张翔南 - 浙江大学

个人简介

一、教育经历： 2005.6 毕业于浙江大学药学院药学专业本科 2007.10-2008.10 教育部公派留学德国基尔大学人类健康研究所博士联合培养 2010.6 博士毕业于浙江大学药理毒理与生化药学研究所二、工作经历： 2010.9-2012.12 浙江大学医学神经生物学研究所博士后 2012.12-2013.12浙江大学药理毒理与生化药学研究所讲师 2013.12-至今浙江大学药理毒理与生化药学研究所副教授

研究领域

缺血性脑卒中的神经药理学。尤其关注：缺血性脑损伤过程中自噬的发生机制及其相关药物调控靶点的发现

近期论文

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1. Xiangnan Zhang, Yang Yuan, Lei Jiang, Jingying Zhang, Jieqiong Gao, Zhe Shen, Yanrong Zheng, Tian Deng, Haijing Yan, Wenlu Li, Wei-Wei Hou, Jianxin Lu, Yao Shen, Haibing Dai, Wei-Wei Hu, Zhuohua Zhang and Zhong Chen*: Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. (2014) Oct 1;10(10):1801-13 (IF=11.42) 2. Xiangnan Zhang, Haijing Yan, Yang Yuan, Jieqiong Gao, Zhe Shen, Yun Cheng, Yao Shen, Rong-Rong Wang, Xiaofen Wang, Wei-Wei Hu, Guanghui Wang, Zhong Chen*: Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondria clearance. Autophagy. (2013) Sep 1;9(9):1321-33 (IF=12.04) 3. Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lv, Hiroshi Ohtsu, Feng Han, Guanghui Wang, Zhong Chen*. Histamine H3 Receptors Aggravate Cerebral Ischemic Injury by Histamine -independent Mechanisms. Nauture Communications (2014) Feb 25;5:3334. doi: 10.1038/ncomms4334. (Co-first author, IF=10.75) 4. Zhe Shen, Lei Jiang, Yang Yuan, Tian Deng, Yan-Rong Zheng, Wen-Lu Li, Jia-Ying Wu, Jian-Qing Gao, Wei-Wei-Hu, Xiang-Nan Zhang* (Co-coresponding author), Zhong Chen*: Inhibition of G-Protein-Coupled Receptor 81 (GPR81) ProtectsAgainst Ischemic Brain Injury. CNS Neuroscience & Therpeutics. (2015) ,Mar;21(3):271-9. doi: 10.1111/cns.12362. 5. Xiangnan Zhang, Jiaying Wu, Yuan Dou, Binbin Xia, Weibo Rong, Gerald Rimbach, Yijia Lou*: Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. Eur J Pharmcol. (2012) Mar 15;679(1-3):51-9.