周慧 - 浙江大学

个人简介

教育背景： 1992-1996 四川联合大学化学系，理学学士 1999-2005 浙江大学化学系，理学博士研究工作经历： 1996-1999 江西中医学院药学系，助教 2005-2007 浙江大学药学院，博士后 2007-2011 浙江农林大学林业与生物技术学院，副研究员 2011-2013 浙江大学药学院，副研究员 2013-至今浙江大学药学院，副教授

研究领域

质谱分析、药物分析临床前药代动力学研究药物代谢与药物转运

近期论文

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[1] Siyuan Sun, Kai Wang, Hongmei Lei, Liping Li, Meijuan Tu, Su Zeng,Hui Zhou*, Huidi Jiang*. Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry, 2014; 49:1–6. [2] Lushan Yu, Qi Shen, Quan Zhou, Huidi Jiang, Huichang Bi, Min Huang, Hui Zhou*, Su Zeng. In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. J Ethnopharmacol, 2013; 150: 485-491. [3] Ye Tian, Sainan Qian, Yan Jiang, Qi Shen, Jiang Zheng, Hui Zhou*, Su Zeng*. The interaction between human breast cancer resistance protein(BCRP) and five bisbenzylisoquinoline alkaloids. Int J Pharmaceut, 2013; 311: 225-230. [4] Meijuan Tu, Siyuan Sun, Kai Wang, Xueying Peng, Ruihan Wang, Liping Li, Su Zeng, Hui Zhou*, Huidi Jiang*. Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity. Toxicology, 2013; 311:225-230. [5] Meng Chen, Yan Lou, Yaodong Wu, Zhaoke Meng, Liping Li, Lushan Yu, Su Zeng , Hui Zhou*, Huidi Jiang*. Characterization of in vivo and in vitro metabolites of furanodiene in rats by high performance liquid chromatography – electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. J Pharm Biomed Anal, 2013; 86:161-168. [6] Zhong-Jian Chen, Yan-Qing Dai, Si-Si Kong, Fei-Feng Song, Li-Ping Li, Jian-Feng Ye, Ru-Wei Wang, Su Zeng, Hui Zhou* and Hui-Di Jiang*. Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation. Mol Nutr Food Res, 2013; 57(5):877-885. [7] Si-Yuan Sun, Yu-Qing Wang, Liping Li, Lu Wang, Su Zeng, Hui Zhou*, Hui-Di Jiang*. Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes. Chirality, 2013; 25:43-47. [8] Hui Zhou, Junling Liang, Da Lv, Yinfei Hu, Yan Zhu, Jinping Si*, Shihua Wu*. Characterization of phenolics of Sarcandra glabra by non-targeted high-performance liquid chromatography fingerprinting and following targeted electrospray ionisation tandem mass spectrometry /time-of-flight mass spectrometry analyses. Food Chem,2013,138(4):2390-2398. [9] Hui Zhou, Liping Li, Huidi Jiang, Su Zeng*. Identification of three new N-demethylated and o-demethyled bisbenzylisoquinoline alkaloid metabolites of isoliensinine from dog hepatic microsomes. Molecules, 2012;17(10):11712-11720. [10] Hui Zhou, Huidi Jiang, Tongwei Yao, Su Zeng*. Fragmentation study on phenolic alkaloids neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. Rapid Commun Mass Spectrom. 2007; 21(13): 2120-8.