盛荣 - 浙江大学

个人简介

一. 学习经历 1990.9－1994.7 杭州大学化学系有机化学专业本科 1994.9－1997.8 中科院上海应用物理研究所硕士 2001.2－2005.6 浙江大学药学院博士二. 工作经历： 1997.8－1999.12 浙江医科大学药学院药物化学研究室助教 2000.1－2006.12 浙江大学药学院药物化学研究室讲师 2007.1－至今浙江大学药学院药物所副教授 2009.6－2010.11美国密西根大学医学院博士后

研究领域

靶向H3受体、淀粉样蛋白的新型抗早老性痴呆药物设计与合成；小分子HIF-1抑制剂的设计与结构优化研究。

近期论文

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1. Li Tang , Liying Zhao, Lingjuan Hong, Fenyan Yang, Rong Sheng*, Jianzhong Chen, Ying Shi, Naimin Zhou, Yongzhou Hu. Design and synthesis of novel 3-substituted-indole derivatives as selective H3 receptor antagonists and potent free radical scavengers. Bioorg. Med. Chem. 2013, 5936–5944 2. Sheng R, Sun H, Liu L, Lu J, McEachern D, Wang G, Wen J, Min P, Du Z, Lu H, Kang S, Guo M, Yang D, Wang S. A Potent Bivalent Smac Mimetic (SM-1200) Achieving Rapid, Complete, and Durable Tumor Regression in Mice. J Med Chem. 2013, 56, 10, 3969-3979 3. Shihao Shangguan, Fei Wang, Yong Liao, Haiping Yu, Jia Li, Wenhai Huang, Haihong Hu, Lushan Yu, Yongzhou Hu, Rong Sheng*. Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenyl-benzamide Derivatives as BACE-1 Inhibitors. Molecules 2013, 18, 3577-3594 4. Ying Shi, Rong Sheng, Tingting Zhong, Yu Xu, Xiaopan Chen, Dong Yang, Yi Sun, Fenyan Yang, Yongzhou Hu, Naiming Zhou. Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor. Plos One, 2012, 8, e42185 5. Rong sheng, Jiangwei Zhu, Yongzhou Hu, Mild and Efficient Winterfeldt Oxidation of 1,2,3,4-Tetrahydro- γ-carbolines for the Synthesis of Dihydropyrrolo[3.2-b]-Quinolones and Pyrrolo[3.2-b]Quinolones, Molecules 2012, 17, 1177-1190 6. Qing Xia, Ling Zhang, Jun Zhang, Rong Sheng, Bo Yang, Qiaojun He, Yongzhou Hu Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives. Euro. J. Med. Chem, 2011, 46, 919-926 7. Huang, WH, Sheng, R, Hu, YZ. Progress in the Development of Nonpeptidomimetic BACE 1 Inhibitors for Alzheimer's Disease. Curr. Med Chem. 2009, 16, 1806-1820 8. Rong Sheng, Xiao Lin, Jing Zhang, Kim Sun Chol, Wenhai Huang, Bo Yang, Qiaojun He, Yongzhou Hu, Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors, Bioorg. Med. Chem.2009, 18, 6692-6698. 9. Liao Y, Huang WH, Hu CQ, Hu YZ, Sheng R*. Dehydrogenation Synthesis of 1,3-Diphenylpyrazoles，Chin. J. Organ. Chem.,2009, 29, 784-787 10. Rong Sheng; Li Shen; You-Qin Chen; Yong-Zhou Hu，Convenient and Efficient Synthesis of 1-Oxo-1,2,3,4-tetrahydrocarbazoles via Fischer Indole Synthesis.Syn. Commun.,2009, 39,6, 1120 – 1127