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个人简介

香港中文大学博士,现任浙江大学药学院副教授、博导。2017中国药学会-优秀青年药剂学工作者、加州大学伯克利分校访问学者。带领小组研究生以第一和通讯作者在Science Advances、Advanced Functional Materials、Jounrnal of Controlled Release 等知名期刊发表SCI论文40余篇, 担任《现代中药制剂设计》副主编、药剂学(案例版)、《中药经皮给药制剂技术》编委。以第一发明人授权国家发明专利13项,并获得转化。长期致力于结合生物材料、纳米科技与先进制造技术构建智能递释系统用于核酸、蛋白药物、中药活性成分的递送,并应用于皮肤、神经再生与肿瘤治疗,取得了系列创新性研究成果,形成了以经皮与外用纳米制剂、干细胞制剂、护肤品为特色的研制体系。以负责人身份完成国家自然科学基金、国家重点研发计划子课题,省部级及企业合作项目多项。以骨干成员参与完成国家自然科学基金、浙江省自然基金重点项目、企业重大横向等海内外研发计划十余项。现为国际控释协会仿生制剂专委会学术委员、世界中医药学会联合会经皮给药专业委员会副秘书长、世中联保健品专业委员会常务理事、基因治疗SCI核心期刊Current Gene Therapy客座主编、《中草药》(中英双刊)、《中医科学杂志》、《中国现代应用药学杂志》青年编委、四十余本SCI核心期刊审稿人。2019 Elsevier杂志社(Biomaterials, International Journal of Pharmaceutics杂志)优秀审稿人。长期担任多家制药、医疗器械、化妆品企业技术顾问。

