奚望 - 浙江大学

个人简介

奚望博士2001年毕业于南京大学生物系，获得学士学位；2008年毕业于中科院神经科学研究所，在郭爱克院士指导下研究果蝇的学习记忆与注意、抉择等行为的神经机制，相关工作发表于European Journal of Neuroscience；Science；J. Neurosci. 等国际著名杂志。之后在浙江大学附属医院及医学院进行博士后研究工作，在张宏教授、段树民院士指导下主要开展大鼠的注意行为成像以及小鼠睡眠行为的光遗传学控制及多道电生理记录工作，相关工作发表于J. Nucl. Med. ; Current biology; Nature Neurosci. 等国际知名杂志。2014年加入浙江大学系统神经与认知科学研究所。

研究领域

1.脑的高级认知功能，尤其是注意行为的相关神经机制，探索意识问题的本质。整合行为学、多道电生理以及光遗传学等技术来研究注意行为中的特定神经元的调控编码机制。 2.用目前国际先进的光遗传学技术结合多道电生理技术在转基因小鼠上结合生物工程控制技术研究睡眠调控的神经机制，从而进一步对睡眠的进行操控。

近期论文

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Y. L. Wang, X. Han, W. Xi, J. Y. Li, A. W. Roe, P. Lu, J. Qian, Bright AIE Nanoparticles with F127 Encapsulation for Deep-Tissue Three-Photon Intravital Brain Angiography. Adv. Healthcare Mater. 2017, 1700685. （IF 5.11） Alifu, N; Yan, LL; Zhang, HQ; Zebibula, A; Zhu, ZG; Xi, W; Roe Wang, A; Xu, B*; Tian, WJ and Qian, J*. “Organic dye doped nanoparticles with NIR emission and biocompatibility for ultra-deep in vivo two-photon microscopy under 1040 nm femtosecond excitation”, Dyes Pigments, 143: 76-85, (2017). (IF 3.54) Zhibing Tan, Yu Liu, Wang Xi,Huifang Lou, Liya Zhu, Zhi-fei Guo, Lin Mei, and Shumin Duan. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nature Communications.2017 Jan 27;8:13772 （IF 12.12） Hongbin Yang; Junhua Yang; Wang Xi; Sijia Hao; Benyan Luo; Xiaobin He; Liya Zhu; Huifang Lou; Yanqin Yu; Fuqiang Xu; Shumin Duan; Hao Wang. Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear. Nature Neuroscience 19, 283–289 (2016) （IF 17.84 ） Yalun Wang; Rongrong Hu;Wang Xi; Fuhong Cai; Shaowei Wang; Zhenfeng Zhu; Rongpan Bai; Jun Qian. Red emissive AIE nanodots with high two-photon absorption efficiency at 1040 nm for deep-tissue in vivo imaging. Biomed Opt Express. 2015 Oct 1; 6(10): 3783–3794. （IF 3.34） Jun Qian; Zhenfeng Zhu; Chris Wai Tung Leung; Wang Xi; Liling Su; Guangdi Chen; Anjun Qin; Ben Zhong Tang; Sailing He. Long-term Two-photon Neuroimaging with a Photostable AIE Luminogen. Biomed Opt Express.2015 Apr 1; 6(4): 1477–1486. （IF 3.34） Shaowei Wang; Wang Xi; Fuhong Cai; Xinyuan Zhao; Zhengping Xu; Jun Qian; Sailing He. Three-Photon Luminescence of Gold Nanorods and ItsApplications for High Contrast Tissue and Deep In Vivo Brain Imaging, Theranostics,5(3), pp 251-266, 2015/1/1. （IF 8.71） Chu, Liliang; Wang, Shaowei; Li, Kanghui; Xi, Wang; Zhao, Xinyuan; Qian, Jun. Biocompatible near-infrared fluorescent nanoparticles for macro and microscopic in vivo functional bioimaging, Biomedical Optics Express, 5(11), pp 4076-4088, 2014/11/1. （IF 3.34） Han, Yong; Shi, Yu-feng; Xi, Wang; Zhou, Rui; Tan, Zhi-bing; Wang, Hao; Li, Xiao-ming; Chen, Zhong; Feng, Guoping; Luo, Minmin; Huang, Zhi-li; *Duan, Shumin; Yu, Yan-qin. Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions,Current Biology, 24(6), pp 693-698, 2014/3/17. （IF 8.85）