李新 - 浙江大学

个人简介

现任浙江大学药学院副教授，博士生导师，入选国家级青年人才支持计划。于中国科学院上海药物研究所获博士学位（药物化学专业）；曾分别于浙江大学药学院、哈佛大学化学系（EJ Corey实验室）、耶鲁大学化学系（Alanna Schepartz实验室）从事博士后或访问研究。

研究领域

胞内生物分子及生化事件处于动态变化中。实时监测相关分子及事件在病理损伤中的时空变化规律，有助于了解疾病发生的分子机制，发现新型疾病诊疗靶标。本实验室主要从事实时成像分子探针研究工作。通过综合利用药物设计原理、分子化学反应性、及光物理原理，发展高特异性及高成像对比度光学探针，在多种生命维度实时成像靶分子的时空变化规律，助力新疾病诊疗靶标的发现及新药物筛选模型的开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

An inherently kidney-targeting near-infrared fluorophore based probe for early detection of acute kidney injury Biosens. Bioelectron., 2021, 172, 112756. Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells CCS Chemistry, 2021, 3, 116–128. Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study ACS Appl. Bio Mater. 2021, 4, 2058−2065. Physicochemical-property guided design of a highly sensitive probe to image nitrosative stress in the pathology of stroke Chemical Science, 2020, 11, 281-289. Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection Analytical Chemistry ,2020, 92, 699-702. Sequentially Activated Probe Design Strategy for Analyzing Metabolite Crosstalk in a Biochemical Cascade Analytical Chemistry , 2020, 92, 1, 1409-1415. A fluorogenic probe for tracking GSH flux in developing neurons Chemical Communications, 2020, 56, 515. Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system Journal of Pharmaceutical Analysis ,10 (2020) 466e472. Microenvironment‑triggered dual‑activation of a photosensitizer‑fluorophore conjugate for tumor specific imaging and photodynamic therapy Scientific Reports, 2020, 10:12127. Visualizing Autophagic Flux During Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe Theranostics, 2019, 9(19): 5672-5680. State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research Acta Pharmacologica Sinica, 2019, 40, 717-723. GSH Activated Biotin-tagged Near-Infrared Probe for Efficient Cancer Imaging Theranostics, 2019, 9(12), 3515-3525. Rational design of the benzothiazole-based fluorescent scaffold for tunable emission Tetrahedron Letters, 2019, 60 (15), 1060-1065. Bis-reaction-trigger as a strategy to improve the selectivity of fluorescent probes Chemical Communications, 2018, 54, 8170-8173. A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells Chemical Communications, 2018, 54, 1857-1860 Conformational restraint as a strategy for navigating towards lysosomes Chemical Communications, 2018, 54, 12010-12013 An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance Chemical Science, 2017, 8, 8012-8018. A H2O2-Responsive Theranostic Probe for Endothelial Injury Imaging and Protection Theranostics, 2017, 7, 3803-3813. A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues Theranostics, 2017, 7, 2305-2313. A Fluorogenic Probe for Imaging Protein S-nitrosylation in Live Cells Biosensors & Bioelectronics, 2017, 94, 162.