个人简介
学历背景：
杭州大学理学学士（化学，1990）、中国科学院上海药物研究所理学硕士（有机化学，1993）、中国科学院上海药物研究所理学博士（有机化学，1996），美国康涅狄格大学哲学博士（Pharmaceutical Sciences，2005）。
国外学习与研究： 1998年~ 2001年：美国康涅狄格大学材料科学研究所（Institute of Material Sciences, University of Connecticut，USA）访问学者； 2001年~ 2005年：美国康涅狄格大学药学院（School of Pharmacy, University of Connecticut，USA）博士研究生； 2005年~ 2006 年：美国休斯顿大学药学院（College of Pharmacy, University of Houston，USA）博士后； 2006年~ 2008年：美国匹兹堡大学药学院（School of Pharmacy, University of Pittsburgh，USA）Res. Asso.。
工作经历： 1996年~ 1998年：中国科学院上海药物研究所，助理研究员； 2008年~ 2011：浙江大学药学院，研究员，博士生导师； 2012年~至今：浙江大学药学院，教授，博士生导师。
近期论文
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1. Shuang Han, Fei-Fei Zhang, Hai-Yan, Li-Li Chen, Xin Xie, Jian-Zhong Chen* Design, Syntheses, Structure-Activity Relationships and Docking Studies of Coumarin Derivatives as Novel Selective Ligands for the CB2 Receptor. Eur. J. Med. Chem, 2015, 93, 16-32.
2. T. A. Chohan, H. Qian, Y. Pan, J.-Z. Chen* Cyclin-dependent kinase-2 as a target for cancer therapy: Progress in the development of CDK2 inhibitors as anti-cancer agents. Curr. Med. Chem. 2015, 22, 237-263
3. Y. Cao, S. Han, L. Yu, H. Qian, J.-Z. Chen*. MD and QM/MM Studies on Long-Chain L‑α-Hydroxy Acid Oxidase: Substrate Binding Features and Oxidation Mechanism. J. Phys. Chem. B 2014, 118, 5406−5417.
4. S. Han, J.-J. Chen, J.-Z. Chen* Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor Mini-Rev. Med. Chem., 2014, 14, 426-443.
5. Shuang Han, Fei-Fei Zhang, Xin Xie, Jian-Zhong Chen*, Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists. Eur. J. Med. Chem., 2014, 74, 73-84
6. Yang Cao, Zhong-Jian Chen, Hui-Di Jiang, and Jian-Zhong Chen*. Computational Studies of the Regioselectivities of COMT-Catalyzed Meta-/Para-O Methylations of Luteolin and Quercetin. J. Phys. Chem. B 2014, 118, 470−481
7. Lushan Yu, Jianbin Pu, Minjuan Zuo, Xia Zhang, Yang Cao, Shifeng Chen, Yan Lou, Quan Zhou Haihong Hu, Huidi Jiang, Jianzhong Chen*, and Su Zeng*. Hepatic Glucuronidation of Isoneochamaejasmin A from the Traditional Chinese Medicine Stellera Chamaejasme L. Root. Drug Metab. Dispos. 2014, 42:1–9.
8. Shi-Feng Chen, Yang Cao, Shuang Han, Jian-Zhong Chen* Insight into the structural mechanism for PKB _ allosteric inhibition by molecular dynamics simulations and free energy calculations. J. Mol. Graph. Model. 48 (2014) 36–46
9. Shi-Feng Chen & Yang Cao & Jiong-Jiong Chen, Jian-Zhong Chen*. Binding selectivity studies of PKBαusing molecular dynamics simulation and free energy calculations. J. Mol. Model. 2013, 19:5097-5112,
10. Shifeng Chen, Jianzhong Chen*, Development for anticancer therapy small-molecule inhibitors targeting protein kinase B. Mini-Rev. Med. Chem.,2013, 23:1272-1294,
11. Jiong-Jiong chen, Shuang Han, Yang Cao, Jian-Zhong Chen*,The agonist binding mechanism of human CB2 receptor studied by molecular dnamics simulation, free energy calculation and 3D-QSAR studies, 药学学报2013，48:1436-1449，
12. Lili Ou, Shuang Han, Wenbo Ding, Zhe Chen, Ziqi Ye, Hongyu Yang, Goulin Zhang, Yijia Lou, Jian-Zhong Chen*, Yongping Yu*. Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives, Mol. Diver. 2011, 15:665–675.
13. Lili Ou, Shuang Han, Wenbo Ding, Ping Jia, Bo Yang, Jose L. Medina-Franco, Marc A. Giulianotti, Jian-Zhong Chen*, Yongping Yu*, Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR. Mol. Diver. 2011, 15:927–946.
14. Chaoyi Jiang, Shuang Han, Tiegang Chen, Jianzhong Chen*. 3D-QSAR and docking studies of arylmethylamine-based DPP IV inhibitors Acta Pharmaceutica Sinica B 2012, 2(4):411–420
15. J.-Z. Chen, K.-Z. Myint, X.-Q. Xie, New QSAR prediction models derived from GPCR CB2-antagonistic triaryl bis-sulfone analogues by a combined molecular morphological and pharmacophoric approach. SAR and QSAR in Environmental Research. (2011), 22(5-6): 525–544.
16. 刘瑶, 洪岚, 余露山, 蒋惠娣, 陈建忠, 孟琴, 陈枢青, 曾苏，创新药物转化研究中ADME 的评价，药学学报，2011, 46 (1): 19-29
17. Jurg Gertsch, Marco Leonti, Stefan Raduner, Ildiko Racz, Jian-Zhong Chen, Xiang-Qun Xie, Karl-Heinz Altmann, Meliha Karsak, and Andreas Zimmer, Beta-caryophyllene is a dietary cannabinoid. PNAS, 2008, 105: 9099-9014
18. Xiang-Qun Xie, Jian-Zhong Chen, Data-Mining Representative Small Molecule Drug Screening Database from NIH PubChem. Journal of Chemical Infomatics and Modeling, 2008, 48: 465-475.
19. Shuli Mao, Donald Probst, Stefan Werner, Jian-Zhong Chen, Xiangqun Xie, and Kay M. Brummond Diverging Rh(I)-Catalyzed Carbocylization Strategy to Prepare a Library of Unique Cyclic Ethers.J. Comb. Chem., 2008, 10: 235-246.
20. Jian-Zhong Chen, Junmei Wang, Xiang-Qun Xie. GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search. J. Chem. Info. Modeling, 2007, 47(4), 1626-1637.
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