研究领域

Bioanalytical Chemistry Bioinorganic Chemistry Bioorganic Chemistry Biophysical Chemistry Energy Science Environmental Chemistry Inorganic Chemistry Materials Chemistry Nano Chemistry Optics and Imaging Organometallic Chemistry Physical Chemistry Sensor Science Surface Chemistry Sustainable Chemistry

Prof. Banaszak Holl has been a member of the Chemistry Department at the University of Michigan since 1995. The research program is focused in the areas of biological materials, nanotechnology for drug and gene delivery, and organometallic chemistry. A diverse and dynamic group of graduate students and post-doctoral fellows come from a wide variety of backgrounds including graduate programs in Applied Physics, Biomedical Engineering, Biophysics, Chemical Engineering, Chemistry, Macromolecular Science and Engineering, Physics, and the Program in Biomedical Sciences. Given the interdisciplinary nature of the research projects, the differing perspectives of the various scientific and engineering disciplines are critical to our approach to discovery and innovation. The Banaszak Holl group is a founding member of the Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS). We share interdisciplinary, collaborative research space in the Chemistry Department, Medical School, and Physics Department and work in teams on projects in translational Nanomedicine. Weekly research meetings include all members of our teams from the newest undergraduate to the physician who has just finished seeing patients. In collaboration with Prof. Orr of Physics, we run the MNIMBS Scanning Probe Microscopy Lab. Current projects included dendrimer-based targeted drug and imaging agent delivery, the mechanisms of multivalency in biology, the mechanism of gene delivery and expression, and studying the nanoscale structure of Type I collagen.

近期论文

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Fluorophore:Dendrimer Ratio Impacts Cellular Uptake and Intracellular Fluorescence Lifetime. C. A. Dougherty, S. Vaidyanathan, B. G. Orr, M. M. Banaszak Holl. Bioconjugate Chemistry 2015, 26, 304-315. The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells. W.W. Shen, M. A. van Dongen, Y.C. Han, M. M. Yu, Y. Z. Li, G. Liu, M. M. Banaszak Holl, R. Qi. European Journal of Pharmaceutics and Biopharmaceutics 2014, 88, 658-663. Poly(amidoamine) Dendrimer-Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein. M. A. van Dongen, R. Rattan, J. Silpe, C. Dougherty, N. L. Michmerhuizen, M. Van Winkle, B. Huang, S.-K. Choi, K. Sinniah, B.G. Orr, M. M. Banaszak Holl. Molecular Pharmaceutics 2014, 11, 4049-4058. Hyperspectral imaging and characterization of live cells by broadband coherent anti-Stokes Raman scattering (CARS) microscopy with singular value decomposition (SVD) analysis.. A. Khmaladze, J. Jasensky, E. Price, C. Zhang, A. Boughton, X. Han, E. Seeley, X. Liu, M. M. Banaszak Holl, Z. Chen. Applied Spectroscopy 2014, 68, 1116-1122. Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation. M. A. van Dongen, C. A. Dougherty, M. M. Banaszak Holl. Biomacromolecules 2014, 15, 3215-3234. Diffusion NMR Study of Generation-Five PAMAM Dendrimer Materials. M. A. van Dongen, B. G. Orr, and M. M. Banaszak Holl. Journal of Physical Chemistry B 2014, 118, 7195-7202. Quantification of cytosolic plasmid DNA degradation using high-throughput sequencing: implications for gene delivery. R. Rattan, A.U. Bielinska, M. M. Banaszak Holl. Journal of Gene Medicine 2014, 16, 75-83. Avidity Mechanism of Dendrimer-Folic Acid Conjugates. MA van Dongen, JE Silpe, CA Dougherty, AK Kanduluru, SK Choi, BG, Orr, PS Low, MM Banaszak Holl. Molecular Pharmaceutics 2014, 11, 1696-1706. Isolation and Characterization of Precise Dye/Dendrimer Ratios. C. A. Dougherty, J. C. Furgal, M. A. van Dongen, T. Goodson, M. M. Banaszak Holl, J. Manono, S. DiMaggio. Chemistry a European Journal 2014, 20, 4638-4645. Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell Patch Clamp. S. Vaidyanathan, B. G. Orr. M. M. Banaszak Holl. Journal of Physical Chemistry B 2014, 118, 2112-2123. Aryl Halide Radical Clocks as Probes of Stannylene/Aryl Halide C-H Activation Rates. A. Kavara, M. M. Kheir, J. W. Kampf, M. M. Banaszak Holl. Journal of Inorganic and Organometallic Polymers and Materials 2014, 24, 250-257. Avidity Modulation of Folated-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles. J. E. Silpe, M. Sumit, T. P. Thomas, B. Huang, A. Kotlyar, M. A. van Dongen, M. M. Banaszak Holl, B. G. Orr, S. K. Choi. ACS Chemical Biology 2013, 8, 2063-2071. PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures. M. A. van Dongen, S. Vaidyanathan, M. M. Banaszak Holl. Soft Matter 2013, 9, 11188-11196. Epithelial-Mesenchymal Transition Enhances Nanoscale Actin Filament Dynamics of Ovarian Cancer Cells. S. Lee, Y. Yang, D. Fishman, M. M. Banaszak Holl, S. Hong. Journal of Physical Chemistry B 2013, 117, 9233-9240. Crystallinity and compositional changes in carbonated apatites: Evidence from 31P solid-state NMR, Raman, and AFM analysis.. J.-D. P. McElderry, P. Zhu, K. H. Mroue, J. Xu, B. Pavan, M. Fang, G. Zhao, E. McNerny, D. H. Kohn, R. T. Franceschi, M. M.Banaszak Holl, M. M. J. Tecklenburg, A. Ramamoorthy, M. D. Morris. Journal of Solid State Chemistry 2013, 206, 192-198. Polyplex-Induced Cytosolic Nuclease Activation Leads to Differential Transgene Expression. R. Rattan, S. Vaidyanathan, G. S.-H. Wu, A. Shakya, B. G. Orr, M. M. Banaszak Holl. Molecular Pharmaceutics 2013, 10, 3013-3022. Variation in type I collagen fibril nanomorphology: the significance and origin. M. Fang, M. M. Banaszak Holl. BoneKEy 2013, 2, 394. Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer. M. A. van Dongen, A. Desai, B. G. Orr, J. R. Baker, M. M. Banaszak Holl. Polymer 2013, 54, 4126-4133. Polyplex Exposure Inhibits Cell Cycle, Increases Inflammatory Response, and Can Cause Protein Expression without Cell Division. R. L. Matz, B Erickson, S. Vaidyanathan, J. F. Kukowska-Latallo, J. R. Baker, B. G. Orr, and M. M. Banaszak Holl. Molecular Pharmaceutics 2013, 10, 1306-1317. Attractive Hydration Forces in DNA-Dendrimer Interactions on the Nanometer Scale. M. Mills, B. G. Orr, M. M. Banaszak Holl, I. Andricioaei. Journal of Physical Chemistry B 2013, 117, 973-981.