个人简介

2006 Ph.D. in Chemical Physics, Columbia University (Thesis advisor: B. J.Berne) 2001 B.S. in Chemical Physics, University of Science and Technology of China (USTC) PROFESSIONAL EXPERIENCE Jan 2015-Present Associate Professor, Department of Chemistry, The Hong Kong University of Science and Technology Jan 2015-Present Associate Professor (Joint appointment), Division of Biomedical Engineering, The Hong Kong University of Science and Technology Oct 2011-Dec 2014 Assistant Professor (Joint appointment), Division of Biomedical Engineering, The Hong Kong University of Science and Technology Jan 2010- Dec 2014 Assistant Professor, Department of Chemistry, The Hong Kong University of Science and Technology Sep 2008-Dec 2009 Research Associate, Department of Bioengineering, Stanford University Aug 2006-Aug 2008 Simbios Distinguished Postdoctoral Scholar, Stanford University (Advisor: M. Levitt, Nobel Laureate in Chemistry 2013 , and V. S. Pande ) FELLOWSHIP AND AWARDS 2014 American Chemical Society OpenEye Outstanding Junior Faculty Award 2013 School Research Award, School of Science, HKUST 2013 Early Career Award, Research Grant Council (RGC) of Hong Kong. 2006 CCG Excellence Award, American Chemical Society, Division of COMP. 2001-2006 Faculty Fellowship, Columbia University 2003-2004 Blanche R. and David Kasindorf Fellowship in Physical Chemistry

研究领域

Computational biophysics and biophysical chemistry. Particular areas of interests include protein folding/misfolding and aggregration, RNA folding, elucidating fundamental mechanism of cellular machineries, and developing theoretical tools for studying conformational dynamics.

The main goal of our lab is to understand and manipulate functional conformational changes of complex biological systems by developing and applying novel computational tools which bridge the gap between experiments and simulations. Examples of our interested research areas include protein misfolding and aggregation, functional conformational changes in Transcription, and the development of Kinetic Network Models for long timescale dynamics.

近期论文

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Lu, L., Meehan, M., Gu, S., Chen, Z., Zhang, W., Zhang, G., Liu, L., Huang, X., Dorrestein, P., Xu, Y., Moore, B., Qian, P.,""Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors"", Sci. Rep., 5, 8783, (2015) Xu, L., Wang, W., Zhang, L., Chong, J., Huang, X., Wang, D., ""Impact of template backbone heterogeneity on RNA polymerase II transcription"", Nucl. Acids Res., 43 (4), 2232-2241, (2015) Zhao, E., Lam, J., Meng, L., Hong, Y., Deng, H., Bai, G., Huang, X., Hao, J., Tang, B., ""Aoly[(maleic anhydride)-alt-(vinyl acetate)]: A Pure Oxygenic Nonconjugated Macromolecule with Strong Light Emission and Solvatochromic Effect"", Macromolecules, 48 (1), 64–71, (2015) Sheong, F.K., Silva, D.A., Meng, L., Zhao, Y., Huang, X. ""Automatic state Partitioning for Multi-body systems (APM): An Efficient Algorithm for Constructing Markov State Models to Elucidate Conformational Dynamics of Multi-body Systems"", J. Chem. Theory Comput., 11 (1), 17–27, (2015) Liu, Y., Mu, C., Jiang, K., Zhao, J., Li, Y., Zhang, L., Li, Z., Lai, J., Hu, H., Ma, T., Hu, R., Yu, D., Huang, X., Tang, B., Yan, H. ""A Tetraphenylethylene Core-Based 3D Structure Small Molecular Acceptor Enabling Efficient Non-Fullerene Organic Solar Cells"", Adv. Mater., 27(6), 1015-1020, (2015) Yu, J., Da, L.T., Huang, X., ""Constructing Kinetic Models to Elucidate Structural Dynamics of a Complete RNA Polymerase II Elongation Cycle"", Phys. Bio., 12, 016004, (2015) Gu, S., Silva, D.A., Meng, L., Yue, A., Huang, X., ""Quantitatively Characterizing the Ligand Binding Mechanisms of Choline Binding Protein using Markov State Model Analysis"", PLoS. Comp. Bio., 10(8):e1003767, (2014) Xu, L, Zhang, L., Chong, J., Xu, J., Huang, X., Wang, D., ""A Chemical Perspective on Transcriptional Fidelity and Evolution: Asymmetric Recognition of Phosphodiester Linkage by RNA Polymerase II"", Proc. Nat. Acad. Sci. U.S.A., 111, E3269–E3276, (2014) Fu, A., Hung, K.W., Huang, H., Gu, S., Shen, Y., Cheng, Ip, F.,, Huang, X, Fu, W.,,Ip, N.Y., ""Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease"", Proc. Nat. Acad. Sci. U.S.A., 111, 9959-9964, (2014) Silva, D., Weiss. D., Pardo-Avila, F., Da, L., Levitt, M., Wang, D., Huang, X., ""Millisecond Dynamics of RNA Polymerase II Translocation at Atomic Resolution"", Proc. Nat. Acad. Sci. U.S.A., 111, 7665-7670, (2014) Zhang, L., Silva, D.A., Yue, A., Zhang, H., Yan, Y., Huang, X., ""Dynamic Protein Conformations Preferentially Drive Energy Transfer along Active Chain of the Photosystem-II Reaction Center"", Nature Communications, 5:4170 doi: 10.1038/ncomms5170, (2014) Qiao, Q., Bowman, G.R., Huang, X., “Dynamics of an intrinsically disordered protein reveal metastable conformations that potentially seed aggregation”, J. Am. Chem. Soc., 135 (43), 16092–16101, (2013) Pardo-Avila, F., Da, L., Wang, Y., Huang, X., “Theoretical Investigations on Elucidating Fundamental Mechanisms of Catalysis and Dynamics Involved in Transcription by RNA Polymerase”, J. Theor. Comput. Chem., 12(8), 1341005, (2013) (Invited Review) Bowman, G.R., Meng, L., Huang, X., “Quantitative comparison of alternative methods for coarse-graining biological networks ”, J. Chem. Phys., 139, 121905, (2013) Yao, Y., Cui, R.Z., Bowman, G.R., Silva, D.A., Sun, J., Huang, X., “Hierarchical Nystrom Methods for Constructing Markov State Models for Conformational Dynamics ”, J. Chem. Phys., 138, 174106, (2013) Da, L., Pardo-Avila, F., Wang, D., Huang, X., “A Two-State Model for the Dynamics of the Pyrophosphate Ion Release in Bacterial RNA Polymerase”, PLoS. Comp. Bio., 9(4): e1003020, (2013) Zhao, Y., Sheong, F.K., Sun, J., Sander, P., Huang, X.“A Fast Parallel Clustering Algorithm for Molecular Simulation Trajectories”, J. Comput. Chem., 34(2), 95-104, (2013)"