蒋惠娣 - 浙江大学

个人简介

1、教育经历 2000.9～2004.6 浙江大学医学院，生理学博士 1988.9～1992.7 浙江医科大学药学系，药物分析学硕士 1982.8～1986.7 浙江医科大学药学系，理学学士 2、工作经历 2005.12～浙江大学药学院，教授 2007.1～2008.12 美国密歇根大学药学院访问学者 1997.12～2005.12 浙江医科大学、浙江大学药学院，副教授 1998.9～1999.2 日本歧阜药科大学访问学者 1992.12~1997.12 浙江医科大学药学系，讲师 1986.8~1992.12 浙江医科大学药学系，助教

研究领域

药物转运与代谢；药物转运体与疾病；代谢性药物(食物)-药物相互作用；创新药物非临床药代动力学

近期论文

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1. Wang YQ, Sun DL, Song FF, Hu YJ, Smith DE, Jiang HD*. Expression and regulation of proton-coupled oligopeptide transporter PhT2 by LPS in macrophages and mouse spleen. Mol Pharm, 2014, 11(6):1880-8. 2. Tu MJ#, Li LP#, Lei HM, Ma ZY, Chen ZJ, Sun SY, Xu SY, Zeng S, Jiang HD*. Involvement of Organic Cation Transporter1 and Cytochrome P450 3A4 in Retrorsine Induced Toxicity. Toxicology, 2014, 322C:34-42. 3. Li LP, Song FF, Tu MJ, Wang K, Zhao L, Wu XD, Zhou H, Xia ZL, Jiang HD*. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. Int J Pharm, 2014, 465(1-2):5-10. 4. Li LP#, Tu MJ#, Yang X, Sun SY, Wu XD, Zhou H, Zeng S, Jiang HD*. The contribution of human OCT1, OCT3 and CYP3A4 to the nitidine chloride induced hepatocellular toxicity. Drug Metab Dispos, 2014, 42:1227-34. 5. Sun SY#, Wang K#, Lei HM, Li LP, Tu MJ, Zeng S, Zhou H*, Jiang HD*. Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuropsychopharmacol Biol Psychiatry, 2014,49:1-6. 6. Wang K, Sun SY, Li LP, Tu MJ, Jiang HD*. Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry, 2014,53: 90-8. 7. Tu MJ, Sun SY, Wang K, Peng XY, Wang RH, Zeng S, Zhou H*, Jiang HD*. Organic cation transporter 1 mediates the uptake of monocrotaline and plays a key role in its hepatotoxicity. Toxicology, 2013, 311(3):225-30. 8. Sun DL, Wang YQ, Tan FQ, Fang DB, Hu YJ, Smith DE, Jiang HD*. Functional and Molecular Expression of the Proton-Coupled Oligopeptide Transporters in Spleen and Macrophages from Mouse and Human. Mol Pharm, 2013,10(4):1409-16. 9. Sun DL, Tan FQ, Fang DB, Wang YQ, Zeng S, Jiang HD*. Expression of Proton-Coupled Oligopeptide Transporter (POTs) in Prostate of Mouse and Patients with Benign Prostatic Hyperplasia and Prostate Cancer. Prostate, 2013, 73(3): 287-95. 10. Chen ZJ, Dai YQ, Kong SS, Song FF, Li LP, Ye JF, Wang RW, Zeng S, Zhou H*, Jiang HD*. Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation. Mol Nutr Food Res, 2013, 57(5):877-85. 11. Pan H, Gu LQ, Sun SY, Chen ZJ, Zhou H, Zeng S, Jiang HD*. Metabolism of Bis(4-fluorobenzyl)2 trisulfide and its formation of hemoglobin adduct in rat erythrocytes. Drug Metab Dispos, 2013, 41(5):1082-93. 12. Chen ZJ, Chen M, Pan H, Sun SY, Li LP, Zeng S, and Jiang HD*. Role of Catechol-O-methyl transferase in the disposition of luteolin in rats. Drug Metab Dispos, 2011, 39 (4):667-74