个人简介
ACADEMIC QUALIFICATIONS
Post-doc (2008-2011):Massachusetts Institute of Technology (Advisor: Prof. Peter C. Dedon)
Ph.D. (2004-2008):Hong Kong Baptist University (Advisor: Prof. Zongwei Cai)
B.Sc. (2001-2004):Hong Kong University of Science and Technology
FELLOWSHIP AND AWARDS
2018"2018 Young Investigator Award" jointly by American Chemical Society (ACS) Division of Chemical Toxicology and ACS journal Chemical Research in Toxicology
2017“2017 Research Article of the Year Award Lectureship" jointly by American Chemical Society (ACS) Division of Agrochemicals and ACS journal Journal of Agricultural and Food Chemistry
2010 Merck Award of Achievement; by American Chemical Society Division of Chemical Toxicology
2009 MIT Center for the Environmental Health Sciences Outstanding Poster Award; MIT
2007 Baptist Chemists Postgraduate Paper Award for the outstanding achievement in research publications; Hong Kong Baptist University
2006 Dr. Wu Yee Sun Memorial Scholarship Fund on the basic of academic merit; Hong Kong Baptist University
研究领域
Current research focus on developing chromatographic and mass spectrometric methods: 1) to identify and quantify toxic chemicals for food safety testing; 2) to study chemically- and physically-induced damage to biological macromolecules, such as DNA, RNA, and proteins, that related to human diseases; and 3) to investigate the biological consequences of external stimuli by using a systematic metabolomics approach.
近期论文
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Kwok HC; Chan W*, (2022) Wheatgrass (Triticum aestivum) as an Efficient Phytoremediation Plant for Aristolochic Acid-Contaminated Water and Arable Soil. ACS Agricultural Science & Technology, Accepted.
Zhang J, Chan KK, Chan W*, (2022) Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy. Chem Res Toxicol, 35(5): 849–857.
Ham YH, Pan G, Chan HW, Chan W*, (2022) LC-MS/MS Quantitation of Formaldehyde-Glutathione Conjugates as Biomarkers of Formaldehyde Exposure and Exposure-Induced Anti-Oxidants: A New Look on an Old Topic. Chem Res Toxicol, 35(5): 858–866.
Chan W*, Jin L, (2022) DNA-Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope Dilution. Anal Chem, 94(2): 803-810.
Jin L, Griffith S, Sun Z, Yu JZ, Chan W*, (2021) On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution. Environ Sci Technol, 55(20):14095-14104.
Chan W*, Guo W, Yu JZ, (2021) Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke. Anal Chem, 93(41):13912-13918.
Chan CK, Xiong L, Pavlović NM, Chan W*, (2021) Determination of Aristolochic Acids in Soil, Water and Herbal Plants in Medicinal Plant Cultivation Areas: An Emerging Environmental Contaminant Worth Concerning. ACS Agric Sci Technol, 1(5): 522-528.
Chan W* and Ham YH, (2021) Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy. Chem Res Toxicol, 34(8): 1903-1909.
Guo W, Zhang J, Sun Z, Orem W.H, Tatu CA, Radulović NS, Milovanović D, Pavlović NM*, and Chan W*, (2021) Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid I and Balkan Endemic Nephropathy. Environ Sci Technol, 55(13): 9024-9032.
Chan W*, Zhao Y, Chan K-K, (2021) Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines. ACS Food Sci Technol, 1(5): 892-898.
Chan W*, Jin L, Sun Z, Griffith S,* Yu JZ*, (2021) Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons. Environ Sci Technol, 55(8): 5128-5135.
Chan CK, Chan KKJ, Liu N*, Chan W*, (2021) Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography−Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure Cells. Chem Res Toxicol, 34(1): 144–153.
Ham YH, Chan KKJ, Madej D, Lam H, Chan W*, (2020) Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe2+-EDTA-Exposed Human Cells. Chem Res Toxicol. 33(11): 2739–2744.
Au CK, Zhang J, Chan CK, Li C, Liu G, Pavlovic NM, Yao J, Chan W*, (2020) Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy.Chem Res Toxicol, 33(9): 2446–2454.
Chan CK, Pan G, and Chan W*, (2020) Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry. J. Mass Spectrom, accepted
Pan GR, Ham YH, Chan HW, Yao J, Chan W*, (2020) LC-MS/MS Coupled With a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- And Oxidative Stress-Exposed Cells. Chem Res Toxicol, 33(7): 1989-1996.
Ham YH, Chan KJ, Chan W*, (2020) Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability. Chem Res Toxicol. 33(7): 1815-1821.
Chan CK, Tung KK, Pavlović NM, Chan W*, (2020) Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process. Sci Total Environ. 720:137528. doi: 10.1016/j.scitotenv.2020.137528
Au CK, Chan CK, Tung KK, Zhang J, Chan W*, (2020) Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism. Chem Res Toxicol. 33(6): 1323-1327.
Zhang J, Chan CK, Ham YH, Chan W*, (2020) Identifying Cysteine, N-Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway. Chem Res Toxicol. 33(6): 1374-1381.
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