SADLER, Peter J. - University of Warwick

个人简介

B.A. (1969) M.A., D.Phil. (1972) University of Oxford Royal Society of Chemistry Award for Inorganic Biochemistry (1993) Dwyer Medal, University of New South Wales, Australia (1999) Fellow of the Royal Society of Edinburgh (1999) Fellow of the Royal Society of London (2005) Marlies and Hans Zimmer International Scholar, University of Cincinnati (2006)

研究领域

Chemistry of metals in medicine (bioinorganic chemistry, inorganic chemical biology and medicine). Design and chemical mechanism of action of therapeutic metal complexes, including organometallic arene anticancer complexes, photoactivated metal anticancer complexes (for photochemotherapy), metallomacrocycles as antivirals and stem-cell-mobilising agents, and metalloantibiotics. Besides synthesis of co-ordination complexes, research involves studies of interactions with targets such as RNA, DNA and proteins, and often industrial and international interdisciplinary collaborations.

近期论文

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The Potent Oxidant Anticancer Activity of Organoiridium Catalysts. Z. Liu, I. Romero-Canelón; B. Qamar, J.M.Hearn, A. Habtemariam, N.P.E. Barry, A.M. Pizarro, G.J. Clarkson, P.J. Sadler Angew. Chem., Int. Ed. 2014, DOI: 1010.1002/anie.201311161. De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Y. Zhao, N.J. Farrer, H. Li, J.S. Butler, R.J. McQuitty, A. Habtemariam, F. Wang, P.J. Sadler Angew. Chem. Int. Ed. 2013, 52, 13633-13637. Challenges for Metals in Medicine: How Nanotechnology May Help to Shape the Future N.P.E. Barry, P.J. Sadler ACS Nano 2013, 7, 5654-5659. Next generation metal anticancer complexes: Multi-targeting via redox modulation I. Romero-Canelón, P.J. Sadler Inorg. Chem. 2013, 52, 12276–12291. Cancer chemistry: designing new drugs for cancer treatment. A.M. Pizarro, P.J. Sadler Ch.15 pp 438-460. Biologically targeted agents from bench to besideM. Khan, P.J.Sadler, A.M. Pizarro, S. Pelengaris. Ch.16, pp 461-508 in The Molecular Biology of Cancer. A bridge from bench to bedside. S, Pelengaris and M. Khan eds., 2nd ed. Wiley-Blackwell, 2013 Metal–DNA Coordination Complexes A.M. Pizarro, N.P.E. Barry, P.J. Sadler In: Jan Reedijk and Kenneth Poeppelmeier, editors. Comprehensive Inorganic Chemistry II, Vol 3. Oxford: Elsevier; 2013, p. 751-784. Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes. Z. Liu, R.J. Deeth, J.S. Butler, A. Habtemariam, M.E. Newton, P.J. Sadler Angew. Chem. Int. Ed. 2013, 52, 4194-4197. Tryptophan Switch for a Photoactivated Platinum Anticancer Complex. J.S. Butler, J.A. Woods, N.J Farrer, M.E. Newton, P.J. Sadler J. Am. Chem. Soc. 2012, 134, 16508-16511. Two-photon-activated ligand exchange in platinum(II) complexes. Y. Zhao, G.M. Roberts, S.E. Greenough, N.J. Farrer, M.J. Paterson, W.H. Powell, V.G. Stavros, P.J. Sadler Angew. Chem. Int. Ed. 2012, 51, 11263-11266. Organometallic ruthenium and iridium transfer hydrogenation catalysts using coenzyme NADH as a cofactor. S. Betanzos-Lara, Z. Liu, A.M. Pizarro, B. Qamar, A. Habtemariam, P.J. Sadler Angew. Chem. Int. Ed. 2012, 51, 3897-3900. Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies N.P.E. Barry, P.J. Sadler Chem. Soc. Rev. 2012, 41, 3264–3279 Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex F. Barragán, P. López-Senín, L. Salassa, S. Betanzos-Lara, A. Habtemariam, V. Moreno, P.J. Sadler, V. Marchán J. Am. Chem. Soc. 2011, 133, 14098-14108.