个人简介
1、学历背景：
1982年浙江医科大学医学学士
1986年浙江医科大学医学硕士
1999年浙江大学理学博士
2、国外学习研究经历：
1990年至1992年：美国犹他大学访问学者
1998年至1999年：美国南卡罗来那医科大学高级访问学者
3、工作经历：
1986年至1998年任浙江医科大学药学系助教、讲师、副教授和教授。
1999年7月至今任浙江大学药学院教授、博士生导师。
研究领域
手性药物和中药分析 药物在生物体内转运与代谢 药酶和转运体相关转基因模型的建立及其应用 药物质量控制
近期论文
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1. Wang Y, Hu HH, Pang H, Zhou XY, Yu LS, Wang LL, Liu C, Guo KN, Zhao C, Liu Q, Zeng BH, Tang H, Shang HT, Zeng S, Wei H. Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner. PLoS One.2012;7(1):e30560
2. Yu L, Wang S, Jiang H, Zhou H, Zeng S.Simultaneous determination of fluoxetine and norfluoxetine enantiomers using isotope discrimination mass spectroscopy solution method and its application in the CYP2C9-mediated stereoselective interactions.J Chromatogr A. 2012 May 4;1236:97-104.
3. Li L, Hu H, Xu S, Zhou Q, Zeng S，Roles of UDP-glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-drug Interactions. Curr Drug Metab. 2012 Mar 28. [Epub ahead of print] PMID:22475332.
4. Wang H, Yuan L, Zeng S. Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen. Biochem Pharmacol, 2011,82: 1757-1763
5. Yu C, Chai X, Yu L, Chen S, Zeng S.Identification of novel pregnane X receptor activators from traditional Chinese medicines.J Ethnopharmacol. 2011；136(1):137-43
6. Zhang X, Yao Y, Lou Y, Jiang H, Wang X, Chai X, Zeng S. Metabolism of ebracteolata compound B studied in vitro with human liver microsomes, HepG2 cells, and recombinant human enzymes. Drug Metab Dispos. 2010;38:2157-65.
7. Liu ZH, Zeng S.Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes. Toxicol Lett. 2009;187(3):131-6.
8. Wang XD, Meng MX, Gao LB, Liu T, Xu Q, Zeng S.Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp.Int J Pharm, 2009;378(1-2):1-8. 9. Chen Y, Xie S, Chen S, Zeng S. Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A
9. Biochem Pharmacol. 2008 Aug 1;76(3):416-25.
10. Yu L, Lu S, Lin Y, Zeng S. Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. Biochem Pharmacol. 2007 Jun 1;73(11):1842-51.
11. Chen YK, Chen S, Li X, Wang X, Zeng S. Genetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han Population. Drug Metab Dispos. 2006, 31; 34:1-6
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