个人简介

B.Sc.(Huabei), M.Sc. CAS(wuhan), Ph.D. 1996(London) HKU Outstanding Young Researcher Award (2004-2005) Outstanding Young Scholar Award, NSFC (2005) HKU Outstanding Researcher Award (2009-2010) Croucher Senior Research Fellow (2010-2011) Member of Editorial Board, Metallomics (RSC), Journal of Inorganic Biochemistry (Elsevier) Series Editor of Metallobiology (RSC)

研究领域

Inorganic chemistry;Chemical biology and biochemistry;Analytical Chemistry

Biological Inorganic Chemistry; Medicinal Chemistry and Inorganic Structural Biology; Metallomics and Metalloproteomics Research interests: Biological Inorganic Chemistry; Metalloproteins; Metallomics and Metalloproteomics 1. Metals in Medicine Medicinal Inorganic chemistry has been stimulating largely by the success of the anticancer drug, cis-platin. Understanding the mechanism of action of these metallodrugs is crucial in order to design more effective drugs. Currently, we focus on the design and synthesis of new metal complexes, their interactions with peptides, proteins and enzymes under a variety of conditions by various chemical and biophysical techniques. 2. Structure and Function of Metal Transport and Storage Proteins A quarter to one-third of proteins are metalloproteins. Metal ions in metalloproteins are critical to the protein's function, structure or stability. In fact, numerous essential biological functions require metal ions. Our current interest lies in a cysteine-rich metalloprotein, neuronal growth inhibitory factor (GIF or metallothionein III) and histidine-rich proteins (e.g. Hpn, HspA). We have solved the three dimensional structure of the a-domain of MT-3, HpHypA and TM4 of DMT1 by NMR, X-ray crystallography and other biophysical techniques. 3. Metallomics and Metalloproteomics Metallomics and metalloproteomics are an emerging field complementary to genomics and proteomics, a frontier of biological inorganic chemistry. We are studying the role, uptake, transport and storage of selected metals essential for protein functions. Targets and binding proteins of metallodrugs will be identified by using a wide variety of state-of-the-art techniques such as proteomics, metallomics and structural biology.

近期论文

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Cheng TF, Li HY, Yang XM, Xia W, Sun H. (2013) Metallomics, 5: 10.1039/C3MT00014A. Hu LG, Cheng TF, He B, Li L, Wang YC, Lai YT, Jiang GB, Sun HZ (2013). """"Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry"""" Angew Chem Int Ed Engl. 52(18):4916-20. doi: 10.1002/anie.201300794. [Pubmed] Hu LG, He B, Wang YC, Jiang GB, Sun HZ (2013). """"Metallomics in environmental and health related research: Current status and perspectives"""" Chinese Science Bulletin 58(2):176. doi: 10.1007/s11434-012-5496-1 Wang XH, Li HY, Du XB, Harris J, Guo ZJ, Sun HZ (2012). """"Activation of carboplatin and nedaplatin by the N-terminus of human copper transporter 1 (hCTR1)"""" Chemical Science 3: 3206-3215. [RSC Publishing] Cheng TF, Li HY, Xia W, Sun HZ (2012). """"Multifaceted SlyD from Helicobacter pylori: implication in NiFe hydrogenase maturation."""" Journal of Biological Inorganic Chemistry 17(3): 331-343. [Pubmed] Du XB, Wang XH, Li HY, Sun HZ (2012). """"Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1)."""" Metallomics 4(7): 679-685. [Pubmed] Li HY, and Sun HZ (2012). """"NMR studies of metalloproteins."""" Topics in Current Chemistry 326: 69-98. [Pubmed] Li HY, and Sun HZ (2012). """"Recent advances in bioinorganic chemistry of bismuth."""" Current Opinion in Chemical Biology 16(1-2): 74-83.[Pubmed] Xia W, Li HY, Yang XM, Wong KB, Sun HZ (2012). """"Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA."""" Journal of Biological Chemistry 287(9): 6753-6763. [Pubmed] Tsang CN, Bianga J, Sun HZ, Szpunar J, Lobinski R (2012). """"Probing of bismuth antiulcer drug targets in H-pylori by laser ablation-inductively coupled plasma mass spectrometry."""" Metallomics 4(3): 277-283. [Pubmed] Tsang CN, Ho KS, Sun H, Chan W (2011). """"Tracking bismuth drug uptake in single Helicobacter pylori cells."""" Journal of the American Chemical Society 133(19): 7355-7357. [Pubmed] Wang XH, Du XB, Li HY, Chan DSB, Sun H (2011). """"The effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activation."""" Angewandte Chemie 50(12): 2706-2711. [Pubmed] Ge RG, Chu IK, Sun HZ (2010). """"Nuclear-based metallomics in metal-based drugs in Advanced nuclear analytical techniques for metallomics and metalloproteomics."""" (Edited by C.Y. Chen, Z.F. Chai, YX Gao), Royal Society of Chemistry, 265-298. [Pubmed] Cun SJ, Sun HZ (2010). """"A zinc binding site by negative selection induces metallodrug susceptibility of an essential chaperonin."""" Proceedings of the National Academy of Sciences 107: 4943-4948. (highlighted in A-IMBN, http://www.natureasia.com/A-IMBN/cms/preview.php?article_id=374) [Pubmed] Sun XS, Tsang CN and Sun HZ (2009). """"Identification of binding proteins of metallodrugs by (metallo)proteomics."""" Metallomics 1: 25-31. (Featured on the cover of the January issue, 2009) [Pubmed] Xia W, Li HY, Sze KH, Sun HZ (2009). """"Structure of a nickel chaperone, HypA from Helicobacter pylori reveals two distinct metal binding sites."""" Journal of the American Chemical Society 131: 10031-10040. [Pubmed] Cun SJ, Li HY, Ge RG, Lin MCM, Sun HZ (2008). """"A histidine- and cysteine-rich metal binding domain at the Cterminus of heat-shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility."""" Journal of Biological Chemistry 283: 15142-15151. [Pubmed] Wang H, Li HY, Cai B, Huang ZX, Sun HZ (2008). """"The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the protein."""" Journal of Biological Inorganic Chemistry 13: 411-419. [Pubmed] Yang N, Tanner JA, Zheng BJ, Watt RM, He ML, Lu LY, Jiang J-Q, Shum K-T, Lin Y-P, Wong KL, Lin MCM, Kung HF, Sun HZ, Huang JD (2007). """"Bismuth complexes inhibit the SARS coronavirus."""" Angewandte Chemie International Edition 46: 6464-6468. [Pubmed] Yang N, Tanner JA, Wang Z, Huang JD, Zheng BJ, Zhu N, Sun HZ (2007). """"Inhibition of SARS coronavirus helicase by bismuth complexes."""" Chemical Communications 4413-4415. [Pubmed]