Shin, Injae - Yonsei University - Department of Chemistry

个人简介

1. 1993 Standwood Johnston Memorial Fellowship (U of Minnesota) 2. 1994 Departmental Fellowship (U of Minnesota) 3. 2007 Chang Sehee Award (Organic Chemistry Division Award of Korean Chemical Society)

研究领域

Research interests are in the area of chemical biology, including functional studies of glycans using chemical tools, especially carbohydrate microarrays. His research group is also involved in the development of small molecules with differentiation-inducing activity and the construction of target-oriented drug delivery systems. Chemical biology, bioorganic chemistry, carbohydrate chemistry, peptide chemistry

近期论文

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Sung-Kyun Ko, Jiyeon Kim, Deuk Chae Na, Sookil Park, Seong-Hyun Park, Ji Young Hyun, Kyung-Hwa Baek, Nam Doo Kim, Nak-Kyoon Kim, Young Nyun Park, Kiwon Song, Injae Shin “A Small Molecule Inhibitor of ATPase Activity of HSP70 Induces Apoptosis and Has Antitumor Activities”, Chem. Biol., 2015, 22, 391-403 Hyungseoph J. Cho, Gun-Hee Kim, Seong-Hyun Park, Ji Young Hyun, Nak-Kyoon Kim and Injae Shin “Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis”, Mol. Biosyst., 2015, in press, doi: 10.1039/c4mb00695j Sung-Kyun Ko, Sung Kuk Kim, Andrew Share, Vincent M. Lynch, Jinhong Park, Wan Namkung, Wim Van Rossom, Nathalie Busschaert, Philip A. Gale, Jonathan L. Sessler & Injae Shin “Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells”, Nat. Chem., 2014, 6, 885-92 Gun-Hee Kim, Debasish Halder, Jinhong Park, Wan Namkung and Injae Shin “Imidazole-Based Small Molecules that Promote Neurogenesis in Pluripotent Cells”, Angew. Chem. Int. Ed., 2014, 53, 9271-9274 Zhiqian Guo, Gun-Hee Kim, Juyoung Yoon, Injae Shin “Synthesis of a highly Zn(2+)-selective cyanine-based probe and its use for tracing endogenous zinc ions in cells and organisms”, Nat. Protoc., 2014, 9,1245–1254. Hye Yeon Lee, Yoon Pyo Choi, Sunkyung Kim, Taejin Yoon, Zhiqian Guo, Songyi Lee, K. M. K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon “Selective homocysteine turn-on fluorescent probes and their bioimaging applications”, Chem. Commun., 2014, 50,6967-6969. Zhiqian Guo, Sookil Park, Juyoung Yoon, Injae Shin “Recent progress in the development of near-infrared fluorescent probes for bioimaging applications”, Chem. Soc. Rev. 2014, 43, 16-29. Minjeong Kim, Sung-Kyun Ko, Hyemi Kim, Injae Shin, Jinsung Tae “Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals”, Chem. Commun. 2013,49, 7959-7961. Ji Young Choi, Gun-Hee Kim, Zhiqian Guo, Hye Yeon Lee, K.M.K. Swamya, Jaeyoung Pai, Seunghoon Shin, Injae Shin, Juyoung Yoon “Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging”, Biosens. Bioelectron. 2013, 15, 438-441. Xizhe Tian, Kyung-Hwa Baek and Injae Shin “Dual-labeled glycoclusters: synthesis and their application in monitoring lectin-mediated endocytosis”, Mol. BioSyst. 2013, 9, 978-986. Xizhe Tian, Kyung-Hwa Baek and Injae Shin “Dual-targeting delivery system for selective cancer cell death and imaging”, Chem. Sci. 2013, 4, 947-956 Sungjin Park, Jeffrey C. Gildersleeve, Ola Blixt and Injae Shin “Carbohydrate microarrays”, Chem. Soc. rev. 2013, 42, 4310-4326. Jaeyoung Pai, Taejin Yoon, Nam Doo Kim, Im-Soon Lee, Jaehoon Yu, Injae Shin “High-Throughput Profiling of Peptide-RNA Interactions Using Peptide Microarrays”, J. Am. Chem. Soc. 2012, 134, 19287–19296 Zhiqian Guo, Gun-Hee Kim, Injae Shin, Juyoung Yoon,“A cyanine-based fluorescent sensor for detecting endogenous zinc ions in live cells and organisms”, Biometerials 2012, 33, 7818–7827. Sung-Kyun Ko, Injae Shin "Cardiosulfa Induces Heart Deformation in Zebrafish through the AhR-Mediated, CYP1A-Independent Pathway", Chembiochem 2012, 13,1483–1489. Xizhe Tian, Jaeyoung Pai, Injae Shin, “Analysis of Density-Dependent Binding of Glycans by Lectins Using Carbohydrate Microarrays”, Chem. Asian J. 2012, 7, 2052–2060. Zhiqian Guo, Injae Shin, Juyoung Yoon, “Recognition and sensing of various species using boronic acid derivatives”, Chem. Commun. 2012, 48, 5956-5967 . Ji Eon Kwon, Sumin Lee, Youngmin You, Kyung-Hwa Baek, Kei Ohkubo, Jaeheung Cho, Shunichi Fukuzumi, Injae Shin, Soo Young Park, and Wonwoo Nam “Fluorescent Zinc Sensor with Minimized Proton-Induced Interferences: Photophysical Mechanism for Fluorescence Turn-On Response and Detection of Endogenous Free Zinc Ions”, Inorg. Chem. 2012, 51, 8760–8774. Yoonkyung Kim, Hye-youn Jung, Yun Hui Choe, Chaewoon Lee, Sung-Kyun Ko, Soonil Koun, Yohan Choi, Bong Hyun Chung, Byoung Chul Park, Tae-Lin Huh, Injae Shin, Eunkyoung Kim, “High-Contrast Reversible Fluorescence Photoswitching of Dye-Crosslinked Dendritic Nanoclusters in Living Vertebrates ”, Angew. Chem. Int. Ed. 2012, 51, 2878-2882. Kyung-Hwa Baek , Jihye Park and Injae Shin “Autophagy-regulating small molecules and their therapeutic applications ”, Chem. Soc. Rev. 2012, 41, 3245-3263 (Invited paper) (2011 BRIC News) Hyungseoph Jason Cho , Heon Yung Gee , Kyung-Hwa Baek , Sung-Kyun Ko , Jong-Moon Park , Hookeun Lee , Nam Doo Kim , Min Goo Lee , and Injae Shin “A small molecule that binds to an ATPase domain of Hsc70 pro-motes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator (CFTR)”, J. Am. Chem. Soc. 2011, 133, 20267-76. Xizhe Tian, Jaeyoung Pai, Kyung-Hwa Baek, Sung-Kyun Ko, Injae Shin “Fluorophore-labeled, Peptide-based Glycoclusters: Synthesis, Binding Properties for Lectins, and Detection of Carbohydrate-Binding Proteins in Cells”, Chem. Asian J. 2011, 6, 2107-2113. (Invited paper) Xiaoqiang Chen, Xizhe Tian, Injae Shin, Juyoung Yoon "Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species”, Chem. Soc. Rev. 2011, 40, 4783-4804. (2011 BRIC NEWS) Sung-Kyun Ko, Xiaoqiang Chen, Juyoung Yoon, Injae Shin “Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes“, Chem. Soc. Rev. 2011, 40, 2120-2130. (2011 BRIC NEWS)