个人简介
本科92年毕业于上海医科大学获学士学位，99年在日本冈山大学获得硕士和博士学位。国家杰出青年科学基金获得者、教育部长江学者特聘教授，国务院政府特殊津贴获得者、浙江大学求是特聘教授、教育部新世纪优秀人才、浙江省首批卫生领军人才、浙江省151人才重点培养层次、教育部和国家基金委神经科学创新研究群体核心骨干、浙江省小分子药物研发关键技术创新团队负责人、浙江省首批卫生领军人才、浙江省十二五生物制药重大专项专家组组长、参与获得国家自然科学二等奖和省科技进步一等奖，浙江大学第四届研究生“五好”导学团队。曾任浙江大学基础医学院副院长、药学院常务副院长兼医学部副主任，浙江中医药大学副校长，卫生部医学神经生物学重点实验室和浙江省神经生物学重点实验室副主任。多次赴日本东北大学，美国宾夕法尼亚大学，加拿大多伦多大学进行合作研究。中国药理学学会常务理事，中国药理学会神经精神药理学专业委员会副主任委员，浙江省药理学会理事长。《Neurosci Bull》副主编，《CNS Neurosci Ther》《Clin Exp Pharmacol Physiol》《Acta Pharmacol Sin》编委以及《药学学报》《中国药理学通报》《浙江大学学报》编委。
近期论文
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1. Ying X, Wang Y, Liang J, Yue J, Xu C, Lu L, Xu Z, Gao J, Du Y, Chen Z. Angiopep-Conjugated Electro-Responsive Hydrogel Nanoparticles: Therapeutic Potential for Epilepsy. Angew Chem Int Ed Engl. 2014 Jul 18. doi: 10.1002/anie.201403846. [Epub ahead of print]
2. Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, Dai H, Hu WW, Zhang Z, Chen Z. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. doi: 10.4161/auto.32136. Epub 2014 Aug 5.
3. Hu WW, Wang Z, Zhang SS, Jiang L, Zhang J, Zhang X, Lei QF, Park HJ, Fang WJ, Chen Z. Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces. Biomaterials. 2014 Aug;35(26):7386-97. doi: 10.1016/j.biomaterials.2014.05.026. Epub 2014 Jun 2.
4. Yan H, Zhang X, Hu W, Ma J, Hou W, Zhang X, Wang X, Gao J, Shen Y, Lv J, Ohtsu H, Han F, Wang G, Chen Z. Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. Nat Commun. 2014 Feb 25;5:3334. doi: 10.1038/ncomms4334.
5. Wang Y, Xu ZH, Cheng H, Guo Y, Xu CL, Wang S, Zhang JM, Ding MP, Chen Z*. Low-frequency stimulation inhibits epileptogenesis by modulating the early network of the limbic system as evaluated in amygdala kindling model. Brain Structure & Function, 2013 Jun 11. [Epub ahead of print
6. Fan YY, Shen Z, He P, Jiang L, Hou WW, Shen Y, Zhang XN, Hu WW, Chen Z. A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion.J Cereb Blood Flow Metab. 2014 Feb;34(2):275-83
7. Liu J, Ye J, Zou X, Xu Z, Feng Y, Zou X, Chen Z, Li Y, Cang Y. CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis. Nat Commun. 2014 May 21;5:3924. doi: 10.1038/ncomms4924
8. Xu Z, Wang Y, Jin M, Yue J, Xu C, Ying X, Wu D, Zhang S, Chen Z. Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats. Brain Stimul. 2013 Mar;6(2):190-7
9. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan S, Yu YQ. Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Curr Biol. 2014 Mar 17;24(6):693-8. doi: 10.1016/j.cub.2014.02.011. Epub 2014 Mar 6
10. Zhang XN, Yan HJ, Yuan Y, Gao JQ, Shen Z, Cheng Y, Shen Y, Wang RR, Wang XF, Hu WW, Wang GH, Chen Z *. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondria clearance. Autophage. 2013 Sep;9(9):1321-33
11. Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan S, Li XM. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011 Dec 11;15(2):267-73. doi: 10.1038/nn.3006
12. Fan YY, Hu WW, Dai HB, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z*. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cerebr Blood F Met. 2011 Jan;31(1):305-14 (IF=5.457) DOI: 10.1038/jcbfm.2010.9
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