个人简介

B.Sc. (Ohio State University ); Ph.D. (Wayne State University) Professional Experience June 1998 - June 2000: Post-Doctoral Research Associate, The Scripps Research Institute, La Jolla, California July 2000 - September 2001: Research Scientist, Wyeth, Pearl River, New York October 2001 - May 2007: Assistant Professor, The University of Hong Kong, Hong Kong June 2007 - present: Associate Professor, The University of Hong Kong, Hong Kong

研究领域

Organic chemistry

Our research is divided into the following areas: Organocatalysis in Organic Synthesis We are interested in developing new variations of different reactions and improved catalysts for performing them. In particular, much of our research has focused on phosphine mediated reactions. For example, we have developed the first example of a catalytic Mitsunobu reaction and investigated other reactions such as the Morita-Baylis-Hillman reaction, alkyne isomerization processes, the Wittig reaction, etc. Currently we are working to further optimize such processes and to develop new efficient tandem or cascade systems. Putting waste to work: Lu. J.; Toy, P. H. Chem. Asian J. 2011, 6, 2251-2254. Natural Products Synthesis The amide hydroxy-α-sanshool is responsible for the mild numbing sensation experienced when Sichuan (or Szechuan) peppercorns (huajiao) are eaten. It has been synthesized in six steps from simple commercially available starting materials using Wittig reactions as the key transformations for construction of the carbon skeleton. The penultimate synthetic intermediate was 2E,6Z,8E,10E-dodecatetraenoic acid, and its crystalline nature allowed it, and thus hydroxy-α-sanshool, to be purified to a very high level of stereochemical homogeneity. Wu, B.; Li, K.; Toy, P. H. Synlett 2012, 25624-2566. This research was highlighted in many Hong Kong newspapers (Apple Daily, Headline Daily, Hong Kong Economic Times, Oriental Daily, Sing Tao, South China Morning Post, Wei Po, etc.), on major Chinese language website (sina.com, etc.), distributed by the China News Agency, and reported by the Asia Television Network. Polymer-Supported Catalysts, Reagents and Ligands Another area we have been intensively exploring is the development of polymeric ligands, reagents and catalysts and their use in organic syntheses. A broad array of soluble and insoluble polymers functionalized with amine, arsine, nitroxyl radical, phosphine, sulfide, sulfoxide and thiourea have been successfully synthesized and used in diverse applications. Simplified product purification and easy recovery and reuse of supported catalyst were allowed for these synthetic systems. Our current interests are focused on the development of rasta resin type polymers, bifunctional polymeric catalysts and other novel functional solid materials.

近期论文

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Yang, Y.-C.; Leung, D. Y. C.; Toy, P. H. Rasta Resin-TBD as a Reusable Catalyst for Transesterification Reactions. Synlett 2013, 1870-1874. Lu, J.; Toy, P. H. Multifunctional Organic Polymeric Catalysts and Reagents. Pure Appl. Chem. 2013, 85, 543-556. Wu, B.; Li, K.; Toy, P. H. Synthesis of Hydroxy-α-Sanshool. Synlett 2012, 2564-2566. Diebold, C.; Lu, J.; Becht, J.-M.; Toy, P. H.; Le Drian, C. An Efficient and Reusable Palladium Catalyst Supported on a Rasta Resin for Suzuki-Miyaura Cross-Couplings. Eur. J. Org. Chem. 2012, 893-896. Teng, Y.; Lu, J.; Toy, P. H. Rasta Resin-PPh3-NBniPr2 and its Use in One-Pot Wittig Reaction Cascades. Chem. Asian J. 2012, 7, 351-359. Lu, J.; Toy, P. H. Reactions of Nitroalkenes with Sulfur Ylides or Nitroalkanes Catalyzed by Amine-Thiourea Bifunctional Polymeric Organocatalysts. Synlett 2011, 3085-3090. Hermeke, J.; Toy, P. H. Phosphonium Ion Tagged Chiral Phosphoric Acids and Their Application in Friedel-Crafts Reactions of Indoles. Tetrahedron 2011, 67, 4103-4109. Lu, J.; Toy, P. H. Tandem One-Pot Wittig/Reductive Aldol Condensation Reactions in which the Waste from One Process Catalyzes a Subsequent Reaction. Chem. Asian J. 2011, 6, 2251-2254. Lu, J.; Toy, P. H. Organocatalytic Decarboxylative Doebner-Knoevenagel Reactions Between Arylaldehydes and Mono-Ethyl Malonate Mediated by a Bifunctional Polymeric Catalyst. Synlett 2011, 1723-1726. Fu, M. Y.; Guo, J.; Toy, P. H. Synthesis of Dienol Ethers Using the Phosphine-Catalyzed Alkyne Isomerization Reaction. Synlett 2011, 989-991. Lu, J.; Toy, P. H. Rasta Resin-DMAP and its Use as a Recyclable Catalyst for the Addition of Carbon Dioxide to Epoxides. Synlett 2011, 659-662. Teng, Y.; Toy, P. H. Rasta Resin-PPh3BnCl and its Use in Chromatography-Free Carbonyl Cyanosilylation Reactions. Synlett 2011, 551-554. Leung, P. S.-W.; Teng, Y.; Toy, P. H. Chromatography-Free Wittig Reactions Using a Bifunctional Polymeric Reagent. Org. Lett. 2010, 12, 4996-4999. Kwong, C. K.-W.; Fu, M. Y.; Law, H. C.-H.; Toy, P. H. Isomerization of Electron-Poor Alkynes to the Corresponding (E,E)-1,3-Dienes Using a Bifunctional Polymeric Catalyst Bearing Triphenylphosphine and Phenol Groups. Synlett 2010, 2617-2620. Leung, P. S.-W.; Teng, Y.; Toy, P. H. Rasta Resin-PPh3 and its Use in Chromatography-Free Wittig Reactions. Synlett 2010, 1997-2001. But, T. Y. S.; Lu, J.; Toy, P. H. Organocatalytic Mitsunobu Reactions Using 3,5-Dinitrobenzoic Acid. Synlett 2010, 1115-1117. Cividino, P.; Dheu-Andries, M.-L.; Ou, J.; Milet, A. ; Py, S.; Toy, P. H. Mechanistic Investigations of the Tributylphospine-Mediated Nitrone Reduction Reaction and Its Application in Cyclic Imine Synthesis. Tetrahedron Lett. 2009, 50, 7038-7042. Lu, J.; Toy, P. H. Organic Polymer Supports for Synthesis and for Reagent and Catalyst Immobilization. Chem. Rev. 2009, 109, 815-838. [PDF] Lam, Y.-L.; Yang, D.; Chan, C.-Y.; Chan, K.-Y.; Toy, P. H. Use of Water-Compatible Polystyrene-Polyglycidol Resin for the Separation and Recovery of Dissolved Precious Metal Salts. Ind. Chem. Eng. Res. 2009, 48, 4975-4979. [PDF] Kwong, C. K.-W.; Fu, M. Y.; Lam, C. S.-L.; Toy, P. H. The Phosphine-Catalyzed Alkyne to 1,3-Diene Isomerization Reaction. Synthesis 2008, 2307-2317. [PDF]