sun L, Wang H, Yi Q, Wang M. Lenalidomide synergizes with dexamethasone to induce growth arrest and apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leuk Res. 2010 Nov 1. [Epub ahead of print] 5. Zheng W, Guan M, Zhu L, Cai Z, Chung V, Huang H, Yen Y. Bortezomib therapeutic effect is associated with expression and mutation of FGFR3 in human lymphoma cells. Anticancer Res. 2010 Jun;30(6):1921-30. 6. Xiao H, Cao W, Lai X, Luo Y, Shi J, Tan Y, He J, Xie W, Meng X, Zheng W, Zheng G, Han X, Jin L, Zhang L, Wang Y, Yu X, Cai Z, Lin M, Ye X, Huang H. Immunosuppressive cytokine gene polymorphisms and outcome after related and unrelated hematopoietic cell transplantation in Chinese population. Biol Blood Marrow Transplant. 2010 May 7. [Epub ahead of print] 7. Zheng Y, Cai Z, Wang S, Zhang X, Qian J, Hong S, Li H, Wang M, Yang J, Yi Q. Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood. 2009,114(17): 3625-3628. 8. Zheng W, Wei G, Ye X, He J, Li L, Wu W, Shi J, Zhang J, Huang W, Xie W, Luo Y, Xue X, Lin M, Huang H, Cai Z. Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: a Chinese Experience. Leuk Rec. 2009; 33(12) :1615-1618. 9. Shi JM, Cai Z, Huang H, Ye XJ, He JS, Xie WZ, Zhang J, Zhou XY, Luo Y, Lin Y, Li L, Zheng WY, Wei GQ, Lin MF. Role of CT-guided percutaneous lung biopsy in diagnosis of pulmonary fungal infection in patients with hematologic diseases. Int J Hematol. 2009; 89(5):624-627. 10.Wang M, Sun L, Qian J, Han X, Zhang L, Lin P, Cai Z, Yi Q. Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy. Leukemia. 2009; 23:1320-1328. 11. Yao M, Liu X, Li D, Chen T, Cai Z, Cao X. Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol. 2009; 183(3):1751-1758. 12. Zhang L, Qian Z, Cai Z, Sun L, Wang H, Bartlett JB, Yi Q, Wang M. Synergistic antitumor effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivo. Am J Hematol. 2009; 84(9):553-559. 13. Qiu L, He J, Ye X, Xie W, Shi J, Zheng W, Sun J, Zhu X, Cai Z, Huang H, Lin M. Invasive pulmonary fungal infection accompanied by severe hemoptysis in patients with hematologic diseases: a report of nine cases. Int J Hematol. 2009 ,90(1):108-112. 14. Zhao Y, Liu L, Wang Y, Wu G, Lai X, Cao W, Luo Y, Tan Y, Shi J, Xie W, Ye X, Cai Z, Lin M, Huang H. Efficacy and prognosis of chronic myeloid leukemia treated with imatinib mesylate in a Chinese population. Int J Hematol. 2009 ,89(4): 445 -451. 15. Bao HY, Wang LJ, Yang Y, Cai Z. TLR4 signals are involved in multiple myeloma cell proliferation and apoptosis. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Sep;38(5):465-9. Chinese. 16. Hu J, He DH, XUE XK, Gao L, Wu WJ, Han XY, Cai Z. Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplastic reticulum stress pathway. Leukemia &Lymphoma. 2007; 48(5):964-977. 17. Wang Y Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood. 2007; 110(3): 962-971.

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