研究领域

核酸/蛋白递释技术 干细胞与组织工程 经皮与外用制剂 中药新剂型

近期论文

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Li-Hua Peng*#, Mao-Ze Wang#, Yang Chu#, Lei Zhang#, Jie Niu#, Hai-Tao Shao, Tie-Jun Yuan, Zhi-Hong Jiang, Jian-Qing Gao*, Xing-Hai Ning*, Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL programmed therapy against melanoma, Science Advance (2020; 6 : eaba2735). Li-Hua Peng*#, Yan-Fen Huang#, Xue-Han Xu#, Xiao-Li Zhao, Bo Zhao, Sheng-Ying Cai, Ming-Jun Xie, Mao-Ze Wang, Tie-Jun Yuan, Yong He*, Zhen Xu, Jian-Qing Gao*, Chao Gao* Self-Adaptive All-In-One Delivery Chip for Rapid Skin Nerves Regeneration by Endogenous Mesenchymal Stem Cells. Advanced Functional Materials (2020, 2001751) Li-Hua Peng*, Yan-Fen Huang, Chen-Zhen Zhang, Jie Niu, Ying Chen, Yang Chu, Zhi-Hong Jiang, Jian-Qing Gao, Zheng-Wei Mao. Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity. Biomaterials 103 (2016) 137-149. Haseeb Anwar Dad#, Ting-Wei Gu, Ao-Qing Zhu, Lu-Qi Huang, Li-Hua Peng*,Plant derived outer membrane vesicles: Emerging therapeutics and delivery nanoplatforms, Molecular Therapy, 2020. https://doi.org/10.1016/j.ymthe.2020.11.030 Li-Hua Peng, Jie Niu, Chen-Zhen Zhang, Wei Yu, Jia-He Wu, Ying-Hui Shan, Xia-Rong Wang, You-Qing Shen, Zheng-Wei Mao, Wen-Quan Liang, Jian-Qing Gao. TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells. Biomaterials. 2014, 35, 5605-5618. Li-Hua Peng, Zhang YH, Han LJ, Zhang CZ, Wu JH, Wang XR, Gao JQ, Mao ZW. Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo. ACS Appl Mater Interfaces. 2015. 7(33):18628-37. Jie Niu,Yang Chu,Yan-Fen Huang,Yee-Song Chong, Zhi-Hong Jiang, Zheng-Wei Mao, Li-Hua Peng*, Jian-Qing Gao, Transdermal Gene Delivery by Functional Peptide Conjugated Cationic Gold Nanoparticle Reverse the Progression and Metastasis of Cutaneous Melanoma, ACS Appl. Mater. Interfaces, 2017; 9(11):9388-9401. M.Z. Wang#, J. Niu#, H.J. Ma, H.A. Dad, H.T. Shao, T.J. Yuan, L.H. Peng*, Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression. Journal of Controlled Release, 2020, 10.1016/j.jconrel.2020.03.023. Li-Hua Peng, Suk-Ying Tsang, Yasuhiko Tabata, Jian-Qing Gao. Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration, J Control Release, 2012;157(3):321-30. Li-Hua Peng, Kwok-Pui Fung, Ping-Chung Leung, Jian-Qing Gao. Genetically manipulated adult stem cells for wound healing, Drug Discovery Today, 2011,16(21/22):957-966. Ting-Wei Gu, Mao-Ze Wang, Jie Niu, Yang Chu, Ke-Ran Guo, Li-Hua Peng* Outer membrane vesicles derived from E.coli as novel vehicles for transdermal and tumor targeting delivery, Nanoscale (DOI: 10.1039/D0NR03698F 2020) Ni Li, Li-Hua Peng*, Xi Chen, Tian-Yuan Zhang, Guo-Feng Shao, Wen-Quan Liang, Jian-Qing Gao. Antigen-loaded nanocarriers enhance the migration of stimulated Langerhans cells to draining lymph nodes and induce effective transcutaneous immunization. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10(1):215-23. Li-Hua Peng, Shen-Yao Xu, Ying-Hui Shan, Wei Wei, Shuai Liu, Chen-Zhen Zhang, Jia-He Wu, Wen-Quan Liang, Jian-Qing Gao, Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin. International Journal of Nanomedicine, 2014:9 1897–1908. Xue-Han Xu, Tie-Jun Yuan, Pei-Wu Ye, Mao-Ze Wang, Hui-Jian Ma, Zhi-Hong Jiang, Yong-Pin Zhang*, Li-Hua Peng*, Construction of a biomimetic chemokine reservoir stimulates rapid in situ wound repair and regeneration. International Journal of Pharmaceutics 570 (2019) 118648. Chen-Zhen Zhang; Jie Niu; Yee-Song Chong; Yan-Fen Huang; Yang Chu; Sheng-Yang Xie; Zhi-Hong Jiang; Li-Hua Peng*, Porous microspheres as promising vehicles for the topical delivery of poorly soluble asiaticoside accelerate wound healing and inhibit scar formation in vitro & in vivo. European Journal of Pharmaceutics and Biopharmaceutics. 2016;109:1-13. Long-Jian Li, Xue-Han Xu, Tie-Jun Yuan, Jian Hou, Chui-Liang Yu, Li-Hua Peng*, Periplaneta Americana L. as a novel therapeutics accelerates wound repair and regeneration. Biomed Pharmacother. 2019;114:108858. doi: 10.1016/j.biopha.2019.108858. Yang Chu, Jin Gao, Jie Niu, Yan-Fen Huang, Ming Chen, Mao-Ze Wang, Qiang Shang, Wen-Qi Lu, Li-Hua Peng*, Zhi-Hong Jiang, Synthesis, characterization and inhibitory effects of crocetin derivative compounds in cancer and inflammation, Biomedicine & Pharmacotherapy (2017) 98:157-164. Li-Hua Peng, Wei Wei, Ying-Hui Shan, Tian-Yuan Zhang, Chen-Zhen Zhang, Jia-He Wu, Lian Yu, Jun Lin, Wen-Quan Liang, Gilson Khang, and Jian-Qing Gao, beta-Cyclodextrin-Linked Polyethylenimine Nanoparticles Facilitate Gene Transfer and Enhance the Angiogenic Capacity of Mesenchymal Stem Cells for Wound Repair and Regeneration. Journal of biomedical nanotechnology, 11(4) 680-690, 2014. Li-Hua Peng, Wei, Wei, Qi, Xiao-Tian, Shan, Ying-Hui, Zhang, Fang-Jun, Chen, Xi, Zhu, Qian-Ying, Yu, Lian, Liang, Wen-Quan, Gao, Jian-Qing. Epidermal stem cells manipulated by pDNA-VEGF165/CYD-PEI nanoparticles loaded gelatin/beta-TCP matrix as therapeutic agent and gene delivery vehicle for wound healing. Molecular Pharmaceutics. 2013, 10 (8), 3090-3102. Li-Hua Peng, Shuai Liu, Shen-Yao Xu, Lei Chen, Ying-Hui Shan, Wei Wei, Wen-Quan Liang, Jian-Qing Gao, Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin. Phytomedicine. 2013, 20(12):1082-1087. Yang Chen, Dongmei Cun, Dongmei Cun, Xiaochang Liu, Wenjia Guo, Li-Hua Peng*, Liang Fang. Saturated long-chain esters of isopulegol as novel permeation enhancers for transdermal drug delivery. Pharmaceutical Research. 2014, (8) 1907-18.

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