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个人简介

博士,2004年晋升教授、博士生导师,现任浙江大学药物信息学研究所所长、浙江大学药学院中药科学与工程学系主任,浙江省中医药重点实验室(中药制药工程)主任;兼任中华中医药学会中药制药工程分会副主任委员,中国药学会制药工程专业委员会委员,中华中医药学会中医药信息学分会常务委员,中国医药信息学会药物分析信息学专业委员会副主任委员,浙江省药学会制药工程专业委员会名誉主任委员,中国仪器仪表学会近红外光谱分会常务理事,创新中药关键技术国家重点实验室学术委员会委员;入选教育部新世纪优秀人才支持计划、浙江省“新世纪151人才工程”重点资助。近年来,负责主持国家科技重大专项“重大新药创制”项目、国家973项目、国家“十五”科技攻关计划项目、国家自然科学基金项目等,参与多项国家级课题研究,发表学术论文200余篇,其中被SCI收录140余篇。获国家科学技术进步奖一等奖1项(2014年)、二等奖1项(2004年),省科学技术奖一等奖1项、二等奖3项、三等奖2项,第八届浙江省青年科技奖。 教育和工作经历 2004.12-今 教授,浙江大学药学院 浙江大学药物信息学研究所 2003.1—2004.11 副教授,浙江大学药学院 浙江大学药物信息学研究所 2001.1—2002.12 副教授,浙江大学材化学院 浙江大学制药工程研究所 1997.6—2000.12 讲师,浙江大学信电系 1992.9—1997.5 博士研究生,浙江大学工业控制技术国家重点实验室 1990.7—1992.8 助理工程师,上海宝钢化工公司 1986.9—1990.7 本科生,浙江大学化工系

研究领域

(1)药品质量源于设计(QbD)及制药过程分析技术(PAT) (2)制药过程模型化及优化 (3)中药分析及质量控制 (4)制药工业大数据分析 (5)PAT/QbD在抗体制备中应用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Yan, X., Fu, H., Zhang, S., & Qu, H. (2019). Combining Convolutional Neural Networks and In‐line Near‐infrared Spectroscopy for Real‐ ime Monitoring of the Chromatographic Elution Process in Commercial Production of Notoginseng Total Saponins. Journal of separation science. Yan, X., Li, W., Zhang, X., Liu, S., & Qu, H. (2019). Development of an on‐line Raman spectral analytical method for monitoring and endpoint determination of the Cornu Caprae Hircus hydrolysis process. Journal of Pharmacy and Pharmacology. Zhao, J., Li, W., Qu, H., Tian, G., & Wei, Y. (2019). Application of definitive screening design to quantify the effects of process parameters on key granule characteristics and optimize operating parameters in pulsed-spray fluid-bed granulation. Particuology, 43, 56-65. Zhang, Y., Ye, T., Hong, Z., Gong, S., Zhou, X., Liu, H., ... & Qu, H. (2019). Pharmacological and transcriptome profiling analyses of Fufang E'jiao Jiang during chemotherapy-induced myelosuppression in mice. Journal of ethnopharmacology, 238, 111869. Zhang, Y., Ye, T., Gong, S., Hong, Z., Zhou, X., Liu, H., ... & Qian, J. (2019). RNA-sequencing based bone marrow cell transcriptome analysis reveals the potential mechanisms of E'jiao against blood-deficiency in mice. Biomedicine & Pharmacotherapy, 118, 109291. Shen, L., Yan, X., Nie, L., Xu, W., Miao, S., Wang, H., ... & Qu, H. (2019). Chemometric identification of canonical metabolites linking critical process parameters to monoclonal antibody production during bioprocess development. Chinese Journal of Chemical Engineering, 27(5), 1171-1176. Li, W., Yan, X., Pan, J., Liu, S., Xue, D., & Qu, H. (2019). Rapid analysis of the Tanreqing injection by near-infrared spectroscopy combined with least squares support vector machine and Gaussian process modeling techniques. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Zhang, S., Xiong, H., Zhou, L., Ju, W., Yang, Z., Yan, K., ... & Qu, H. (2019). Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product. Journal of pharmaceutical and biomedical analysis, 174, 674-682. Nie, L., Gao, D., Jiang, H., Gou, J., Li, L., Hu, F., ... & Qu, H. (2019). Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design. AAPS PharmSciTech, 20(6), 246. Ye, T., Qu, H., & Gong, X. *(2019). Preparation of Salvianolic Acid B Disodium Salt Considering the Water Extract Quality Standard. Molecules, 24(7), 1269.(非通讯作者) Yan, X., Zhang, S., Fu, H., & Qu, H. (2019). Combining convolutional neural networks and on-line Raman spectroscopy for monitoring the Cornu Caprae Hircus hydrolysis process. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 117589. Sun, M. F., Yang, J. Y., Cao, W., Shao, J. Y., Wang, G. X., Qu, H. B., ... & Gong, X. C.* (2019). Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method. Chinese Herbal Medicines.(非通讯作者) Tian, G., Wei, Y., Zhao, J., Li, W., & Qu, H. (2018). Application of near-infrared spectroscopy combined with design of experiments for process development of the pulsed spray fluid bed granulation process. Powder Technology, 339, 521-533. Huang, H., & Qu, H. (2018). In-situ monitoring of saccharides removal of alcohol precipitation using near-infrared spectroscopy. Journal of Innovative Optical Health Sciences, 11(05), 1850027. Li, W., Yan, X., Chen, H., & Qu, H. (2018). In-line Vis-NIR spectral analysis for the column chromatographic processes of Ginkgo biloba part I: End-point determination of the elution process. Chemometrics and Intelligent Laboratory Systems, 172, 159-166. Nie, L., Hu, M., Yan, X., Guo, T., Wang, H., Zhang, S., & Qu, H. (2018). Optimization of a Coupling Process for Insulin Degludec According to a Quality by Design (QbD) Paradigm. AAPS PharmSciTech, 19(5), 2185-2194. Shao, J., Cao, W., Qu, H., Pan, J., & Gong, X.* (2018). A novel quality by design approach for developing an HPLC method to analyze herbal extracts: A case study of sugar content analysis. PloS one, 13(6), e0198515.(非通讯作者) Gong, X., Huang, S., Pan, J., & Qu, H. (2017). Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values. Chinese Journal of Chemical Engineering, 25(1), 68-73. Luo, Y., Li, W*. L., Huang, W. H., Liu, X. H., Song, Y. G., & Qu, H. B. (2017). Rapid quantification of multi-components in alcohol precipitation liquid of Codonopsis Radix using near infrared spectroscopy (NIRS). Journal of Zhejiang University-SCIENCE B, 18(5), 383-392.(非通讯作者) Ye, T., Qu, H., & Gong, X*. (2017). Measurement and Correlation of Liquid–Liquid Equilibria for the Ternary Systems of Water+ d-Fructose+ 1-Butanol, Water+ d-Glucose+ 1-Butanol, and Water+ d-Galactose+ 1-Butanol at (288.2, 303.2 and 318.2) K. Journal of Chemical & Engineering Data, 62(8), 2392-2399.(非通讯作者)

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