研究领域

Bio-physical, Bio-analytical and Bio-inorganic chemistry. Chemistry problems derived from life sciences.

Bio-physical, Bio-analytical and Bio-inorganic chemistry Prof. Li’s main interest is in the chemistry problems derived from life sciences. The main research approaches include Bio-physical (linear and nonlinear Raman spectroscopies),Bio-analytical (electrochemical and optical sensing methods)and bio-inorganic(synthesis and characterization of bio-mimetic models for the active sites of metallo-enzymes). An important aspect of our research approach is to fabricate functional nano-structured materials with novel optical and electrochemical properties and to explore their applications in bio-physical and bio-analytical chemistry.

近期论文

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""Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D-aspartate Receptors and Neuronal Nitric Oxide Synthase"" Molecular Pharmacology, 71: 1258-1267 (2007). ""Dendritic Nanostructures of Silver: Facile Synthesis, Structural Characterizations, and Sensing Applications"" Langmuir 22, 4836-4842 (2006). ""Surface-enhanced hyper Raman and Surface-enhanced Raman Scattering from Molecules Adsorbed on Nanoparticles-on-Smooth-Electrode (NOSE) Substrate. Pyridine, Pyrazine and Benzene"" J. Raman Spectrosc. 36: 555-573 (2005). ""Polyelectrolyte Multilayer as Matrix for Electrochemical Deposition of Gold Clusters: Toward Super-Hydrophobic Surface"" J. Am. Chem. Soc., 126: 3064-3065 (2004). ""Converting Cytochrome c into a Peroxidase-Like Metalloenzyme by Molecular Design"" ChemBioChem 8: 607–609文字方塊: 24mm x 27mm ""Synthesis, crystal structure and nuclease activities of copper(II) complexes with asymmetric tridentate ligands"" J. Inorg. Biochem., 98, 423-429 (2004). ""Synthesis and Characterization of Aqua-bridged Dimetallic Complexes, M2(m-H2O)(-OAc)2(Im)4(OAc)2 (M = Mg2+, Mn2+, and Ni2+) – Structural Models for the Active Sites of Dimetallic Hydrolases"" J. Inorg. Biochem. 92(2): 128-136 (2002). ""The Design of New Molecular Light Swithces for DNA"" J. Biol. Inorg. Chem., 6(2), 143-150 (2001).